[Risk factors for hepatitis C among injecting drug users in Oslo]. / Risikofaktorer for hepatitt C-smitte blant sprøytemisbrukere.

BACKGROUND: Hepatitis C virus (HCV) infection is common among injecting drug users. The aims of this study were to assess the prevalence of risk behaviour and its association with HCV infection. MATERIAL AND METHODS: All users of the needle exchange program in Oslo, within a given time period, were eligible for inclusion in this cross-sectional study; 327 chose to participate. The users were asked about type of drug use and risk behaviour for HCV exposure in a structured interview. Sera were drawn and tested for anti HCV (EIA-3) and HCV RNA (in- house PCR). RESULTS: The prevalence of HCV RNA was 51 % and 81 % had anti-HCV. A multivariate analysis revealed positive associations between anti-HCV positive status and age < 20 years at first injection, > 5 years of drug use, age > 34 years, sharing of syringes, injecting drug use while imprisoned, back-loading and use of heroin. One in five users with anti-HCV reported to never have shared syringes. However, sharing of drug paraphernalia other than needles was not associated with anti-HCV. Sharing of needles the last four weeks before the interview was more common among those living with a partner than those who lived alone. INTERPRETATION: Most injecting drug users in Oslo have been exposed to HCV (anti HCV+) and half of them have developed chronic infection (HCV RNA+). HCV was associated with back-loading and sharing of syringes - especially during incarceration. Sharing of injection paraphernalia was not associated with being anti HCV positive.

[Overweight among eight and twelve-year-old children in Oslo in 2004]. / Overvekt hos åtte- og 12-åringer i Oslo i 2004.

BACKGROUND: Overweight among children is an increasing problem internationally. The body mass index of the parents and their children influences body mass index during adulthood and the probability of overweight and obesity. The aim of this survey was to obtain reliable data on weight and height for eight and twelve-year-olds in Oslo. MATERIAL AND METHODS: School health nurses in Oslo took measurements of the children's weight and height. The survey includes 3453 eight-year-olds and 3597 twelve-year-olds. RESULTS: The prevalence of overweight among eight-to-twelve-year-olds is 21%. There is a significant difference in the prevalence of overweight children between the local districts of Oslo. One in four of eight-year-old and one in five of twelve-year old girls are overweight. There is no significant difference between boys in different age groups. INTERPRETATION: The prevalence of overweight among eight to twelve-year-old children in Oslo is alarming. There are big differences between districts.

[Prevalence of genital Chlamydia trachomatis infection in the age group 18-29 years in Oslo]. / Forekomst av genital infeksjon med Chlamydia trachomatis blant 18-29-åringer i Oslo.

BACKGROUND: Earlier Norwegian prevalence studies of genital C. trachomatis infection have mainly been carried out among women and in selected patient groups. We decided to do a population-based prevalence study among young men and women in Oslo. The study was done within the framework of the new Norwegian list patient system, in which each citizen is assigned to one particular doctor. METHODS: Cross-sectional study. All patients 18-29 years old listed with a group practice in Oslo received a personal letter of invitation. We asked each person to submit a urine sample and fill in a questionnaire. The urinary samples were tested by means of a DNA amplification method. Non-respondents received one reminder. RESULTS: 685 persons were invited to participate, 234 responded (36%); 169 females (43%) and 65 males (25%). A total of 6 respondents (3%, 95% CI 1.2-5.5) tested positively, 4 of them were males. At least 51% of the females and 25% of the males had previously been examined for C. trachomatis, and at least 18% of the females and 8% of the males had received treatment. A total of 70% stated that they would see their doctor if they suspected a genital chlamydial infection. INTERPRETATION: Opportunistic testing for C. trachomatis infection should be offered more frequently to young men. A national prevalence study of genital chlamydial infection should be carried out. The new list patient system offers new opportunities for research in primary medical care in Norway.

A two-step medically based injury surveillance system--experiences from the Oslo injury register.

This paper presents a two-step injury surveillance system. In the first step, limited data (a minimum data set) on all (or a representative sample of all) injuries to residents and non-residents within a defined geographical area were obtained using routine collection procedures within the medical care system. The second step involved periodically sampling of specific injuries, injured persons, or places for in-depth investigations from the database established by the first step, or selecting relevant injured persons seeking treatment in the medical care system, to collect many data (an expanded data set) on a limited number of injuries. This system was implemented in Oslo. Data from about 48,000 injuries were collected annually. Two in-depth investigations of serious occupational injuries were carried out. The first involved 223 cases and the second, 50 cases. Some in-site studies were included. Experiences from the implementation in Oslo suggest that this system can function in the medical care system and provide data required for making estimates of injury incidence rates, establishing trends, and on contributing factors to injuries. A crucial factor in the success of the first part of such a system is to have enough resources for continuous quality control and feedback to personnel involved in the registration of data. Combining the registered data from general practitioners, accident and emergency departments, hospitals and notifications of fatalities in Oslo, and on assessments of the number of injuries treated by private clinics and occupational health centres in Oslo, and in the health care system outside of Oslo, leads to the conclusion that 11.9% of the residents of Oslo will annually be treated for an injury.

Health-related quality of life in active injecting drug users with and without chronic hepatitis C virus infection.

This study assessed the effect of chronic hepatitis C virus (HCV) infection on the health-related quality of life (HRQOL) of injecting drug users, comparing the HRQOL of injecting drug users with and without chronic HCV infection. The study included 199 injecting drug users of more than 18 years of age who participated in a needle exchange program. Blood samples were tested for the presence of HCV RNA in serum with a polymerase chain reaction method. HRQOL was measured using the questionnaire SF-36, measuring HRQOL over the last 4 wk. The HCV RNA test was positive in 102 (51%) and negative in 97 (49%) subjects. The HRQOL scores of actively injecting drug users were markedly reduced compared to the population norm. However, we did not find poorer HRQOL in injecting drug users with chronic HCV infection than in injecting drug users without HCV infection. HCV RNA positive injecting drug users who were aware of the infection had lower HRQOL scores than those unaware of the infection in 4 of the 8 SF-36 dimensions (general health, physical functioning, physical role, and vitality). HCV RNA negative subjects, who believed they were infected, scored worse in one dimension (general health) compared to those who did not believe they were infected. In conclusion, chronic HCV infection per se did not negatively affect the HRQOL of active injecting drug users. Those who thought they were infected had a lower HRQOL scores than those who believed they were not infected.