1.
Curr Med Chem
; 20(30): 3797-801, 2013.
Article
in English
| MEDLINE
| ID: mdl-23848537
ABSTRACT
A methodology is described for the highly efficient and divergent synthesis of pseudosugars which allows the stereoselective introduction of polar groups at either the α or the ß pseudoanomeric positions. Using this method, a series of 3-deoxycarbasugar analogues of mannose bearing a pyridyl group are rationally designed, prepared and tested for inhibition of Golgi α-mannosidase II.