1.
J Org Chem
; 73(13): 5151-4, 2008 Jul 04.
Article
in English
| MEDLINE
| ID: mdl-18540678
ABSTRACT
A general and efficient route to 2-substituted 1,3-cyclopentadiones 3 has been developed. This operationally simple, two-step procedure is amenable to multigram scale preparations of these useful synthetic intermediates. These compounds are then transformed to previously unknown, higher analogues of the Hajos-Parrish-Eder-Sauer-Wiechert ketone (enone 1, R = Me) following an enantioselective Robinson annulation.