ABSTRACT
The effect of autotransplantation of the left lung on respiratory regulation was studied in four dogs in pentobarbital anaesthesia. In each dog the electrical and mechanical activity of the inspiratory muscles was studied before and 4-6 weeks, 3, 6 and 12 months after the transplantation. No or very little change was found in comparisons of spontaneous respiration or response to inhalation of carbon dioxide, hypoxia or combined hypercapnia and hypoxia. When the airways were closed after inflation with varying volumes of air, the increase in number and frequency of the electromyographic impulses in the intercostal muscles and the diaphragm (compared with the preceding unobstructed breaths) was greater before than after the lung autotransplantation. The duration of the first respiratory cycle after airway closure increased progressively with the volume of inflation in intact dogs and in dogs with autotransplanted left lung, though the increase was approximately halved following autotransplantation.
Subject(s)
Lung Transplantation , Respiration , Animals , Carbon Dioxide/pharmacology , Dogs , Lung/innervation , Lung/metabolism , Lung Volume Measurements , Oxygen , Pulmonary Stretch Receptors , Pulmonary Ventilation , Respiratory Center/physiology , Respiratory Function Tests , Transplantation, AutologousSubject(s)
Lung Volume Measurements/methods , Pulmonary Diffusing Capacity/methods , Adolescent , Adult , Carbon Monoxide/analysis , Female , Helium/analysis , Humans , Male , Middle Aged , Plethysmography, Whole Body/methods , Reference Values , Residual Volume , Spirometry/methods , Total Lung CapacityABSTRACT
Reference spirometric values for vital capacity (VC), forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory volume in one second as percentage of vital capacity or of forced vital capacity (FEV%), the highest flow during forced inspiration (Vmax insp), the highest forced expiratory flow at 50% vital capacity (Vmax 50%), the highest forced expiratory flow when 75% of vital capacity has been expired (Vmax 25%), Vmax insp/Vmax 50% and peak expiratory flow (PEF) were determined in a series of 296 males and 257 females, 18-65 years old, who have never smoked. Equations were derived using height and age as predictors. The reproducibility was tested.
Subject(s)
Respiratory Function Tests , Adolescent , Adult , Age Factors , Female , Forced Expiratory Flow Rates , Forced Expiratory Volume , Humans , Male , Middle Aged , Reference Values , Spirometry , Vital CapacityABSTRACT
Obstructive lung disease in two patients with Behcet's syndrome is presented. In both cases increased airways resistance, impaired PEF and FEV1.0 were found. In addition, diffusion capacity was slightly decreased in spite of enlarged total lung capacity and increased residual volumes. Both patients had mild hypoxaemia despite slight hyperventilation; a normal chest X-ray, and a decreased serum complement C3 level. Corticosteroids had a beneficial effect on VC in one of the two cases but failed to have any significant effect on the impaired ventilatory function in the other.
