ABSTRACT
The concentrations of gamma-aminobutyric acid (GABA), the activities of L-glutamate decarboxylase and GABA-transaminase, and the nature of the sodium-independent binding of GABA were examined in uterine tissue pieces obtained surgically from pregnant and non-pregnant women. GABA concentrations were reduced, while the activity of GABA-transaminase and the specific binding of [3H]GABA significantly increased in specimens from pregnant subjects. These findings suggest some gestation-related functional role for the GABA system in the human uterus.
Subject(s)
Pregnancy/metabolism , Receptors, GABA-A/metabolism , Uterus/metabolism , gamma-Aminobutyric Acid/physiology , 4-Aminobutyrate Transaminase/metabolism , Binding, Competitive , Female , Glutamate Decarboxylase/metabolism , HumansABSTRACT
The concentration of gamma-aminobutyric acid (GABA), the activities of related enzymes, i.e. glutamate decarboxylase and GABA transaminase, as well as the level of specific GABA binding sites were determined in ovaries and fallopian tubes obtained surgically from 31 women. None of the biochemical parameters examined showed a correlation with the age and hormonal background (serum estradiol and progesterone levels) of the patients. The respective ovarian and tubal values did not differ significantly in groups operated on because of uterine myoma and carcinoma. In organs from pregnant women, however, most GABAergic markers altered significantly. These findings indicate some gestation-related role for the ovarian and tubal GABA systems in humans.
Subject(s)
4-Aminobutyrate Transaminase/pharmacology , Aminobutyrates/pharmacology , Fallopian Tubes/drug effects , Glutamate Decarboxylase/pharmacology , Ovary/drug effects , Receptors, GABA-A/pharmacology , Adult , Binding Sites , Biomarkers , Female , Humans , Middle AgedABSTRACT
Ampicillin (Cymbi -Dolorgiet) was administered in various administration forms to 139 patients with acute and chronic infections of the urinary tract, biliary tract and other infections for an average of 10 days under conditions similar to those of general practice. In a controlled investigation the efficacy and tolerance were examined, and in parallel studies the in vitro activities were correlated with the blood levels obtainable in vivo to determine the therapeutic value in the treated group. The chemotherapeutic efficacy was high and the tolerance was good. The incidence of side effects was relatively low. Only 3;5% of the patients showed unfavorable results or had to stop the treatment.
