Immunoexpression of á2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities

Objective: The purpose of the present study was to investigate the expression of the α2-integrin subunit and heat shock protein 47 (Hsp47) in two families with isolated gingival fibromatosis (GF) form and one family with GF associated with dental abnormalities and normal gingiva (NG). Study Design: Immunohistochemistry was performed with antibodies against α2-integrin and Hsp47 in specimens from two unrelated families with hereditary gingival fibromatosis (Families 1 and 2) and from one family with a gingival fibromatosis-associated dental abnormality (Family 3); NG samples were used for comparison. The results were analysed statistically. Results: Immunoreactivity for α2-integrin and Hsp47 was observed in the nucleus of epithelial cells of both the basal and suprabasal layer and a more discreet signal was noted in connective tissue in all study samples. Hsp47 showed higher immunoreactivity in Family 2 compared with the other families (p≤0.05). Despite the markup α2-integrin was higher in Family 3 there was no statistically significant difference between the families studied (p≥0.05). Conclusions: Our results confirmed the heterogeneity of GF, such that similar patterns of expression of the condition may show differences in the expression of proteins such as Hsp47. Although no difference in α2-integrin expression was observed between GF and NG groups, future studies are necessary to determine the exact role of this protein in the various forms of GF and whether it contributes to GF pathogenesis (AU)

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Immunoexpression of α2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities.

OBJECTIVE: The purpose of the present study was to investigate the expression of the α2-integrin subunit and heat shock protein 47 (Hsp47) in two families with isolated gingival fibromatosis (GF) form and one family with GF associated with dental abnormalities and normal gingival (NG). STUDY DESIGN: Immunohistochemistry was performed with antibodies against α2-integrin and Hsp47 in specimens from two unrelated families with hereditary gingival fibromatosis (Families 1 and 2) and from one family with a gingival fibromatosis-associated dental abnormality (Family 3); NG samples were used for comparison. The results were analysed statistically. RESULTS: Immunoreactivity for α2-integrin and Hsp47 was observed in the nucleus of epithelial cells of both the basal and suprabasal layer and a more discreet signal was noted in connective tissue in all study samples. Hsp47 showed higher immunoreactivity in Family 2 compared with the other families (p ≤ 0.05). Despite the markup α2-integrin was higher in Family 3 there was no statistically significant difference between the families studied (p ≥ 0.05). CONCLUSIONS: Our results confirmed the heterogeneity of GF, such that similar patterns of expression of the condition may show differences in the expression of proteins such as Hsp47. Although no difference in α2-integrin expression was observed between GF and NG groups, future studies are necessary to determine the exact role of this protein in the various forms of GF and whether it contributes to GF pathogenesis.

Profile and scientific production of Brazilian researchers in dental materials

Aim: To describe the demographic characteristics and academic production of the NationalCouncil for the Development of Science and Technology (CNPq) researchers whose areas ofexpertise focus on dental materials. Methods: Secondary data were obtained from the detailsof dentistry researchers registered as receiving a CNPq grant for scientific productivity. Variablessuch as gender, category of scientific productivity grant, time of completion of PhD program,geographical distribution and affiliated institution, scientific production and human resources trainingwere analyzed. Data from 2007-2009 triennium were considered. Mann-Whitney and chisquaretests compared the variables. Results: Researchers in categories 1A + 1B are thosewho completed their PhD program more than 14 years ago. All (100%) of dental materialresearchers are dentists and affiliated to universities, being approximately 92% of those affiliatedto public institutions. Male gender (62.2%) and category 2 grant (40.5%) are prevalent, and ahigh concentration of CNPq grantees in the southeastern region (75.7%) was observed. Ingeneral, there was a predominance of publications in CAPES Qualis B journals (59.0%), but apredominance of publications by new doctors in CAPES Qualis A2 and B1 journals was found.A higher mean of publications of book chapters (0.97) compared with full publications of books(0.43) per researcher was observed. Annually, researchers supervised more scientific initiationgrants (median = 0.45), followed by doctoral (mean = 0.36) and master students (median =0.30). Conclusions: There is a high concentration of researchers in the southeastern region,predominance of male gender and scholars in grant category 2. Publications are mainly inCAPES Qualis B journals. and researchers in grant categories 1C and 1D and with less timedoctoral produce more publications. The publication of books chapters is larger than entirebooks...

Pesquisa odontológica no estado de Minas Gerais- Brasil: relação entre a a FAPEMIG e a produtividade científica / Dentistry research at state of Minas Gerais- Brasil: relation between FAPEMIG and scientific productivity

A Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) é a única agência de fomento à pesquisa científica, tecnológica e inovação do Estado. Foi criada em 1985 e implantada em 1986, com espírito e relevo de urgência para incorporar à tecnologia aos setores industriais. Em decorrência da escassez de estudos mapeando a produção científica e sua relação com o fomento de projetos pela FAPEMIG, este estudo teve como objetivo estabelecer os produtos científicos em Odontologia gerados a partir do financiamento de projetos científicos e tecnológicos de pesquisa do Edital Universal da FAPEMIG. A partir dos arquivos da FAPEMIG, foram reportadas as características gerais dos projetos aprovados bem como a produtividade científica odontológica oriunda dos Editais Universais entre os anos de 1990 a 2002. No período avaliado, 55 projetos aprovados tiveram 33 pesquisadores distintos como coordenadores, abrangendo 10 diferentes especialidades, sendo 40 projetos (72,7%) oriundos de instituições públicas (federal e estadual). Quanto aos produtos obtidos, os mais comuns foram as publicações em anais de eventos científicos (55,5%), seguidas de publicações completas (18,5%) e orientações de alunos de iniciação científica (15,5%). As publicações completas internacionais foram mais comuns que as nacionais. Conclui-se que diferentes áreas da Odontologia foram contempladas nos Editais Universais, com participação ainda limitada na formação de mestres e doutores vinculados aos projetos de pesquisa financiados e uma busca por publicações em periódicos indexados e de qualidade científica comprovada.

Pesquisa odontológica no estado de Minas Gerais - Brasil: análise retrospectiva de 1986 a 2006 / Dentistry research at Minas Gerais state -Brazil- retrospective evaluation between 1986 to 2006

A Fundação de Amparo à Pesquisa do Estado de Minas Gerais (Fapemig) é a única agência de fomento à pesquisa científica, tecnológica e inovação do Estado. Foi criada em 1985 e implantada em 1986, com espírito e relevo de urgência para se incorporar à tecnologia aos setores industriais. Em decorrência da escassez de estudos mapeando a produção científica e o envolvimento das Faculdades de Odontologia, no estado de Minas Gerais, este estudo teve como objetivo estabelecer o perfil dos projetos de pesquisa em Odontologia nos Editais Universais da Fapemig, entre anos de 1986 a 2006. Dessa forma, foi utilizado coleta de informações a partir dos arquivos do banco de dados dos Editais Universais da fapemig, dos últimos vinte e um anos...