Subject(s)
Electromagnetic Fields/adverse effects , Industry , Noise/adverse effects , Radio Waves , Animals , Brain/metabolism , Citric Acid Cycle/physiology , Electron Transport/physiology , Liver/metabolism , Lymphocytes/metabolism , Male , Membrane Proteins/metabolism , Mitochondria/metabolism , Multienzyme Complexes/metabolism , Rats , Spleen/metabolism , Spleen/ultrastructure , Thymus Gland/metabolism , Thymus Gland/ultrastructureABSTRACT
Interrelations among changes in 11-oxycorticosteroids (11-OSC) in blood plasma, catecholamines (CA), and acetylcholinesterase (AChE) activity in nerve fibres of the thymus, as well as qualitative content and proliferative capacity of thymic and blood cells under the effect of the rat recombinant interleukin-1 beta (IL-1beta) normally and under conditions of hypothalamic-pituitary-adrenocortical depression, were studied. The changes were the most obvious within 15 and 120 min following the IL-2 beta administration: elevation of the 11-OSC, increase in the CA content, and decrease in the AChE activity in thymic nerve fibres. Preliminary administration of dexamethasone prevented the effects.
Subject(s)
Interleukin-1/physiology , Neuroimmunomodulation/physiology , Thymus Gland/immunology , 11-Hydroxycorticosteroids/blood , Acetylcholinesterase/metabolism , Animals , Catecholamines/metabolism , Cell Division/drug effects , Dexamethasone/pharmacology , Hypothalamo-Hypophyseal System/drug effects , Hypothalamo-Hypophyseal System/physiology , Interleukin-1/pharmacology , Male , Nerve Fibers/enzymology , Nerve Fibers/metabolism , Neuroimmunomodulation/drug effects , Pituitary-Adrenal System/drug effects , Pituitary-Adrenal System/physiology , Rats , Recombinant Proteins/pharmacology , T-Lymphocytes/cytology , T-Lymphocytes/drug effects , Thymus Gland/cytology , Thymus Gland/ultrastructureABSTRACT
Hormonal status (blood content of triiodothyronine, thyroxin, insulin, 11-hydroxycorticosteroids), dehydration in the Krebs cycle, and activity of the first enzyme in the pentose-phosphate cycle, glucose-6-phosphate dehydrogenase, in the brain and myocardium of white rats were studied at different time periods after separate and combined prolonged exposure to radiation in relatively small doses and heat. It was found that combination of ionizing radiation and heat led to hypofunction of the endocrine glands and inhibition of dehydration processes in the Krebs Cycle.