Subject(s)
Cryotherapy/methods , Hematopoietic Stem Cell Transplantation/adverse effects , Melphalan/adverse effects , Multiple Myeloma/complications , Stomatitis/etiology , Transplantation, Autologous/adverse effects , Adult , Aged , Female , Hematopoietic Stem Cell Transplantation/methods , Humans , Male , Middle Aged , Prospective Studies , Stomatitis/pathology , Transplantation, Autologous/methodsABSTRACT
Preformed donor-specific human leukocyte antigen (HLA) antibodies have been associated with allograft dysfunction and failure. However, recipients of HLA-identical kidneys can develop acute humoral rejection, implicating putative pathogenic antibodies that are directed against non-HLA antigens. We investigated the presence of endothelial cell-reactive antibodies in 11 patients who experienced early loss of their transplanted kidneys owing to humoral rejection and 1 loss from renal venal thrombosis. We examined the potential efficacy of intravenous immunoglobulin to block the binding of these antibodies, as previously suggested for anti-HLA antibodies.
Subject(s)
Antibodies/blood , Endothelial Cells/immunology , Graft Rejection/immunology , Histocompatibility Antigens Class I/immunology , Kidney Transplantation/immunology , Brazil , Cell Line , Cytotoxicity Tests, Immunologic , Enzyme-Linked Immunosorbent Assay , Flow Cytometry , Histocompatibility Testing , Humans , Immunity, Humoral , Immunoglobulins, Intravenous/metabolism , Transplantation, Homologous , Treatment OutcomeABSTRACT
Authors analyze the characteristics of the stage pT1 and pT2 colorectal cancer and carry their experience on 68 patients operated. The survival of the colon carcinoma has been of 91% to 2 years and 88% to 5 years, while for the rectum has been of 90% to 2 years and 84% to 5 years. The attitude of the Authors has been to perform radical surgery. Lymph node metastases has been taken like only survival predictive factor while the CEA has diagnostic value of recurrence.
Subject(s)
Colorectal Neoplasms/mortality , Colorectal Neoplasms/pathology , Adult , Aged , Female , Humans , Middle Aged , Neoplasm Staging , PrognosisSubject(s)
Histocompatibility Antigens Class I/immunology , Liver Transplantation/immunology , Postoperative Complications/epidemiology , Adolescent , Adult , Female , Graft Rejection/epidemiology , Graft Rejection/immunology , Histocompatibility Antigens Class I/blood , Humans , Male , Middle Aged , Postoperative Complications/immunology , Sensitivity and SpecificitySubject(s)
Graft Survival , Isoantibodies/blood , Liver Transplantation/immunology , Tissue Donors , Adult , Ethnicity , Female , Graft Rejection/epidemiology , Graft Rejection/immunology , Histocompatibility Testing , Humans , Immunoglobulin G/blood , Immunoglobulin M/blood , Liver Transplantation/mortality , Liver Transplantation/physiology , Male , Retrospective Studies , Survival Rate , Treatment OutcomeSubject(s)
Graft Survival/immunology , Heart Transplantation/immunology , Immunoglobulin G/blood , Isoantibodies/blood , T-Lymphocytes/immunology , Ethnicity , Female , Graft Rejection/epidemiology , Graft Rejection/immunology , Heart Transplantation/mortality , Heart Transplantation/physiology , Histocompatibility Testing , Humans , Male , Monitoring, Immunologic , Retrospective Studies , Survival Analysis , Treatment OutcomeABSTRACT
Uma análise do perfil dos antígenos HLA de classe II numa amostra da populaçäo de Säo Paulo é descrita neste trabalho. Os dados foram obtidos através de técnicas de amplificaçäo gênica utilizando-se iniciadores seqüências-específicos para HLA-DRB (PCR-SSP) ou amplificaçäo gênica seguida de hibridaçäo com oligonucleotídeos específicos (PCR-SSOP) para HLA-DQA e DQB. Foram calculadas as freqüências gênicas e as freqüências haplotípicas DRB-DQB e DQA-DQB e a populaçäo mostrou estar em equilíbrio genético de acordo com a lei de Hardy-Weinberg. Finalmente, comparamos também os dados obtidos com os da populaçäo de Porto Velho, Rondônia, salientando a importância da obtençäo de dados regionais para os controles quando se estuda este complexo sistema genético.
