ABSTRACT
Schistosomiasis is related to the development of liver fibrosis and portal hypertension. Chronic co-infection with HBV and Schistosoma has been associated in endemic areas with a higher risk for a more severe liver disease. However, no studies have assessed the real importance of this co-infection in non-endemic regions. This is a retrospective observational study of Sub-Saharan immigrants attending between October 2004 and February 2014. Patients with chronic HBV infection with and without evidence of schistosomal infection were compared. Epidemiological, analytical, and microbiological data were analysed. Likelihood of liver fibrosis based on APRI and FIB-4 indexes was established. A total of 507 patients were included in the study, 170 (33.5 %) of them harbouring evidence of schistosome infection. No differences were found in transaminase, GGT, and ALP levels. In fibrosis tests, a higher proportion of patients with HVB and S. mansoni detection reached possible fibrosis scores (F > 2) when compared to patients without schistosomiasis: 17.4 vs 14.2 % and 4.3 % vs 4.2 % (using high sensitivity and high specificity cut-offs respectively), although differences were not statistically significant (p = 0.69, p = 0.96). For possible cirrhosis (F4) score, similar results were observed: 4.3 % of co-infected patients vs 2.1 % of mono-infected ones, p = 0.46. According to these datas, in non-endemic regions the degree of hepatic fibrosis in patients with chronic hepatitis B is not substantially modified by schistosome co-infection.
Subject(s)
Coinfection/diagnosis , Hepatitis B, Chronic/complications , Hepatitis B, Chronic/diagnosis , Schistosomiasis/complications , Schistosomiasis/diagnosis , Adult , Africa South of the Sahara , Animals , Coinfection/epidemiology , Coinfection/pathology , Emigrants and Immigrants , Female , Hepatitis B, Chronic/epidemiology , Hepatitis B, Chronic/pathology , Humans , Liver Cirrhosis/diagnosis , Liver Cirrhosis/epidemiology , Liver Cirrhosis/pathology , Male , Retrospective Studies , Schistosomiasis/epidemiology , Schistosomiasis/pathology , Spain/epidemiology , Young AdultSubject(s)
Humans , Male , Middle Aged , Infarction/complications , Infarction/diagnosis , Anemia, Sickle Cell/complications , Anemia, Sickle Cell/diagnosis , Hemoglobinopathies/complications , Infarction/physiopathology , Infarction , Anemia, Sickle Cell , Primary Health Care/methods , Pain Management/methods , Magnetic Resonance Imaging/instrumentation , Magnetic Resonance Imaging/methods , HemoglobinopathiesSubject(s)
Fusarium/isolation & purification , Mycetoma/diagnosis , Mycetoma/microbiology , Humans , Male , Middle Aged , Mycetoma/pathology , Mycetoma/therapySubject(s)
Humans , Male , Adult , Mycetoma/complications , Mycetoma/diagnosis , Magnetic Resonance Imaging/methods , Magnetic Resonance Imaging , Fusarium/cytology , Fusarium/isolation & purification , Biopsy/methods , Itraconazole/therapeutic use , Mycetoma , Fusarium/radiation effects , Isoniazid/therapeutic use , Ethambutol/therapeutic use , Rifampin/therapeutic useABSTRACT
La inmigración es un fenómeno real en nuestro país, repercutiendo directamente en la sanidad. Al enfrentarnos ante pacientes de esta índole, no debemos olvidar la existencia de enfermedades inusuales en nuestro medio. Presentamos un caso clínico de un paciente con hematuria por esquistosomiasis urinaria. Así mismo realizamos una revisión de la literatura sobre la clínica, diagnóstico y tratamiento de esta enfermedad (AU)
