ABSTRACT
Mujer de 28 años de edad que presenta máculas y pápulas de aspecto atrófico, asintomáticas, localizadas en tronco y extremidades superiores de 8 años de evolución. Se realizó escisión-biopsia de una de las lesiones que reveló mediante tinción de orceína una disminución y fragmentación de las fibras elásticas en dermis reticular. Se descartaron posibles causas y asociaciones diagnosticándose de anetodermia primaria. Destacamos este caso por ser poco común en la clínica y proponemos la elaboración de un protocolo de actuación ante una anetodermia
A 28 years old woman who complains because the presence of atrophic macules and papules appearing progresivelly in the last 8 years is reported. The lesions were asymptomatic and they were located in the trunk and arms. An excisional biopsy was performed. Ordein stain revealed an important decrease and destruction of the elastical tissue in reticular dermis. Posible related causes and associated conditions were excluded and the diagnose of a primary anetoderma were stablished. We like to emphasize this case report because it is an uncommon disease and at the same time we propose a medical protocol for its study
Subject(s)
Female , Adult , Humans , Antibodies, Antiphospholipid/analysis , Skin Diseases/classification , Skin Diseases , Elastic Tissue/pathology , Connective Tissue/pathology , Immunohistochemistry , Biopsy, Needle , AtrophyABSTRACT
Presentamos 2 pacientes de sexo femenino con granuloma anular generalizado confirmado histológicamente, sin respuesta a terapéuticas previas con corticoides tópicos, corticoides orales, inmunomoduladores, retinoides e inmunosupresores. En ambos casos se ha instaurado tratamiento con vitamina E, tópica en uno y oral en otro, con evolución favorable. En ningún caso se ha observado recurrencia de la dermatosis. Pensamos que el tratamiento con vitamina E, podría ser una posible alternativa a tener en cuenta ante granulomas anulares generalizados recalcitrantes
We present 2 female patients with generalized granuloma annulare confirmed histopathologically with no improvement after topical and oral steroids, immunomodulators, retinoids and immunosuppressive drugs. Vitamin E therapy was successfully performed in both cases, topical in the first one and oral in the other, with no following recurrence. We think that topical or oral vitamin E are possible alternatives to consider in the treatment of recalcitrant generalized granuloma annulare
