Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Biomed Res Int ; 2015: 940278, 2015.
Article in English | MEDLINE | ID: mdl-25821830

ABSTRACT

BACKGROUND: In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment. PROCEDURE: This was a cohort study with a historical control group, forty patients, less than 16 years old. Group A (20 patients), diagnosed in the period 2005-2007, was treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy: high doses of cytarabine and mitoxantrone. Group B (20 patients), diagnosed in the period 1999-2004, was treated as Group A, but without the early intensified chemotherapy. RESULTS: Relapse-free survival for Group A was 90% whereas that for Group B it was 60% (P = 0.041). Overall survival for Group A (18, 90%) was higher than that for Group B (60%). Complete remission continued for two years of follow-up. CONCLUSIONS: Relapse-free survival for paediatric patients treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy was higher than that for those who did not receive early intensified chemotherapy.


Subject(s)
Antineoplastic Agents/therapeutic use , Leukemia, Myeloid, Acute/mortality , Leukemia, Myeloid, Acute/therapy , Stem Cell Transplantation/mortality , Stem Cell Transplantation/statistics & numerical data , Survivors/statistics & numerical data , Child , Child, Preschool , Combined Modality Therapy , Female , Humans , Infant , Longitudinal Studies , Male , Mexico/epidemiology , Risk Factors , Survival Rate , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...