ABSTRACT
No disponible
Subject(s)
Male , Adult , Humans , Fever/etiology , Lymphatic Diseases/complications , Skin Ulcer/etiology , Diagnosis, DifferentialABSTRACT
No disponible
Subject(s)
Middle Aged , Female , Humans , Cryptogenic Organizing Pneumonia , Pneumonia, MycoplasmaABSTRACT
No disponible
Subject(s)
Middle Aged , Aged , Male , Female , Humans , Steroids , Myositis, Inclusion Body , Muscle, Skeletal , Retrospective Studies , Biopsy , Anti-Inflammatory AgentsABSTRACT
OBJECTIVE: To asses hearing loss in patients infected with the human immunodeficiency virus (HIV) and its relationship with clinical stage (fulfillment of diagnostic criteria for human acquired immunodeficiency syndrome/AIDS) and degree of lymphocyte depletion (number of CD4+ lymphocytes). METHODS: Assessment of thirty consecutive HIV-infected patients regarding the presence of subjective hearing loss, pure-tone audiometry, brain stem auditory evoked potentials (BAEP); and number of CD4+ lymphocytes and treatment with antiretroviral drugs. RESULTS: Forty percent of patients reported hearing loss; 33% had an abnormal audiometry and BAEPs were abnormal in 56% of patients. The most common findings included high-frequency sensorineural loss and an increase in the wave III latency and interaural I-V difference. Subjective hearing loss and an abnormal audiometry were both related to the administration of antiretroviral drugs, whereas abnormal BAEPs were related to AIDS and low CD4+ lymphocyte counts. CONCLUSIONS: In HIV infected patients, an abnormal BAEP is the most common audiologic disorder, particularly in the advanced stages of the disease.
Subject(s)
Deafness/etiology , HIV Infections/complications , Adult , Cross-Sectional Studies , Deafness/diagnosis , Deafness/epidemiology , Evoked Potentials, Auditory, Brain Stem , Female , Humans , Male , Middle AgedABSTRACT
Objetivo. Estudio de la hipoacusia en pacientes infectados por el virus de la inmunodeficiencia humana (VIH) y su relación con el estadio clínico (cumplimiento o no de los criterios de síndrome de la inmunodeficiencia adquirida [SIDA]) y el grado de depleción linfocitaria (número de linfocitos CD4). Método: Estudio de 30 pacientes consecutivos infectados por el VIH en los que se evaluó la presencia de hipoacusia subjetiva, audiometría tonal, potenciales auditivos evocados del tronco del encéfalo (PAETC), así como el número de linfocitos CD4 y la toma o no de medicación antirretrovírica. Resultados: El 40 por ciento de los pacientes estudiados refería hipoacusia en la anamnesis, en el 33 por ciento se evidenció una audiometría patológica y los PAETC se hallaron alterados en el 56 por ciento de los pacientes. Los hallazgos más frecuentes fueron la pérdida neurosensorial en las frecuencias agudas y el aumento de la latencia de la onda III, V y de la diferencia interaural I-V. La hipoacusa subjetiva y la audiometría patológica guardaron relación con la toma de antirretrovíricos y los PAETC con el diagnóstico de SIDA y con el número de linfocitos CD4. Conclusiones: En los pacientes con infección por el VIH la alteración de los PAETC fue el hallazgo auditivo más frecuente, especialmente en los estadios más avanzados de la enfermedad (AU)
Subject(s)
Middle Aged , Adult , Male , Female , Humans , HIV Infections , Evoked Potentials, Auditory, Brain Stem , Deafness , Cross-Sectional StudiesSubject(s)
Mastocytosis/diagnosis , Splenomegaly/diagnosis , Urticaria Pigmentosa/diagnosis , Aged , Biopsy , Bone Marrow/pathology , Humans , Lumbar Vertebrae/pathology , Magnetic Resonance Imaging , Male , Mastocytosis/pathology , Radiography, Thoracic , Skin/pathology , Splenomegaly/pathology , Time Factors , Tomography, X-Ray Computed , Urticaria Pigmentosa/pathologyABSTRACT
Three patients are reported who had systemic lupus erythematosus and membrane-proliferative glomerulonephritis. These patients failed to respond to intravenous cyclophosphamide and steroids and were then changed to receive oral cyclosporine A, at a dose of 5 mg/kg/day. The three patients showed remission of disease, symptoms, and renal and immunological parameters, with minimal secondary effects. The medical literature was reviewed and cyclosporine A is suggested to be a therapeutical choice for patients with lupus nephropathy even when they do not respond to other immunosuppressive regimes, such as pulse cyclophosphamide.