[A new contrast medium emulsion for lymphography (author's transl)]. / Neue Kontrastmittelemulsion für die Lymphographie.

A new contrast medium for lymphography has been developed. It is suitable for direct, such as bi-pedal, lymphangiography, and has certain advantages compared with the commercially available contrast medium Ethiodol, such as absence of a lipogranulomatous reaction and less extensive oil emboli in the lungs. It is also possible to use the substance for indirect, retrosternal lymphography. The substance is indirect, retrosternal lymphography. The substance is an emulsion of triglycerides of iodinated poppy seed oil. The method of preparation of the emulsion is described.

[On the effect of iodine containing opaque media on erythrocyte acetylcholinesterase (author's transl)]. / Zur Wirkung von jodhaltigen Kontrastmitteln auf die Erythrozyten-Acetylcholinesterase.

Clinical symptoms of side effects by iodinated opaque media are approximately similar to those caused by inhibition of acetylcholinesterase. The inhibition of acetylcholinesterase of human erythrocytes was tested with the following opaque media in vivo and in vitro: adipiodonmeglumine, meglumine-iothalamate and sodium-iothalamate. Apparently there is no connection between opaque media induced incompatibility and the inhibition of acetylcholinesterase because 1. by the time maximal inhibition is reached most of the renally excreted opaque media has been eliminated, and because 2. a fairly rapid reversibility of the inhibition follows. For patients with congenital variants of acetylcholinesterase it could be of clinical consequence under succinyldicholinanaesthesia.

[Indirect lymphography of the retrosternal lymphatics and of the thoracic duct (author's transl)]. / Indirekte Lymphographie der retrosternalen Lymphbahnen und des Ductus thoracicus

Successful demonstration of the retrosternal lymphatics and of the thoracic duct after infradiaphragmatic injection is reported, using a contrast medium developed by the author. The lymphatics opacify after 45 minutes. After fourteen days the substance can no longer be seen radiogically. Following some preliminary investigations, it is proposed to try the method in humans. The importance of the lymphatic pathways in medial carcinomas of the breast and in the movement of carcinoma cells from the peritoneal cavity and the liver is stressed.

[The effect of tri-iodinated contrast media on acetylcholinesterase of human erythrocytes (author's transl)]. / Die Wirkung trijodierter Röntgenkontrastmittel auf die Erythrozyten-Acetylcholinesterase des Menschen

The side effects of water soluble iodinated contrast media often mimic the clinical picture of acetylcholine intoxication. This prompted us to determine the amount of inhibition of human acetylcholinesterase by the following contrast media in vivo and in vitro: methyl glucamineiodipamide (Biligrafin forte), methylglucamine iothalamate (Conray 60), sodium-iothalamate (Conray 80). In vivo no correlation could be found between clinically manifest adverse reaction and enzyme inhibition after contrast media application. The in vitro values for 50% inhibition of erythrocyte acetylcholinesterase are: methylglucamine-iodipamide: 0.036 M, methylglucamine-iothalamate: 0.158 M, sodium-iothalamate: 0.3 M. Since in vitro, the maximal inhibitory effect of a given dose of contrast media can only be registered after a time interval when most of the contrast media in vivo has already been excreted by the kidneys or extracted by the liver, it seems very improbable that the enzyme inhibition seen in vitro should have any consequence whatsoever under clinical conditions. The in vitro inhibition of acetylcholinesterase is quickly reversible, with nearly all the activity regained 15 min after the removal of the contrast media.