ABSTRACT
We studied the efficacy and safety of cefetamet pivoxil (CAT), an oral aminothiazolyl cephalosporin, in a series of open, comparative multicenter studies in 207 women (four study centers) with uncomplicated gonorrhea, and summarized and pooled the results with those of earlier open dose-finding trials (360 men; six study centers). We compared single-dose treatment regimen of CAT--over the range of 400-1500 mg--with spectinomycin, thiamphenicol, ampicillin, or amoxicillin plus probenecid. The overall cure rates were 100% in 88 women treated with 1500 mg CAT and in 137 men treated with 1200 or 1500 mg CAT, 98% (114 of 116 men) in those treated with 800 or 1000 mg CAT, and 93% (42 of 45 men) in those treated with 400 or 500 mg CAT; the composite cure rate of the comparators was 97%. The tolerability of CAT (n = 428) compared favorably (1.8% adverse events) with that of the standard drugs (n = 139) (4.3% adverse events). Single-dose treatment with 1500 mg CAT is effective and safe in adults with uncomplicated gonorrhea.
Subject(s)
Ceftizoxime/analogs & derivatives , Gonorrhea/drug therapy , Adolescent , Adult , Aged , Ceftizoxime/adverse effects , Ceftizoxime/therapeutic use , Female , Humans , Male , Middle Aged , Prospective StudiesABSTRACT
Os autores apresentam um estudo inicial "in vivo" e "in vitro" sobre a contaminacao do conteudo liquido do balao do cateter de Foley. A partir da observacao de que se encontrava turvo o liquido do balao foi realizada uma serie de culturas bacterianas comparativas do liquido do balao, estagnado no canal de irrigacao do cateter de tres vias e da urina de bexiga, concluindo que havia passagem de bacterias atraves dos poros do balao. Propoem o uso de substancias antissepticas no liquido de enchimento do balao a fim de evitar o aparecimento de um foco de infeccao
