Pemetrexed-induced eyelid edema in lung cancer.

Pemetrexed is a novel, multitargeted antifolate approved for the treatment of malignant pleural mesothelioma and non-small cell lung cancer. Although pemetrexed is a safe drug, some adverse effects such as myelosupression and cutaneous reactions are observed. Pemetrexed-induced eyelid edema is a rare side effect of pemetrexed treatment, and until this moment few cases were reported in the medical literature. We reported a new case of pemetrexed-induced eyelid edema in a patient with adenocarcinoma of the lung with brain metastases.

Metabolic syndrome in patients with prostate cancer.

CONTEXT AND OBJECTIVE: Prostate cancer (PCa) is the second most common cancer among men in Brazil. Recently, several studies have hypothesized a relationship between PCa and metabolic syndrome (MS). The aim here was to identify an association between MS and PCa. DESIGN AND SETTING: Cross-sectional study, Fundação de Beneficência Hospital de Cirurgia (FBHC) and Universidade Federal de Sergipe. METHODS: Laboratory and anthropometric parameters were compared between PCa patients (n = 16) and controls (n = 16). RESULTS: The PCa patients showed significantly greater frequency of MS than did the controls (p = 0.034). Serum glucose was higher and high-density lipoprotein-cholesterol was lower than in the controls, although without significant differences. There were significant differences in blood pressure (p = 0.029) and waist-to-hip ratio (p = 0.004). Pearson linear correlation showed a positive association between waist-to-hip ratio and prostate specific antigen (r = 0.584 and p = 0.028). Comparing subgroups with and without MS among the PCa patients, significant differences (p < 0.05) in weight, height, body mass index, hip circumference and lean body mass were observed, thus showing higher central obesity in those with MS. The serum glucose values were also higher in MS patients (p = 0.006), thus demonstrating that insulin resistance has a role in MS physiopathology. CONCLUSIONS: Our study suggests that MS may exert an influence on the development of PCa. However, it would be necessary to expand the investigation field with larger sample sizes and cohorts studied, to test the hypothesis generated in this study.

Metabolic syndrome in patients with prostate cancer / Síndrome metabólica em pacientes com câncer de próstata

CONTEXT AND OBJECTIVE: Prostate cancer (PCa) is the second most common cancer among men in Brazil. Recently, several studies have hypothesized a relationship between PCa and metabolic syndrome (MS). The aim here was to identify an association between MS and PCa. DESIGN AND SETTING: Cross-sectional study, Fundação de Beneficência Hospital de Cirurgia (FBHC) and Universidade Federal de Sergipe. METHODS: Laboratory and anthropometric parameters were compared between PCa patients (n = 16) and controls (n = 16). RESULTS: The PCa patients showed significantly greater frequency of MS than did the controls (p = 0.034). Serum glucose was higher and high-density lipoprotein-cholesterol was lower than in the controls, although without significant differences. There were significant differences in blood pressure (p = 0.029) and waist-to-hip ratio (p = 0.004). Pearson linear correlation showed a positive association between waist-to-hip ratio and prostate specific antigen (r = 0.584 and p = 0.028). Comparing subgroups with and without MS among the PCa patients, significant differences (p < 0.05) in weight, height, body mass index, hip circumference and lean body mass were observed, thus showing higher central obesity in those with MS. The serum glucose values were also higher in MS patients (p = 0.006), thus demonstrating that insulin resistance has a role in MS physiopathology. CONCLUSIONS: Our study suggests that MS may exert an influence on the development of PCa. However, it would be necessary to expand the investigation field with larger sample sizes and cohorts studied, to test the hypothesis generated in this study.

CONTEXTO E OBJETIVO: O câncer de próstata (CaP) é o segundo câncer mais comum entre os homens no Brasil. Recentemente diversos estudos têm apresentado a hipótese de que o CaP possa estar relacionado à síndrome metabólica (SM). O objetivo é identificar associação entre SM e CaP. TIPO DE ESTUDO E LOCAL: Estudo transversal analítico. Fundação de Beneficência Hospital de Cirurgia (FBHC) e Universidade Federal de Sergipe. MÉTODOS: Foram comparados parâmetros laboratoriais e antropométricos entre um grupo com CaP (n = 16) e um grupo controle (n = 16). RESULTADOS: O grupo com CaP apresentou ocorrência significativamente maior de SM em relação ao grupo controle (p = 0,034). A glicemia foi superior e a lipoproteína de alta densidade-colesterol (HDL-c) inferior quando comparados ao controle, contudo sem diferença significativa. Foi observada diferença significativa quanto à pressão arterial (p = 0,029) e à relação cintura/quadril (p = 0,004). A correlação linear de Pearson revelou associação positiva significativa entre o valor da relação cintura/quadril e o nível de antígeno prostático específico (r = 0,584 e p = 0,028). Comparando-se os subgrupos com SM e sem SM dentro do grupo com CaP, houve diferenças significativas (p < 0,05) quanto a peso, altura, índice de massa corporal, circunferência do quadril e massa magra, evidenciando o maior grau de obesidade do tipo central nos indivíduos com SM. Os níveis glicêmicos foram também significativamente maiores naqueles com SM (p = 0,006), demonstrando o papel da resistência insulínica na fisiopatologia da SM. CONCLUSÕES: Nosso estudo sugere que a SM exerce influência sobre o desenvolvimento do CaP, contudo é necessário ampliar o campo de investigação, com estudos com maior número de indivíduos, e avaliando também os hábitos e estilo de vida.