ABSTRACT
Cerebral lesions after a stroke present different clinical features depending on the neurological structures affected. Complications after an injury in the respiratory center may lead to prolonged mechanical ventilation. Among these possible complications there is a rare neurological condition called "Ondine's curse" that is caused by spontaneous breathing failure. Patients who suffer this syndrome cannot breathe automatically and need to control their respiration consciously and voluntarily. We report the case of a woman who developed a syndrome of central alveolar hypoventilation secondary to an injury in respiratory center after a hemorrhagic stroke. We have reviewed the etiology, physiopathology, diagnosis and treatment of patients with Ondine's curse.
Subject(s)
Hypoventilation/etiology , Ventilator Weaning , Adult , Female , Humans , Stroke/complications , Stroke/therapy , Treatment FailureABSTRACT
Las lesiones cerebrales secundarias a un ictus se manifiestan según la estructura neurológica afectada. Las complicaciones por afectación del centro respiratorio pueden ser causa de una ventilación mecánica prolongada. Entre estas complicaciones se encuentra la llamada «maldición de Ondine», que hace referencia a una rara enfermedad neurológica causada por el fallo en la respiración espontánea. Los pacientes no son capaces de respirar automáticamente, y necesitan consciente y voluntariamente realizar la respiración por ellos mismos. En este artículo presentamos el caso de una mujer que tras un ictus hemorrágico cerebeloso desarrolla un síndrome de hipoventilación alveolar central secundario a una lesión del centro respiratorio. Realizamos una revisión de la etiología, el mecanismo fisiopatológico, el diagnóstico y el tratamiento del síndrome de Ondine (AU)
Cerebral lesions after a stroke present different clinical features depending on the neurological structures affected. Complications after an injury in the respiratory center may lead to prolonged mechanical ventilation. Among these possible complications there is a rare neurological condition called «Ondine's curse» that is caused by spontaneous breathing failure. Patients who suffer this syndrome cannot breathe automatically and need to control their respiration consciously and voluntarily. We report the case of a woman who developed a syndrome of central alveolar hypoventilation secondary to an injury in respiratory center after a hemorrhagic stroke. We have reviewed the etiology, physiopathology, diagnosis and treatment of patients with Ondine's curse (AU)
Subject(s)
Humans , Female , Adult , Ventilator Weaning , Hypoventilation/etiology , Stroke/complications , Stroke/therapy , Treatment FailureSubject(s)
Blood Platelet Disorders/etiology , Blood Platelets/physiology , Cystic Fibrosis/blood , Cystic Fibrosis/complications , Ischemia/etiology , Adult , Blood Platelet Disorders/blood , Blood Platelet Disorders/drug therapy , Female , Humans , Ischemia/blood , Ischemia/drug therapy , Platelet Aggregation Inhibitors/therapeutic use , Tomography, X-Ray ComputedABSTRACT
No disponible
No disponible
Subject(s)
Adult , Female , Humans , Blood Platelet Disorders/etiology , Blood Platelet Disorders/physiopathology , Cystic Fibrosis/blood , Cystic Fibrosis/complications , Ischemia/etiology , Blood Platelet Disorders/blood , Blood Platelet Disorders/drug therapy , Ischemia/blood , Ischemia/drug therapy , Platelet Aggregation Inhibitors/therapeutic use , Tomography, X-Ray ComputedABSTRACT
Los pacientes con enfermedades del espectro esquizofrénico son más obesos que la media de la población. En este dato epidemiológico colabora la propia enfermedad (debido a alteraciones centrales de los neurotransmisores relacionados con la saciedad), potenciada por la acción de algunos antipsicóticos (clozapina, olanzapina, etc.). Asimismo, la mortalidad de este grupo de población es más alta que la general, y en ello tiene mucho que ver esa obesidad junto con otros factores añadidos, como la resistencia a la insulina y la hipertrigliceridemia, factores todos ellos que constituyen el llamado síndrome metabólico. En la actualidad, los estudios sobre la obesidad se están multiplicando. Se vive una situación compleja en la que todavía no se reconocen los mecanismos últimos que actúan, aunque se sabe bastante acerca de los complicados mecanismos reguladores del organismo en los que están implicados múltiples agentes (insulina, leptina, neuropéptido Y, agouty related-protein, proopiomelanocortina, cocain and amphetamine related transcript, galanina, ghrelina, endocannabinoides, betaendorfinas, encefalinas y dinorfinas, etc.). En esta revisión se estudia la acción de la enfermedad mental y de su tratamiento farmacológico sobre este intrincado funcionamiento regulador
Obesity is more frequent in patients with schizophrenia than in the general population. The illness itself plays a role in this epidemiological datum (due to alterations in central neurotransmitters related to satiety), enhanced by the action of some antipsychotic drugs (clozapine, olanzapine). Obesity is one of the factors that leads to the higher mortality found in these patients than in the general population, in addition to other factors such as insulin resistance and hypertriglyceridemia. All these factors together constitute metabolic syndrome. Studies on obesity are being published with increasing frequency. Currently, the situation is complex and the mechanisms involved remain unknown, although much is known about the bodys complex regulatory mechanisms, in which multiple agents are involved (insulin, leptin, neuropeptide Y, agouty related-protein, proopiomelanocortin, cocain and amphetamine related transcript, galanin, ghrelin, endocannabinoids, beta-endorphins, enkephalins and dynorphin). The influence of mental illness and its pharmacological treatment on this intricate regulatory function is the subject of the present review