ABSTRACT
PURPOSE: Coronavirus disease of 2019 (COVID-19) is associated with increased risk of stroke and intracranial hemorrhage. This first report of fulminant panvascular arteriovenous thrombosis with subarachnoid hemorrhage (SAH) in a post-COVID-19 infection is attributed to extensive arteriovenous inflammation leading to arterial rupture following vasculitis. CASE REPORT: We report a rare case of extensive extra- and intra-cranial cerebral arteriovenous thrombosis following COVID-19 infection, presenting as fatal non-aneurysmal subarachnoid hemorrhage. The clinical course, biochemical and radiological evaluation is discussed. The other possible etiological differentials which were analysed and ruled out during case management are also detailed. CONCLUSION: A high degree of suspicion for COVID-19 induced coagulopathy leading to extensive non- aneurysmal, non-hemispheric SAH and malignant intracranial hypertension should be entertained. Our experience and previous reports on non-aneurysmal SAH in such patients show a poor prognosis.
Subject(s)
COVID-19 , Intracranial Aneurysm , Intracranial Hypertension , Intracranial Thrombosis , Stroke , Subarachnoid Hemorrhage , Humans , Subarachnoid Hemorrhage/complications , Subarachnoid Hemorrhage/diagnostic imaging , COVID-19/complications , Intracranial Thrombosis/etiology , Intracranial Thrombosis/complications , Stroke/complications , Intracranial Hypertension/complications , Intracranial Aneurysm/complicationsABSTRACT
Introduction Primary central nervous system (CNS) involvement of Hodgkin's lymphoma is very uncommon. There are only a few previous reports of Hodgkin's lymphoma of nodular lymphocyte predominant histology involving the CNS concurrently with systemic disease. Case presentation A 12-year-old boy with a history of painless left inguinal swelling and acute diplopia. There was an intensely enhancing lesion in the right midbrain on magnetic resonance imaging. The patient was diagnosed with stage IV Hodgkin's lymphoma of nodular lymphocyte predominance type by routine microscopy and immunohistochemistry of left inguinal lymph node biopsy with computed tomography-assisted staging. It was planned to treat him with six cycles of chemotherapy with intrathecal methotrexate, followed by radiotherapy to the CNS lesions. After two cycles of chemotherapy, the patient entered complete remission of all lesions including the CNS lesion documented by the positron emission tomography scan. Conclusion We are describing the course of this rare presentation of Hodgkin's lymphoma of nodular lymphocyte predominant histology involving the CNS and clinical challenge in its diagnosis and management of this case.
Subject(s)
Brain Stem Neoplasms/diagnosis , Brain Stem Neoplasms/secondary , Hodgkin Disease/pathology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Brain Stem Neoplasms/therapy , Child , Disease Management , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Male , Positron-Emission Tomography , Radiotherapy, Adjuvant , Reed-Sternberg Cells , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
We report a case of fungal retinal vasculitis in a 32 week gestational age, 1200 g premature infant detected during routine screening for retinopathy of prematurity at 78 days of age. The patient subsequently developed sepsis with perinephric abscess but responded rapidly to systemic therapy. Fortuitous detection of retinal vasculitis as the first evidence of a systemic fungal infection in an immunocompetent and asymptomatic infant has not, to our knowledge, been previously reported.
Subject(s)
Abscess/microbiology , Bacteremia/microbiology , Candidiasis/microbiology , Eye Infections, Fungal/microbiology , Kidney Diseases/microbiology , Retinal Vasculitis/microbiology , Abscess/diagnostic imaging , Abscess/drug therapy , Antifungal Agents/therapeutic use , Bacteremia/diagnosis , Bacteremia/drug therapy , Candida albicans/isolation & purification , Candidiasis/diagnosis , Candidiasis/drug therapy , Eye Infections, Fungal/diagnosis , Eye Infections, Fungal/drug therapy , Fluconazole/therapeutic use , Gestational Age , Humans , Infant , Infant, Newborn , Infant, Premature , Infant, Very Low Birth Weight , Infusions, Intravenous , Kidney Diseases/diagnostic imaging , Kidney Diseases/drug therapy , Male , Retinal Vasculitis/diagnosis , Retinal Vasculitis/drug therapy , UltrasonographyABSTRACT
A series of 6-substituted and 5,6-disubstituted 2-(6-methyl-benzofuran-3-ylmethyl)-imidazo[2,1-b][1,3,4]thiadiazoles have been synthesized. The new compounds have been tested for their in vivo analgesic, anti-inflammatory activities. Qualitative SAR studies indicate that the chloro substitution in the imidazole ring and introduction of formyl group at C-5 position of the imidazole ring increased the anti-inflammatory and analgesic activity. All the newly synthesized compounds have been characterized by spectral data and ORTEP diagram of one of the intermediates 6-(4-chlorophenyl)-2-(6-methyl-benzofuran-3-ylmethyl)-5-morpholin-4-ylmethyl imidazo[2,1-b][1,3,4]thiadiazole is reported herein.
