Deformities of the nasal septum in human foetuses.

In a seris of 50 embryos and foetuses ranging from 20 mm to 190 mm in length two foetuses of 34 and 37 mm (48 to 50 days old) were found, that presented deformities of the septum of the cartilaginous nasal capsule, representing 4% of our material. The deformities consisted of curves of the nasal septum, located to both vomeronasal nerves. We therefore think that this study is interesting because it adds a new factor, the congenital one, to the etiology of deformities of the nasal septum.

[The effect of androgens upon the differentiation of Cowper and Bartholin glands in rat fetuses (author's transl)]. / Efecto de los andrógenous sobre la diferenciación de las glándulas de Cowper y Bartholin en fetos de rata.

In the present paper, a study is made of the normal structure shown in Bartholin and Cowper glands of 100 female fetuses and 100 male fetuses of Wistar rats at the end of gestation, with the structure of bulbouretral glands that formed in 70 female fetuses of the same species and period of gestation masculinized by androgens. In relation to the Bartholin glands, whose bilateral sketch is constant in the fetuses, we can affirm that it shows significant differences of structure with regards to the sketch of the Cowper gland. On the opposite, the histologycal details of the latter, are entirely identical to those shown by the bulbouretral glands of the masculinized female fetuses, a fact which permits us to affirm that these are authentic Cowper glands, not only because of their position, but also because of their structure. This morphological data corresponds to a masculinization phenomenon and demonstrates that the Bartholin and Cowper glands are very sensitive to the effect of androgens during gestation.

Contribution to the study of the development of the terminal portion of the Wolffian duct and the ureter.

Ten human embryos ranging from 10 to 20 mm in vertex-coccyx length (Horizons XVI and XVII Streeter) aged between 33 +/- 1 and 39 +/- 1 days, were studied in order to interpret the mechanism which determines the displacement of the ureter from the dorsal part of the Wolffian duct toward the lateral wall of the bladder. We demonstrated that this movement occurs due to the fact that the duct common to the ureter and the Wolffian duct undergoes a process of internal rotation before it is absorbed by the urogenital sinus. This determines that the ureteral orifice enter the urogenital sinus laterally with respect to the Wolffian duct. This absorption indicates that the mucosa of the trigone is of mesoblastic origin and the remainder of the besical of endoblastic origin. The origin of the muscular apparatus of the detrusor is entirely mesoblastic.