1.
J Neurophysiol
; 96(2): 524-5, 2006 Aug.
Article
in English
| MEDLINE
| ID: mdl-16835361
Subject(s)
Adrenergic Uptake Inhibitors/pharmacology , Evoked Potentials, Somatosensory/drug effects , Methylphenidate/pharmacology , Norepinephrine/physiology , Somatosensory Cortex/drug effects , Sympathetic Nervous System/physiology , Synaptic Transmission/physiology , Animals , Electrophysiology , Male , Norepinephrine/metabolism , Rats , Rats, Long-Evans , Sympathetic Nervous System/drug effects , Sympathetic Nervous System/metabolism
2.
Science
; 306(5697): 882-4, 2004 Oct 29.
Article
in English
| MEDLINE
| ID: mdl-15514161
ABSTRACT
The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.
