ABSTRACT
OBJECTIVE: This study evaluated single intra-articular injections of Hymovis MO.RE., a hyaluronic acid hexadecyl derivative (HYADD4-G), to manage post-traumatic or degenerative knee or ankle chondropathy in professional soccer players. PATIENTS AND METHODS: Twenty-five players affected by knee (n = 12) or ankle (n = 13) chondropathy were prospectively enrolled and treated by two single Hymovis MO.RE. (32 mg/4 ml) injections at the beginning of the football season (V0, baseline) and at mid-season (V1, 19-20 weeks thereafter), and were followed-up until the end of the season (V2, after further 19-20 weeks). Knee cases were evaluated using the 2000 IKDC knee subjective examination form and the modified Lysholm scoring system. Ankle cases were evaluated using the American Orthopaedic Foot Ankle Society (AOFAS) ankle-hindfoot score. Patients were also evaluated using a VAS Likert scale and a four-category scale recording both the patient's and the doctor's assessment on joint mobility in degrees and overall treatment efficacy. Adverse events, patient withdrawals and local reaction to injections were also assessed. RESULTS: In knee patients, the 2000 IKDC subjective score improved from 46.8 ± 11.4 at V0 to 83.1 ± 12.5 at V2. Their modified Lysholm score improved from 58.8 ± 8.9 at V0 to 90.6 ± 8.3 at V2. In the ankle patients, the AOFAS score improved from 52.2 ± 5.6 at V0 to 96.4 ± 4.5 at V2. VAS Likert values and subjective evaluations improved at V1 and were maintained at V2. No side effects were recorded. CONCLUSIONS: A single Hymovis MO.RE. (32 mg/4 ml) intra-articular injection, repeated after 19-20 weeks, may be a viable option to improve symptoms and function in professional soccer players suffering from knee and ankle chondropathy.
Subject(s)
Ankle Joint/drug effects , Cartilage Diseases/drug therapy , Hyaluronic Acid/administration & dosage , Knee Joint/drug effects , Ankle Joint/physiopathology , Athletes , Cartilage Diseases/physiopathology , Cohort Studies , Follow-Up Studies , Humans , Hyaluronic Acid/adverse effects , Injections, Intra-Articular , Knee Joint/physiopathology , Prospective Studies , Range of Motion, Articular , Soccer , Treatment OutcomeABSTRACT
The peritrophic matrix (PM) is a chitin-containing acellular sheath that surrounds the blood meal and separates the food bolus from the midgut epithelium. Intense molecular traffic through the PM occurs during digestion. Digestive enzymes secreted by the midgut epithelium must traverse the PM to reach their substrates in the food bolus, and digestion products must cross the PM in the opposite direction to be absorbed by the epithelial cells. Here we report that the PM limits the rate of digestion. PM disruption by two independent means (chitinase and anti-PM antibodies) consistently increases the rate of blood digestion. The significance of these results in relation to PM function is discussed.
Subject(s)
Aedes/metabolism , Anopheles/metabolism , Animals , Chitin/metabolism , Chitinases/metabolism , Digestive System/enzymology , Digestive System/metabolism , Female , Oviposition/physiologyABSTRACT
No disponible
No disponible
Subject(s)
Humans , Tobacco Use Cessation/methods , Hot Temperature/therapeutic use , Infrared Rays/therapeutic useABSTRACT
La urolitiasis constituye una patología frecuente comprometiendo en series extranjeras, entre un 5 a 10 por ciento de la población. Su incidencia se desconoce en nuestro país, sin embargo, se espera que aumente al incrementar el ingreso per capita en Chile. El objetivo de este trabajo es estimar la contribución de los distintos exámenes de imagen utilizados en el estudio diagnóstico de los pacientes que ingresan a nuestro hospital por cólico renal. Estudio retrospectivo de todos los pacientes que ingresan por el servicio de urgencia del Hospital Clínico de la Universidad Católica con el diagnóstico de cólico renal, entre octubre 1998 y julio 1999. Se evaluaron los distintos estudios de imagen que llevaron al diagnóstico y que determinan la conducta definitiva, considerando el tiempo necesario para su estudio. La serie se compone de 124 pacientes consecutivos, 67 por ciento son varones con una edad promedio de 35,3 años (16 a 67 años). Se encuentra en 87 casos (70,2 por ciento) alteraciones secundarias a urolitiasis, constatándose el cálculo en 80 de ellos (64,5 por ciento) siendo la ubicación más frecuente en uréter distal (65 por ciento). El estudio de imagen inicial fue la Pielografía en 91 casos (73,4 por ciento), entregando el diagnóstico como primer estudio en 81 (65,3 por ciento) con un tiempo promedio de diagnóstico de 1,9 días. La Ecotomografía se empleó en un total de 21 casos, utilizándose en un 17 por ciento de las mujeres y en 8,4 por ciento de los hombres como primer examen. Pielo TAC se solicitó en un total de 9 casos en 7, como primer examen. En total se realizaron 121 Pielografía sin registrarse morbilidad en esta serie. La Pielografía constituye el examen que con mayor frecuencia entregó el diagnóstico, permitiendo indicar un tratamiento en un tiempo breve y sin morbilidad
Subject(s)
Humans , Male , Adult , Female , Middle Aged , Colic/diagnosis , Kidney Diseases , Urography , Abdomen , UltrasonographyABSTRACT
An infant with unusual CT and MRI manifestations of postnatally acquired cytomegalovirus (CMV) infection is presented. The child exhibited extensive inflammatory lesions in the periventricular area and at the level of the quadrigeminal plate with the formation of a pseudotumour at this level. The latter produced aqueduct obstruction resulting in hydrocephalus. These findings have not previously been described in the literature.
Subject(s)
Cytomegalovirus Infections/diagnosis , Encephalitis, Viral/diagnosis , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Cerebral Aqueduct/diagnostic imaging , Cerebral Aqueduct/pathology , Cerebral Aqueduct/virology , Cerebral Ventricles/pathology , Cerebral Ventricles/virology , Cerebral Ventriculography , Contrast Media , Cytomegalovirus Infections/diagnostic imaging , Encephalitis, Viral/diagnostic imaging , Gadolinium , Gadolinium DTPA , Humans , Hydrocephalus/diagnosis , Hydrocephalus/diagnostic imaging , Hydrocephalus/virology , Infant , Male , Organometallic Compounds , Pentetic Acid/analogs & derivatives , Tectum Mesencephali/diagnostic imaging , Tectum Mesencephali/pathology , Tectum Mesencephali/virologySubject(s)
Cranial Nerve Neoplasms/pathology , Facial Nerve/pathology , Magnetic Resonance Imaging , Neurilemmoma/pathology , Tomography, X-Ray Computed , Aged , Cranial Nerve Neoplasms/complications , Cranial Nerve Neoplasms/surgery , Facial Nerve/surgery , Facial Nerve/ultrastructure , Facial Paralysis/etiology , Humans , Neurilemmoma/complications , Neurilemmoma/surgeryABSTRACT
The effects of L-carnitine on the pyruvate dehydrogenase (PDH) complex and carnitine palmitoyl transferase (CPT) were studied in muscle of 16 long-distance runners (LDR). These subjects received placebo or L-carnitine (2 g orally) during a 4-week period of training. Athletes receiving L-carnitine showed a dramatic increase (P < 0.001) in the PDH complex activities. By contrast, the levels of CPT, both 1 and 2, were unchanged. No significant changes were observed after placebo administration. We previously reported [Huertas R. et al., Biochem. Biophys. Res. Commun. 188 (1992) 102-107] that L-carnitine induces an increase in the activities of complexes I, III and IV of the respiratory chain in muscle of LDR. Taken together, our data suggest that the improvement in (maximal oxygen consumption) VO2max observed in LDR after L-carnitine administration is based on these biochemical findings.
