[Changes in pain sensitivity under increased atmospheric pressure]. / Izmenenie bolevoi chuvstvitel'nosti pri povyshennom atmosfernom davlenii.

It has been established that augmentation of air pressure from 0.1 to 1.1 MPa (with 0.1 MPa intervals) was accompanied in rats with the development of progressive analgesia which was measured according to the threshold of vocalization in the test of electrical stimulation of the tail. The highest analgesic response arose at 0.7-1.1 MPa. All the animals might be divided into two groups: group 1-72% of the animals with a 200% increase of the threshold, group 2--animals with such an increase by 15%. The augmentation of the pressure of heliox (79.1% of helium, 20.9% of oxygen) also caused analgesia, but not so strong. In patients pain thresholds to the mechanical nociceptive stimulation also increased by about 43-67% and 95-100% under the influence of increased air pressure of 0.4 and 0.7 MPa, respectively. In group 1 patients (67%) pain threshold increased by 50-100%, in group 2 by 15-25%. Pretreatment with naloxone (1 mg/kg), atropine (1 mg/kg), yohimbine (1 mg/kg), parachloramphetamine (5 mg/kg) and prasosin (1 mg/kg) decreased hyperbaric analgesia in rats by 41-56, 41-56, 17-19, 17-19%, respectively. The role of increased partial pressure of nitrogen in hyperbaric analgesia and possible neurochemical mechanisms of its realization are discussed.

[Changes in certain of the body's biochemical indices during decompressive gas formation of different intensities]. / Izmeneniia nekotorykh biokhimicheskikh pokazatelei organizma pri dekompressionnom gazoobrazovanii razlichnoi intensivnosti.

In cats a short-lasting biochemical effect of the compressed air caused no changes in concentration of sodium, potassium or 17-ketosteroids in blood and urine. Through production of gas bubbles, concentration of potassium and sodium ions in plasma is reduced while their excretion increases. Disturbance of sodium and potassium metabolism in the human body as well as activity of suprarenal cortex depend on intensity of decompressive gas production.

[Dynamics of several indices of the enzyme-hormone status of the body after hypobaria and during decompression sickness]. / Dinamika nekotorykh pokazatelei fermentativno-gormonal'nogo statusa organizma posle giperbarii i pri dekompressionnoi bolezni.

Hormone content and enzyme activity change under the influence of hyperbaria and in decompression disease long before the symptoms of the disease appear. Apart from that, an increase in adrenalin, noradrenalin, 17-oxycorticosteroids, and glucose concentrations, erythrocyte number and hemoglobin, as well as lowering of amylase and catalase activities are the indicative signs for prognostication and diagnosis of the decompression disease.