Real-world data of non-invasive stimulation of the human insula-prefrontal cortices using deep TMS to treat anxiety for occupational stress and generalized anxiety disorder.

Activation of the insula is found in all anxiety-related disorders and increased insular-prefrontal cortex (PFC) functional connectivity is associated with reduced anxiety. In this study, the combined stimulation of the insula and PFC using the dTMS H4 (insula+LPFC) and H2 (PFC) coils were used to reduce anxiety in 13 subjects experiencing occupational stress, and 55 participants suffering from generalized anxiety disorder (GAD). The combined HF stimulation of the insula and PFC significantly decreased anxiety scores according to the HARS, CAS, and STAI anxiety scales, leading to a reduction in anxiety according to HARS of 88.7% and 70.7% in participants with occupational stress and the clinical sample of participants diagnosed with GAD, respectively. The findings suggest that the prefrontal-insular axis is critical for the regulation of anxiety and its stimulation can be used for the treatment of anxiety in people suffering from occupational stress and GAD.

Utilidad del uso de povidona yodada asociada a quimioprofilaxis en biopsia prostática transrectal / Efficacy of prophylactic povidone-iodine rectal cleansing in transrectal prostate biopsy

Introducción: La infección prostática y/o sistémica asociada a la Biopsia Prostática Transrectal (BPTR), es conocida y temida, por ser una complicación grave y potencialmente mortal. En el presente trabajo se analiza el impacto del uso de enema de Povidona Yodada Rectal en asociación a Quimioprofilaxis en la tasa de Infecciones Prostáticas y/o Sepsis secundaria.(AU)