[The problems in organizing and conducting radionuclide research at a diagnostic center]. / Problemy organizatsii i provedeniia radionuklidnykh issledovanii v usloviiakh diagnosticheskogo tsentra.

The paper is devoted to analysis of the activities of the laboratory of radionuclide investigations of the Krasnodar Territorial Diagnostic Center over 10 months. Recommendations were issued how to equip and staff such laboratories in diagnostic centers. Requisite conditions for the interaction of these laboratories with other units of diagnostic centers were defined.

[X-ray and radionuclide studies of bones and joints in psoriasis]. / Rentgenologicheskie i radionuklidnye issledovaniia kostei i sustavov pri psoriaze.

Radiography of the bones and joints was performed in 133 psoriatic patients; osteoscintigraphy with 99mTc-phosphate compounds was also performed in 42 of them. On the basis of x-ray findings 3 types of osteoarticular psoriasis were singled out: psoriatic polyarthritis, psoriatic polyarthrosis and psoriatic arthropathy. The most ample information on the type, activity and spreading of a pathological process in the bones and joints in psoriasis can be obtained from the combination of the x-ray and radionuclide methods.

[Dynamic esophageal scintigraphy in assessing the degree of thyroid cancer spread]. / Dinamicheskaia ézofagostsintigrafiia v otsenke stepeni rasprostranennosti raka shchitovidnoi zhelezy.

A total of 17 thyroid cancer patients with various degrees of local tumor spreading were investigated in gamma chambers OH-110 (USA) and MB-9100 (Hungary). Dynamic esophageal scintigraphy was performed in all the patients (with liquid and solid radioactive boluses). Marked esophageal motor dysfunction was revealed in qualitative assessment of scintigrams. Computerized assessment of esophagograms showed early signs of dysphagia.

[2-isotope study in the diagnosis of thyroid cancer]. / Dvukhizotopnoe issledovanie v diagnostike tireoidnogo raka.

Altogether 54 patients with thyroid nodal lesions (40 of them had thyroid carcinoma) were investigated by 75Se-methionine and a thyrotropic RP. 75Se-methionine turned out to be inappropriate for differential diagnosis of benign and malignant thyroid lesions because of many false-negative results. The combination of positive scanning with 75Se-methionine and 99mTc-pertechnetate (or 131I) raised the diagnostic informative value of the method.

[Scintigraphy in the evaluation of postoperative disorders of pulmonary circulation in cancer of the breast and genitalia]. / Stsintigrafiia v otsenke posleoperatsionnykh narushenii legochnogo krovotoka pri rake molochnoi zhelezy i genitalii.

Altogether 60 patients with genital tumors and breast cancer were examined on the 3rd-7th day after operation using ON-110 gamma-camera (USA). Perfusion pulmonary scintigraphy with labeled MMA was performed in all the patients. In 66% of the examinees pulmonary blood flow disorders localized mainly in the lower part of the lungs, were noted, and in breast cancer patients--on the tumor lesion side, too. Perfusion pulmonary scintigraphy was shown to be an informative method of diagnosis of postoperative changes of the capillary pulmonary circulation which were clinically undetectable.

[Radioimmunological methods in the diagnosis of metastases of thyroid cancer]. / Radioimmunologicheskie metody v diagnostike metastazov raka shchitovidnoi zhelezy.

The concentrations of thyrotropin, thyroglobulin, calcitonin and carcinoembryonic antigen were raised in the blood of thyroid cancer patients. The occurrence of relapses of regional and distant metastases was accompanied by a sharp increase in the levels of thyrotropin, thyroglobulin and carcinoembryonic antigen permitting the recommendation of these tests for the diagnosis of distant metastases in the absence of local spread of a process. Simultaneous determination of the levels of thyroglobulins and carcinoembryonic antigen was the most informative for defining metastatic involvement of the osseous system.

[67Ga-citrate in the diagnosis of lung diseases]. / 67Ga-tsitrat v diagnostike zabolevanii legkikh.

Altogether 214 patients with different pulmonary diseases were examined using 67Ga-citrate scintigraphy. A high sensitivity of the method (94%) in the diagnosis of primary lung cancer and its high specificity (81.8%) in differential diagnosis of lung cancer and chronic non-specific lung diseases were established. The use of "positive" lung scintigraphy with 67Ga-citrate for diagnosis of metastatic pulmonary lesions as a result of a low sensitivity of the method in this pathology was found inappropriate. Differential diagnosis of lung cancer and acute inflammatory process by two investigations with 67Ga-citrate before and after a course of antibacterial and antiinflammatory therapy turned out possible; the preservation of a focus of raised accumulation of tumoritropic RP was typical of lung cancer whereas the disappearance of a focus or a decrease in the level of RP accumulation was typical of an acute inflammatory process.

[Scintigraphy of the bone marrow with 111In-citrin in polycythemia vera]. / Stsintigrafiia kostnogo mozga s 111In-tsitrinom pri istinnoi politsitemii.

Scintigraphy of the bone marrow with 111In-citrin was performed in 32 patients with polycythemia vera and 8 controls. The method ensured an objective assessment of bone marrow function in patients with polycythemia vera. A characteristic RP scintigraphic picture corresponded to different clinical stages of the disease. A degree of a decrease in the blood radioactivity within 24 h after i. v. administration of 111In-citrin reflected the summary erythropoietic activity of the bone marrow and could serve as a differential diagnostic criterion in determining a stage of polycythemia vera.