1.
Org Lett
; 14(17): 4634-7, 2012 Sep 07.
Article
in English
| MEDLINE
| ID: mdl-22920858
ABSTRACT
The total synthesis of the indole alkaloid hirsutine has been achieved, with a key step being the application of our phosphine-catalyzed [4 + 2] annulation of an imine with ethyl α-methylallenoate. From commercially available indole-2-carboxaldehyde, the target was synthesized in 14 steps and 6.7% overall yield.