ABSTRACT
Oral lesions in the context of lupus erythematosus (LE) have long been described. However, definitive agreement on about the exact nature and correct classification of these manifestations is lacking in published studies. Controversy exists on the significance of oral LE lesions regarding patient outcome. In this article, medical and dental literature on clinical and histopathological aspects of oral LE lesions are reviewed and critically discussed. A clinico-pathological correlation of oral lesions (interface mucositis-lupus mucositis) with cutaneous lesions (interface dermatitis-lupus dermatitis) is established, for those represent the mucosal counterparts of cutaneous LE. Validity about widely used but imprecise terms such as "oral ulcers", "ulcerative plaques", and others, in the context of LE, is discussed, and the uncertain relationship of these alterations to systemic disease with a worse outcome is commented. Furthermore, insights about the nature, differential diagnosis, and prognosis of oral lesions in LE patients are presented.
Subject(s)
Lupus Erythematosus, Cutaneous/diagnosis , Lupus Erythematosus, Systemic/diagnosis , Female , Humans , Lupus Erythematosus, Cutaneous/classification , Lupus Erythematosus, Cutaneous/pathology , Lupus Erythematosus, Systemic/classification , Lupus Erythematosus, Systemic/pathology , Male , Oral Ulcer/classification , Oral Ulcer/pathologyABSTRACT
Discoid lupus erythematosus is much less frequent and studied in children. We undertook a retrospective study of 34 children less than 16 years of age with this disease, seen over a period of 9 years. A female predominance of 2:1 was found. An association between discoid lupus erythematosus and systemic lupus erythematosus was observed in 23.5% of patients, a higher proportion compared to adult discoid lupus erythematosus. Disseminated lesions were much more frequent in patients with criteria for systemic lupus erythematosus (87.5% vs 34%), suggesting that it could be associated with a worse prognosis. Histologic findings were similar to those observed in adult discoid lupus erythematosus.
Subject(s)
Lupus Erythematosus, Discoid/diagnosis , Lupus Erythematosus, Discoid/epidemiology , Adolescent , Age Distribution , Age of Onset , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Lupus Erythematosus, Discoid/genetics , Lupus Erythematosus, Discoid/pathology , Male , Medical History Taking , Retrospective Studies , Sex Distribution , Skin/pathologyABSTRACT
O angiohistiocitoma com células multinucleadas é dermatose vascular benigna, caracterizada pela presença de múltiplas pápulas eritêmato-violáceas, agrupadas, acometendo preferencialmente alguma extremidade. Sua histologia evidencia hiperplasia vascular com proliferação de células do tecido conjuntivo, associada à presença de células gigantes multinucleadas. Acomete principalmente mulheres após a quarta década de vida. Relata-se o primeiro caso dessa entidade na América Latina e discute-se os principais aspectos clínicos, histopatológicos e imuno-histoquimicos
Subject(s)
Humans , Female , Adult , Giant Cells/ultrastructure , Perna , Skin Diseases, Vascular , Vascular Neoplasms , Dendritic Cells/ultrastructure , Diagnosis, Differential , Immunohistochemistry , Sarcoma, Kaposi/diagnosis , Skin Diseases/diagnosis , Vascular Neoplasms/diagnosis , Vascular Neoplasms/etiology , Vascular Neoplasms/pathologyABSTRACT
One hundred and twenty-six patients with LE were studied. They were distributed as follows: 84 with DLE, 13 with SALE and 29 with SLE. Biopsies from the skin lesions were performed and submitted to DIF. Positive results were equal to 69,61.5 and 72.4 percent of the DLE,SALE and SLE cases, respectively. These data are in accordance with the literature. IgM was the most frequently found immunoglobulin, followed by the association IgM+C3.
