ABSTRACT
UNLABELLED: Data on the frequency of non-motor symptoms among patients with Parkinson's disease (PD) in Mexico has not been reported. OBJECTIVE: To study the prevalence of these symptoms in a sample of Mexican PD patients attending a referral neurologic center using the Non Motor Symptoms Questionnaire (NMSQuest) and the Non Motor Symtpoms Scale (NMSS). METHODS: One-hundred consecutive PD patients, of all ages and disease severity were included in a cross-sectional design study. The NMSQuest and NMSS were applied during the "on" state. RESULTS: Sample had a mean age of 64.5±10.9 years and disease duration of 6.6±4.8 years. Total NMSQuest median score was 10 and the mean NMSS score was 69.3±56.7. Positive answers classified by domain were as follows: gastrointestinal symptoms 30%, urinary symptoms 60%, memory/attention/apathy 39%, hallucinations/delusions 16%, depression/anxiety 55%, sexual dysfunction 30%, cardiovascular symptoms 35%, sleep disorders 40% and miscellany 27%. CONCLUSION: The prevalence of non-motor symptoms among mexican patients with PD is similar to other countries. Mood, cognitive and perceptual symptoms seems to be more severe in our population.
Subject(s)
Parkinson Disease/complications , Parkinson Disease/epidemiology , Adult , Aged , Aged, 80 and over , Antiparkinson Agents/therapeutic use , Cross-Sectional Studies , Dopamine Agonists/therapeutic use , Female , Humans , Levodopa/therapeutic use , Male , Mexico/epidemiology , Middle Aged , Parkinson Disease/physiopathology , Surveys and QuestionnairesABSTRACT
OBJECTIVE: To determine the metric properties of the non-motor symptoms questionnaire (NMSQuest), non-motor symptoms scale (NMSSS) and SCOPA-AUT clinimetric instruments to assess non motor dysfunction in Mexican population. MATERIAL AND METHODS: After linguistic validation, the instruments were applied to 100 consecutive Parkinson's disease patients to analyze its metric properties in Mexican out-patients from the National Institute of Neurology and Neurosurgery. RESULTS: Internal consistency by Cronbach's alpha was above 0.80 for all instruments. Inter-item and item-total correlations were above 0.30 in the majority of the domains and inter-observer variability was acceptable. Total score did not correlate with any of the registered clinical variables. CONCLUSION: The metric properties of the three instruments were acceptable and similar to published data from other countries.
Subject(s)
Parkinson Disease/physiopathology , Severity of Illness Index , Surveys and Questionnaires , Aged , Female , Humans , Language , Male , Mexico , Middle Aged , Outpatients , Reproducibility of ResultsABSTRACT
BACKGROUND: Friedreich's ataxia is the most common hereditary ataxia and its clinical spectrum includes cardiac disease, mainly hypertrophic cardiomyopathy. METHODS: We present two cases with molecular diagnosis of Friedreich's ataxia and cardiac disease shown on electrocardiogram and echocardiogram. RESULTS: Neurological symptoms which lead to the diagnosis are described together with cardiac comorbidities. CONCLUSIONS: The cases here described highlight the importance of early screening and identification of systemic complications, specifically cardiac disease, in patients with this neurological disease.
