Priming effect in children with Type 1 Diabetes Mellitus.

Previous studies have evidenced cognitive difficulties across various domains in Type 1 Diabetes Mellitus (T1DM) children, but the implicit memory system has not yet been systematically explored.Taking into account that the interplay between memory and perception may be modulated by the semantic category of the stimuli and their salience, we explored explicit and implicit memory using both object and food stimuli to verify whether for T1DM children there is a feebleness in performing the function of memory as a function of the stimuli used.Eighteen T1DM children and 47 healthy children performed an explicit recognition task in which they were requested to judge whether the presented image had already been shown ("old") or not ("new") and an identification priming task in which they were asked to name new and old pictures presented at nine ascending levels of spatial filtering.Results did not reveal any differences between controls and T1DM children in the explicit memory recognition task, whereas some differences between the two groups were found in the identification priming task. In T1DM children, the priming effect was observed only for food images.The dissociation between implicit and explicit memory observed in children with diabetes seems to be modulated by the category of the stimuli, and these results underscore the relevance of taking into account this variable when exploring cognitive functions.

Automatic and controlled attentional orienting in the elderly: A dual-process view of the positivity effect.

The positivity effect in the elderly consists of an attentional preference for positive information as well as avoidance of negative information. Extant theories predict either that the positivity effect depends on controlled attentional processes (socio-emotional selectivity theory), or on an automatic gating selection mechanism (dynamic integration theory). This study examined the role of automatic and controlled attention in the positivity effect. Two dot-probe tasks (with the duration of the stimuli lasting 100 ms and 500 ms, respectively) were employed to compare the attentional bias of 35 elderly people to that of 35 young adults. The stimuli used were expressive faces displaying neutral, disgusted, fearful, and happy expressions. In comparison to young people, the elderly allocated more attention to happy faces at 100 ms and they tended to avoid fearful faces at 500 ms. The findings are not predicted by either theory taken alone, but support the hypothesis that the positivity effect in the elderly is driven by two different processes: an automatic attention bias toward positive stimuli, and a controlled mechanism that diverts attention away from negative stimuli.

Electrophysiological Activity Prior to Self-initiated Movements is Related to Impulsive Personality Traits.

Electrophysiological and neuroimaging studies suggest that our actions are initiated by unconscious mental processes long before awareness of intention to act. The time window between the awareness of the intention to move and the movement onset, which normally permits to exert a conscious "veto" on the impending action, is modulated by individual differences in trait impulsivity. In particular, trait impulsive people show a delayed awareness of the intention to act, probably exceeding the "point of no return", after which the action can no longer be inhibited. In order to investigate if individual differences in the "veto" interval might be explained by differences in the readiness potential (RP) dynamics, nineteen healthy participants underwent an impulsivity trait assessment using the Barratt Impulsiveness Scale (BIS-11) and performed a task based on Libet's clock paradigm, during EEG recordings of pre-movement neural activity. We observed a positive relationship between impulsive personality trait and motor system excitability during the preparation of self-initiated movements. In particular, the RP showed an earlier negative rising phase and a greater amplitude, with the increasing of BIS-11 scores. Based on present results, we conclude hypothesizing that trait impulsivity might be characterized by less effective preparatory inhibition mechanisms, which have a fundamental role in the control of behavior.

Relationship between impulsivity traits and awareness of motor intention.

Deficient voluntary control of behaviour and impulsivity are key aspects of impulse control disorders. The objective of the present study was to evaluate the relationship between behavioural measures of impulsivity and the awareness of voluntary action. Seventy-four healthy volunteers completed the Barratt Impulsiveness Scale (BIS), a questionnaire used to measure impulsive personality traits, and a go/no-go task. Moreover, all participants performed a behavioural task based on the Libet's clock paradigm in which they were requested to report the time of a self-initiated movement (M-judgement) or the time they first feel their intention to move (W-judgement). A positive relationship between the time in which subjects reported the intention to move (W-judgement) and impulsivity measures emerged. Namely, the higher was the score in the attentional and motor impulsivity subscales of the BIS and the number of inhibitory failure responses in the go/no-go task, the lower was the difference between the W-judgement and the actual movement (i.e. the awareness of intention to move was closer to the voluntary movement execution). In contrast, no relationship emerged with M-judgement. The present findings suggest that impulsivity is related to a delayed awareness of voluntary action. We hypothesize that in impulse control disorders, the short interval between conscious intention and actual movement may interfere with processes underlying the conscious 'veto' of the impending action.

Audio-visual integration effect in lateral occipital cortex during an object recognition task: An interference pilot study.

BACKGROUND: Recent neuroimaging data support the hypothesis of a multisensory interplay at low-level sensory-specific cortex. OBJECTIVE: We used an on-line interference approach by rTMS to investigate the role of the left lateral occipital cortex (LOC) in audio-visual (AV) object recognition process. METHODS: Fifteen healthy volunteers performed a visual identification task of degraded pictures presented alone or simultaneously to coherent or non-coherent sounds. Focal 10-Hz rTMS at an intensity of 100% resting motor threshold was delivered simultaneously to the picture. Two blocks of 60 pictures were randomly displayed in two different experimental conditions: rTMS of the left LOC and over Cz. RESULTS: rTMS of the left LOC produced a worsening of the accuracy compared to rTMS over Cz specifically in the coherent AV condition. CONCLUSION: These data support the view that audio-visual interaction effect may occur at early stage of recognition processing.

" The times they aren't a-changin' " rTMS does not affect basic mechanisms of temporal discrimination: a pilot study with ERPs.

In time processing, the role of different cortical areas is still under investigation. Event-related potentials (ERPs) represent valuable indices of neural timing mechanisms in the millisecond-to-second domain. We used an interference approach by repetitive TMS (rTMS) on ERPs and behavioral performance to investigate the role of different cortical areas in processing basic temporal information. Ten healthy volunteers were requested to decide whether time intervals between two tones (S1-S2, probe interval) were shorter (800ms), equal to, or longer (1200ms) than a previously listened 1000-ms interval (target interval) and press different buttons accordingly. This task was performed at the baseline and immediately after a 15-min-long train of 1-Hz rTMS delivered over the supplementary motor area, right posterior parietal cortex, right superior temporal gyrus, or an occipital control area. Task accuracy, reaction time, and ERPs during (contingent negative variation, CNV) and after the presentation of probe intervals were analyzed. At the baseline, CNV amplitude was modulated by the duration of the probe interval. RTMS had no significant effect on behavioral or ERP measures. These preliminary data suggest that stimulated cortical areas are less crucially involved than other brain regions (e.g. subcortical structures) in the explicit discrimination of auditory time intervals in the range of hundreds of milliseconds.

Fearful expressions enhance recognition memory: electrophysiological evidence.

Facial expressions play a key role in affective and social behavior. However, the temporal dynamics of the brain responses to emotional faces remain still unclear, in particular an open question is at what stage of face processing expressions might influence encoding and recognition memory. To try and answer this question we recorded the event-related potentials (ERPs) elicited in an old/new recognition task. A novel aspect of the present design was that whereas faces were presented during the study phase with either a happy, fearful or neutral expression, they were always neutral during the memory retrieval task. The ERP results showed three main findings: An enhanced early fronto-central positivity for faces encoded as fearful, both during the study and the retrieval phase. During encoding subsequent memory (Dm effect) was influenced by emotion. At retrieval the early components P100 and N170 were modulated by the emotional expression of the face at the encoding phase. Finally, the later ERP components related to recognition memory were modulated by the previously encoded facial expressions. Overall, these results suggest that face recognition is modulated by top-down influences from brain areas associated with emotional memory, enhancing encoding and retrieval in particular for fearful emotional expressions.

When memory meets beauty: Insights from event-related potentials.

Facial attractiveness plays a key role in human social and affective behavior. To study the time course of the neural processing of attractiveness and its influence on recognition memory we investigated the event-related potentials (ERPs) elicited in an old/new recognition task in response to faces with a neutral expression that, at encoding, were rated for their attractiveness. Highly attractive faces elicited a specific early positive-going component on frontal sites; in addition, with respect to less attractive faces, they elicited larger later components related to structural encoding and recognition memory. All in all, our results show that facial attractiveness, independently from facial expression, modulates face processing throughout all stages from encoding to retrieval.

Recognition of category-related visual stimuli in Parkinson's disease: before and after pharmacological treatment.

Visual-sensory dysfunctions and semantic processing impairments are widely reported in Parkinson's disease (PD) research. The present study investigated the category-specific deficit in object recognition as a function of both the semantic category and spatial frequency content of stimuli. In the first experiment, the role of dopamine in object-recognition processing was assessed by comparing PD drug naïve (PD-DN), PD receiving levodopa treatment (PD-LD), and control subjects. Experiment 2 consisted of a retest session for PD drug naïve subjects after a period of pharmacological treatment. All participants completed an identification task which displayed animals and tools at nine levels of filtering. Each object was revealed in a sequence of frames whereby the object was presented at increasingly less-filtered images up to a complete version of the image. Results indicate an impaired identification pattern for PD-DN subjects solely for animal category stimuli. This differential pharmacological therapy effect was also confirmed at retest (experiment 2). Thus, our data suggest that dopaminergic loss has a specific role in category-specific impairment. Two possible hypotheses are discussed that may account for the defective recognition of semantically different objects in PD.

Hippocampal function and visual object processing in temporal lobe epilepsy.

Limbic event-related potentials related to verbal but not to visual recognition memory have been found to be attenuated within the epileptic hippocampus of patients with temporal lobe epilepsy (TLE). To identify hippocampal contributions to visual processing and memory we recorded intracranial ERPs directly from within the epileptic and the non-epileptic hippocampus in 12 patients with unilateral TLE during a visual object decision and naming task. While the non-epileptic hippocampus differentiated reliably between real and nonsense objects, this effect was completely eliminated within the epileptic mesial temporal lobe. This finding suggests that the hippocampus proper contributes to the semantic processing of visual objects and may help to explain visual memory deficits in TLE.

Identification of spatially filtered stimuli as function of the semantic category.

The different weight of spatial frequency content in the identification of visual objects was investigated. Subjects were required to identify spatially filtered pictures of animals, vegetables and nonliving objects, displayed at 9 resolution levels of filtering following a coarse-to-fine order. Results showed that spatial frequency content differentially affected the three categories of stimuli. Data suggested a different involvement of low and high spatial frequency channels in visual processing of objects in relation to the semantic category.

Category effects on the processing of plane-rotated objects.

We examined the effects of plane rotations on the identification of exemplars of three semantic categories. In the first two experiments line drawings belonging to three categories (animals, inanimate objects, and vegetables) were presented at four orientations (0 degree, 60 degrees, 120 degrees, and 180 degrees of clockwise rotation). The response time was found to depend on stimulus category. In particular, whereas rotation effects were shown for animals, no effect at all was found for vegetables and only partial effects were found for inanimate objects. The unclear pattern found for inanimate objects was further examined in experiment 3 where the orientation effects on the identification of two subsets of the inanimate category were studied. The hypothesis of view-observation frequency was confirmed. In experiment 4, line drawings of objects at different orientations were presented in physically degraded versions. The minimum amount of visual information necessary to identify rotated stimuli was found to vary as a function of stimulus category as well. Results are discussed, combining current research on both viewpoint-dependence/independence and neural systems involved in category processing.

Identification of Poppelreuter-like pictures as indexed by blinking.

Blinking was recorded in 28 adult participants during the identification of superimposed pictures (similar to Poppelreuter figures), some of which had been presented individually in an earlier study phase. Participants were required to name the pictures at the end of the identification phase. The percentage of correct identifications was greater for combinations formed by old than new pictures, and decreased as the number of pictures in the combination increased. Attentional demands associated with mental load (number of pictures) affected both the rate of blinks produced during the identification process and the latency of the first blink produced after the stimulus onset. The first blink latency increased as the number of pictures increased, and also depended on material to be identified, with longer latencies associated with novel combinations. We suggest that blinking may be used as an index of memory processes involved in visual identification, even in absence of overt (verbal) responses.

Overt and covert identification of fragmented objects inferred from performance and electrophysiological measures.

The authors investigated visual processing leading to object identification by manipulating the number of fragments and nature of the study. During the study, participants either named or drew objects in Experiment 1 and drew them all in Experiment 2. During the test, participants made an identification judgment at each of 6 different fragmentation levels for studied and new objects. Fewer fragments were needed to identify studied than unstudied objects. Reaction times were faster for studied than unstudied objects both at identification and at the preceding level. Event-related brain potentials (ERPs) to unidentified objects were characterized by a late negativity in contrast to a positivity to identified objects. ERPs to studied but not to new objects contained a smaller and later version of the identification positivity at level just prior to identification, which was not due to differential response confidence. Much covert visual analysis and even object identification may precede overt identification, depending on the nature of prior experience.

The covert interplay between perception and memory: event-related potential evidence.

Neurocognitive models of visual object identification have focussed on processes at the moment of identification, when perceivers can actually name what they see. Less well known is the timecourse of processes preceding and leading to actual identification. To track neuromental processes involved in visual identification, behavioral measures and event-related potentials (ERPs) were recorded in two experiments prior to, during and after the identification of fragmented objects, half of which had been shown in their complete versions in a previous study phase. Each object was revealed in a sequence of frames wherein the object was represented by an increasingly less and less fragmented image up to the complete version. A shift in ERPs, around 300 ms and beyond, from negativity to positivity, marked the transition from non-identification to identification. However, while for new stimuli such a shift appeared abruptly from non-identification to identification, for recently-studied objects a late positive wave emerged in response to unidentified fragments at a level just prior to overt identification. Thus, ERPs reflected covert processes associated with a successful match between the current visual information and episodic recently-stored memory traces, which predicted overt identification.

Identification of fragmented pictures in patients with brain damage.

Identification of fragmented pictures was investigated using line drawings (Snodgrass, Smith, Feenan, & Corwin, 1987) in 236 healthy participants and 43 patients with unilateral lesions of the right or left hemisphere. Perceptual closure (the integration of fragments into a meaningful perceptual whole) depended on the amount of physical visual information, the age of the patient, and the location of the lesion. Patients with right-side lesions showed more impairment than those with left-side lesions, confirming the importance of the right hemisphere in perceptual closure tasks. Right-hemisphere functions involved in perceptual closure, however, were not completely abolished, as performance improved with increasing visual information. The advantages of Snodgrass fragmented pictures as a neuropsychological test are discussed.

Event-related potentials in brain-injured patients with neuropsychological disorders: a review.

Investigations using event-related potentials (ERPs) in brain-injured patients affected by neuropsychological disorders of perception, attention, memory, and language, and other special syndromes such as blind-sight, neglect, prosopagnosia, and apraxia are reviewed. These electrophysiological techniques can be used to assess the integrity of specific brain processes during the performance of cognitive tasks in which behavioral impairments are observed. A special feature of ERP technique is that it reveals ongoing and covert processing which may not be fully assessed by measuring only overt behavioral performance.

Pattern reversal visual evoked potentials in patients with hemineglect syndrome.

To investigate basic visual information processing in patients with hemineglect syndrome, pattern reversal visual evoked potentials (VEPs) were recorded in 21 brain-injured patients (10 with neglect symptoms) and 6 healthy subjects. The stimulus was a checkerboard which varied in check size or temporal frequency, presented to the left or right visual field. VEPs recorded in neglect patients to stimuli presented in the subjectively neglected left visual field were comparable in amplitude to those recorded to stimuli presented in the normal right visual field. For stimuli presented centrally, there was no difference in VEPs between neglect patients and brain-damaged patients without neglect. These results support neuropsychological theories that state that the neglect syndrome is more closely related to deficits at post-sensory levels than to impairments in basic visual processing. Some evidence, however, suggests that the nature of the interaction between the two visual hemi-fields may also be altered in neglect patients.

Hemispheric asymmetry in transient visual evoked potentials induced by the spatial factor of the stimulation.

In order to enhance the effect of spatial frequency on the hemispheric asymmetry of visual evoked potentials (VEP), the response amplitudes to ON-OFF modulated gratings were compared with the responses to pattern reversal stimulation. Sinusoidal gratings of different spatial frequencies were presented to six righthanders. VEPs were recorded from temporal leads on each hemisphere. In the left hemisphere, the amplitude was constant for the two modes of presentation and independent of spatial frequency. In the right hemisphere, the response amplitude was larger to the ONSET stage of ON-OFF stimulation than to reversal and presented the characteristic spatial frequency tuning curve. This asymmetry is assumed to reflect a difference in sensitivity of the two hemispheres to the spatiotemporal characteristics of the stimulus. The relevance of these findings is discussed in relation to the other hemispheric specialization models.

Rhythmic variations of P100 component of pattern-reversal visual evoked potentials.

Pattern-reversal visual evoked potentials (EPs) were recorded in seven adult subjects to assess the existence of rhythmic variations in processing visual information at a primary stage. During a session of two hours, sixty EPs were recorded on the left and right cerebral hemispheres. The amplitude of N75-P100 component was measured. Remarkable variations were found with a periodicity from 15 to 60 min in six out of seven subjects. No hemispheric differences were found in the rhythmic variations. The results are in agreement with the behavioral data which show ultradian variations in visual performance depending on a general activation oscillator.