ABSTRACT
Tumors of the small bowel, both benign and malignant, are relatively uncommon and often present a diagnostic challenge as their symptoms are often vague. This review article outlines the incidence, presentation, diagnosis, and management of small bowel tumors.
Subject(s)
Duodenal Neoplasms , Intestine, Small/pathology , Jejunal Neoplasms , Adenocarcinoma/epidemiology , Adenocarcinoma/pathology , Adenoma/diagnosis , Brunner Glands/pathology , Carcinoid Tumor/diagnosis , Duodenal Neoplasms/diagnosis , Duodenal Neoplasms/epidemiology , Duodenal Neoplasms/pathology , Hamartoma Syndrome, Multiple/diagnosis , Humans , Incidence , Jejunal Neoplasms/diagnosis , Jejunal Neoplasms/epidemiology , Jejunal Neoplasms/pathology , Leiomyoma/diagnosis , Leiomyosarcoma/diagnosis , Lipoma/diagnosis , Lymphoma/diagnosis , Lymphoma/pathology , Peutz-Jeghers Syndrome/diagnosisABSTRACT
Poorly differentiated adenocarcinoma with lymphoid stroma occurred in the transverse colon of a 77 year old female. Numerous small lymphocytes and plasma cells were distributed in the tumor stroma. Non-isotopic in situ hybridization study for Epstein-Barr (EBV)-related small nuclear RNA (EBER-1) revealed positive signals in the nuclei of a few lymphocytes in the tumor stroma, while the tumor cell nuclei were not labeled. Immunostaining for latent membrane protein-1 was negative. The significance of detection of the EBV-infected lymphocytes in the colon tumor stroma is discussed.
Subject(s)
Adenocarcinoma/virology , Colonic Neoplasms/virology , Herpesviridae Infections/pathology , Herpesvirus 4, Human/genetics , Herpesvirus 4, Human/isolation & purification , Lymphocytes/virology , Adenocarcinoma/complications , Adenocarcinoma/pathology , Aged , Colonic Neoplasms/complications , Colonic Neoplasms/pathology , Female , Genome, Viral , Herpesviridae Infections/complications , Humans , Immunoenzyme Techniques , In Situ HybridizationABSTRACT
Poorly differentiated small cell neuroendocrine (NE) carcinoma of the colon and rectum is a rare primary epithelial malignancy at this location. A case of a highly aggressive NE tumor of small cell type, combined with non-invasive well-differentiated papillary adenocarcinoma in villous adenoma is reported. The patient died rapidly with massive and progressive liver metastasis. The tumor cells were argyrophilic and diffusely immunoreactive for neuronspecific enolase and synaptophysin. Ultrastructural analysis disclosed NE-type cored granules in most of the small tumor cells. NE tumors of the colon and rectum are briefly reviewed.
Subject(s)
Carcinoma, Neuroendocrine/pathology , Carcinoma, Small Cell/pathology , Rectal Neoplasms/pathology , Adenocarcinoma, Papillary/pathology , Adenoma, Villous/pathology , Carcinoma, Neuroendocrine/ultrastructure , Humans , Male , Middle Aged , Neoplasms, Multiple Primary/pathologyABSTRACT
Leiomyosarcoma of the extremities is an unusual tumor. Herein we report a unique and what we believe is the first case of a patient in whom there was complete disappearance of such a tumor following regional hyperthermia and chemotherapy.
