1.
Cancer Genet Cytogenet
; 203(2): 345-7, 2010 Dec.
Article
in English
| MEDLINE
| ID: mdl-21156257
Subject(s)
Chromosome Aberrations , Chromosomes, Human, Pair 5 , Chromosomes, Human, Pair 8 , Multiple Myeloma/complications , Multiple Myeloma/genetics , Myelodysplastic Syndromes/complications , Myelodysplastic Syndromes/genetics , Trisomy , Aged , Chromosome Banding , Chromosome Deletion , Cytogenetics , Female , Humans , Karyotyping
2.
Cancer Genet Cytogenet
; 184(2): 122-3, 2008 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-18617063
Subject(s)
Cell Transformation, Neoplastic/genetics , Chromosome Inversion , Chromosomes, Human, Pair 3 , Thrombocythemia, Essential/complications , Bone Marrow Cells/pathology , Disease Progression , Humans , Karyotyping , Leukemia, Myeloid, Acute/genetics , Male , Middle Aged , Thrombocythemia, Essential/pathology
3.
Cancer Genet Cytogenet
; 180(1): 85-6, 2008 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-18068542
Subject(s)
Anemia, Refractory, with Excess of Blasts/complications , Anemia, Refractory, with Excess of Blasts/genetics , Chromosomes, Human, Pair 21 , Chromosomes, Human, Pair 8 , Core Binding Factor Alpha 2 Subunit/genetics , DNA-Binding Proteins/genetics , Proto-Oncogene Proteins/genetics , Transcription Factors/genetics , Translocation, Genetic , Aged , Humans , In Situ Hybridization , Karyotyping , Male , Oncogene Proteins, Fusion/genetics , RUNX1 Translocation Partner 1 Protein
4.
Cancer Genet Cytogenet
; 149(1): 11-6, 2004 Feb.
Article
in English
| MEDLINE
| ID: mdl-15104277
ABSTRACT
In two patients with hematological neoplasias a tandem repetition of chromosome 21 in the bone marrow was revealed by cytogenetic analysis. The disease was different in the two patients: one was of the lymphoid type, acute lymphoblastic leukemia type L1, and the other was of the myeloid type, acute nonlymphoblastic leukemia type M2. In one case this chromosomal abnormality resulted in amplification of the AML1 gene (HUGO nomenclature: RUNX1), whereas in the other case the AML1 gene was not included in the tandem repetition, showing that apparently similar cytogenetic aberrations may be different at the molecular level.
Subject(s)
Chromosomes, Human, Pair 21/genetics , DNA-Binding Proteins/genetics , Gene Amplification/genetics , Leukemia, Myeloid, Acute/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Proto-Oncogene Proteins/genetics , Tandem Repeat Sequences/genetics , Transcription Factors/genetics , Aged , Bone Marrow/pathology , Child, Preschool , Core Binding Factor Alpha 2 Subunit , Female , Humans , In Situ Hybridization, Fluorescence , Leukemia, Myeloid, Acute/pathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology
5.
Cancer Genet Cytogenet
; 139(1): 88-9, 2002 Nov.
Article
in English
| MEDLINE
| ID: mdl-12547169
