ABSTRACT
Chronic kidney disease (CKD) is an ever-growing global public health problem affecting more than 10% of the general population worldwide. CKD is associated with an increased risk of cardiovascular disease and all-cause mortality, representing a major burden to the healthcare system. Although multiple studies have determined CKD prevalence in different countries, there is still a significant knowledge gap between epidemiological surveys and real data recorded by healthcare providers. Regarding the Portuguese population, most recent studies revealed a CKD prevalence of 20.9%. However, there is an irregular distribution of CKD prevalence in the country. For example, considering the Madeiran population, a non-published review of lab results of nearly 130,000 patients in our database allowed us an estimation of 20%. Thus, to better comprehend CKD prevalence and its characterization in this region, we designed a study comprising previous studies' strengths as well as aiming to overcome their limitations. The principal objective is to calculate global CKD prevalence in Madeira Island and stratify it by stage of CKD, allowing comparison of our results with recent literature on this subject. We intend to contribute with relevant epidemiological data in the characterization of CKD prevalence in Portugal and, simultaneously, have a more active role in CKD prevention and allocation of resources.
ABSTRACT
Adenovirus infection in transplant recipients may present from asymptomatic viremia to multisystemic involvement. Most frequently, it occurs in the first year after a kidney transplant, and it is secondary to the reactivation of latent disease. However, primary infection may occur, and disseminated disease is more common when related to primary infection. Kidney involvement may be confirmed by biopsy, although diagnosis may be presumptive. Reduction of immunosuppression and supportive care are important components of therapy. CASE DESCRIPTION: A 41-year-old female renal-pancreatic recipient 12 years before with chronic renal graft dysfunction and a functional pancreatic graft had a history of cytomegalovirus and polyoma virus infection 2 years after transplantation. She was taking tacrolimus, mycophenolate mofetil, and prednisolone. The patient was admitted after persistent uncharacteristic diarrhea 3 weeks before hospitalization without any relevant epidemiologic context. She was dehydrated, and the lab results showed worsened kidney function and leucocytosis. The viral culture revealed adenovirus. Vigorous hydration was implemented, and the mycophenolate mofetil dose was reduced. The patient was discharged, and renal function returned to previous values. DISCUSSION AND CONCLUSION: Adenovirus infection has a wide clinical presentation, and multisystemic involvement may occur in transplant recipients. Supportive care is paramount. The clinical features and viral culture confirm the diagnosis, although tissue samples and quantitative polymerase chain reaction may be required in more severe cases.
