ABSTRACT
Uterine leiomyomata are common, affecting 70-80% of women between 30 and 50 years of age. Leiomyomata have been reported for a variety of primate species, although prevalence rates and treatments have not been widely reported. The prevalence, diagnosis, and treatment of uterine leiomyomata in the Alamogordo Primate Facility and the Keeling Center for Comparative Medicine and Research were examined. Uterine leiomyomata were diagnosed in 28.4% of chimpanzees with an average age at diagnosis of 30.4 ± 8.0 years. Advanced age (>30 years) was related to an increase in leiomyomata and use of hormonal contraception was related to a decrease in leiomyomata. As the captive chimpanzee population ages, the incidence of leiomyomata among female chimpanzees will likely increase. The introduction of progesterone-based contraception for nonbreeding research and zoological chimpanzees may reduce the development of leiomyomata. Finally, all chimpanzee facilities should institute aggressive screening programs and carefully consider treatment plans.
Subject(s)
Leiomyoma/veterinary , Pan troglodytes , Primate Diseases/diagnosis , Primate Diseases/epidemiology , Uterine Neoplasms/veterinary , Age Factors , Animals , Contraception/veterinary , Female , Leiomyoma/diagnosis , Leiomyoma/epidemiology , Leiomyoma/therapy , New Mexico/epidemiology , Prevalence , Primate Diseases/therapy , Progesterone/therapeutic use , Texas/epidemiology , Uterine Neoplasms/diagnosis , Uterine Neoplasms/epidemiology , Uterine Neoplasms/therapyABSTRACT
We report here the first documented case of ocular coccidioidomycosis in a chimpanzee (Pan troglodytes). In 1996, a 12-year-old female chimpanzee was undergoing treatment with an experimental triazole, BayR3783, for coccidioidomycosis when she was diagnosed with severe conjunctivitis in the right eye. Subsequent development of a coccidioidal granuloma of the ventral conjunctiva and anterior uvea was noted over the next several months, distorting the lens, iris, pupil, and sclera and progressing to uveitis. Treatment with BayR3783 and subconjunctival injections of triamcinolone were successful in reducing the ocular mass, but extensive damage was done to the lens and cornea. This case study provides an interesting comparison to ocular coccidioidomycosis cases observed in both humans and canines.
Subject(s)
Coccidioidomycosis/diagnosis , Coccidioidomycosis/therapy , Eye/microbiology , Uveitis/diagnosis , Uveitis/therapy , Animals , Coccidioides/metabolism , Coccidioidomycosis/microbiology , Coccidioidomycosis/veterinary , Conjunctivitis/diagnosis , Conjunctivitis/microbiology , Conjunctivitis/therapy , Conjunctivitis/veterinary , Female , Ketoconazole/therapeutic use , Models, Anatomic , Pan troglodytes , Uveitis/microbiology , Uveitis/veterinaryABSTRACT
Of the living apes, the chimpanzee (Pan troglodytes) and bonobo (Pan paniscus) are often presented as possible models for the evolution of hominid bipedalism. Bipedality in matched pairs of captive bonobos and chimpanzees was analyzed to test hypotheses for the evolution of bipedalism, derived from a direct referential model. There was no overall species difference in rates of bipedal positional behavior, either postural or locomotory. The hominoid species differed in the function or use of bipedality, with bonobos showing more bipedality for carrying and vigilance, and chimpanzees showing more bipedality for display.
