Case Series of SMARCA4-Deficient Undifferentiated Esophageal Carcinoma.

Undifferentiated esophageal carcinomas (UEC) are rare, with aggressive behavior and a dismal prognosis. An extremely rare subset is the SMARCA4-deficient UEC, which has only been reported in 14 cases to date. We present two cases of male patients (39- and 64-year-old) with SMARCA4-deficient UEC. Both patients had evidence of metastatic disease on presentation, progressed rapidly, and passed away within three months from the presentation. We aim to raise awareness of this underreported disease and contribute to the exploration of the possible underlying pathology and risk factors.

Severe Gastrointestinal Bleeding Following Gastrostomy Tube Replacement: A Case of an Unusual Presentation of Enterocutaneous Fistula.

Gastrostomy tubes are widely used and provide an alternative route of enteral feeding when oral intake is not feasible. Previously, a surgical laparotomy was required for its placement, but percutaneous endoscopic gastrostomy and fluoroscopy-guided percutaneous radiological gastrostomy (PRG) techniques have widely replaced the surgical approach given their less invasive nature. Although the complications that might follow these procedures are usually minor, more severe complications can rarely occur. We describe a unique case of severe gastrointestinal bleeding in a patient who underwent PRG tube exchange reflecting an acute complication following an asymptomatic misplaced permanent gastrostomy tube.

A Challenging Case of Recurrent Eosinophilic Peritonitis.

Eosinophilic peritonitis is a rare presentation of eosinophilic gastroenteritis and is characterized by eosinophil-rich inflammation in any part of the gastrointestinal tract in the absence of secondary causes of eosinophilia. We report a case of a 48-year-old female who had recurrent hospital admissions due to abdominal pain and distension secondary to relapsing eosinophilic peritonitis.