ABSTRACT
El suicido en adolescentes y jóvenes constituye un problema de salud mental pública que requiere el desarrollo de los correspondientes programas de intervención. Al respecto, se hizo un estudio de sistematización bibliográfica con enfoque cualitativo, empleando una estrategia de tipo PICO y los lineamientos básicos del modelo PRISMA. Se partió de la identificación de 237 artículos y luego de aplicar los diferentes filtros de selección se incluyeron 30 de estos. Los autores concluyeron que los programas de intervención en poblaciones con factores de riesgo y que se realizan en ambientes con mayor posibilidad de control, tales como: áreas de hospitalización y entornos escolares, incrementan sus probabilidades de efectividad en la disminución de la ideación y conducta suicida.
Suicide in adolescents and young people constitutes a public mental health problem that requires the development of the corresponding intervention programs. In this regard, a bibliographic systematization study was carried out with a qualitative approach, using a PICO-type strategy and the basic guidelines of the PRISMA model. It was started from the identification of 237 articles and after applying the different selection filters, 30 of these were included. The authors concluded that intervention programs in populations with risk factors and that are carried out in environments with a greater possibility of control (hospitalization areas and school environments) increase their probability of effectiveness in reducing suicidal ideation and behavior.
Subject(s)
Humans , Male , Female , Adolescent , Suicide , Adolescent , Suicidal Ideation , Behavior , Mental Health , Risk FactorsABSTRACT
BACKGROUND: Secretory phospholipase A2 receptor (PLA2R) is the target antigen of the auto-antibodies produced in most (â¼ 70%) patients with primary membranous nephropathy (pMN). The applicability of anti-PLA2R1 antibody monitoring for the prediction of MN recurrence in kidney transplant recipients still is a matter of debate. METHODS: We sought to characterize the presence and concentration of anti-PLA2R antibodies by enzyme-linked immunosorbent assay (ELISA) in a cohort of 21 patients with pMN before and after transplantation to evaluate whether anti-PLA2R concentrations could predict pMN recurrence. RESULTS: The presence of pMN recurrence was significantly correlated with the existence of a positive ELISA assay at graft biopsy or with high level of anti-PLA2R1 activity before transplantation (P = 0.03). In the receiver operating characteristic analysis, anti-PLA2R levels (cut-off of 45 U/mL) during the pretransplantation period accurately predicted pMN recurrence, with a sensitivity of 85.3%, specificity of 85.1%, negative predictive value of 92%, and an area under the curve of 90.8%. This finding supports the hypothesis that anti-PLA2R cause pMN recurrence in humans and indicates the need to prove in an experimental model. Furthermore, 6 of 7 patients with recurrence were carriers of HLA DQA1* 05:01/05 and DQB1* 02:01, confirming these DQ alleles as those associated with higher anti-PLA2R levels. CONCLUSIONS: This study is the first to demonstrate pretransplantation circulating anti-PLA2R antibodies in a cohort of renal transplant recipients who prospectively developed recurrent disease. Currently, anti-PLA2R levels measured by ELISA may be a rational tool to establish the risk of MN recurrence in renal allograft recipients.
Subject(s)
Autoantibodies/blood , Glomerulonephritis, Membranous/surgery , Kidney Transplantation/adverse effects , Receptors, Phospholipase A2/immunology , Adult , Aged , Area Under Curve , Biomarkers/blood , Biopsy , Enzyme-Linked Immunosorbent Assay , Female , Glomerulonephritis, Membranous/blood , Glomerulonephritis, Membranous/diagnosis , Glomerulonephritis, Membranous/immunology , HLA-DQ Antigens/genetics , HLA-DQ Antigens/immunology , Humans , Male , Middle Aged , Predictive Value of Tests , ROC Curve , Recurrence , Retrospective Studies , Risk Assessment , Risk Factors , Spain , Time Factors , Treatment OutcomeSubject(s)
Child Abuse, Sexual , Condylomata Acuminata/diagnosis , Vulvar Diseases/virology , Child, Preschool , Fathers , Female , HumansABSTRACT
BACKGROUND: In previous studies, nitazoxanide has demonstrated a cytoprotective effect against rotavirus, reducing the duration of diarrhea in comparison to placebo. We designed a randomized, single-blind, controlled trial in order to assess the effectiveness of nitazoxanide and probiotics in comparison with a control group. METHODS: Seventy-five children aged from 28 days to 24 months, with rotavirus diarrhea, were randomly assigned to receive either oral nitazoxanide (15 mg/kg/day) twice a day for three days, a combination of oral probiotics, 1 g twice a day for five days, or only oral or systemic rehydration solutions. The duration of diarrhea and of hospitalization were the primary outcome measures, and daily stool frequency, vomiting, and fever were some of the secondary outcome measures analyzed. RESULTS: The median duration of hospitalization was significantly shorter (p = 0.017) in patients who received nitazoxanide (81 h) and probiotics (72 h) compared to patients who received oral rehydration solution alone (108 h). Similarly, the median duration of diarrhea was significantly reduced (p = 0.009) in children who received nitazoxanide (54 h) and probiotics (48 h) compared to the control group (79 h). CONCLUSIONS: Treatment with nitazoxanide and probiotics is effective in the management of children with acute rotavirus diarrhea. Small differences in favor of nitazoxanide were found in comparison with probiotics. Nitazoxanide is an important treatment option for rotavirus diarrhea.
