ABSTRACT
The late results of treatment of operable patients with breast carcinoma are analysed. The frequency of local recurrences and metastases in the subclavicular lymph nodes and distal organs are compared according to the method of operative intervention. It is emphasized that purposeful exposure to radiation makes it possible to achieve similar results in Patey's, Halsted's, and Urban-Holdin's operations. From the functional standpoint, however, conservative radical mastectomy surpasses radical and extended radical mastectomy considerably. All this allows Patey's operation in combination with irradiation to be recommended for wide introduction into therapeutic practice at oncological institutions of the Soviet Union.
Subject(s)
Breast Neoplasms/surgery , Mastectomy, Modified Radical , Adult , Aged , Breast Neoplasms/radiotherapy , Combined Modality Therapy , Humans , Lymphatic Metastasis , Mastectomy, Extended Radical , Mastectomy, Radical , Middle Aged , Neoplasm Metastasis , Radiotherapy DosageABSTRACT
Some methodological problems of the use of intracavitary UHF hyperthermia combined with intracavitary gamma-beam therapy in combined radiation therapy of uterine cancer patients are considered. Indications for the use of this method and radiobiological substantiation of thermoradiotherapy for this group of patients are discussed. The advantages of the proposed method of thermoradiotherapy have been noted on the basis of immediate clinical observations, endoscopic, x-ray and morphometric findings.
Subject(s)
Brachytherapy/methods , Hyperthermia, Induced/methods , Uterine Neoplasms/radiotherapy , Brachytherapy/adverse effects , Brachytherapy/instrumentation , Combined Modality Therapy , Evaluation Studies as Topic , Female , Gamma Rays/adverse effects , Gamma Rays/therapeutic use , Humans , Hyperthermia, Induced/adverse effects , Hyperthermia, Induced/instrumentation , Radiotherapy Dosage , Uterine Cervical Neoplasms/radiotherapyABSTRACT
A total of 93 patients were assigned to receive either radiation treatment alone (group 1) or in combination with local microwave-induced hyperthermia (group 2) prior to mastectomy. The treatment results were compared. Within a two-year follow-up period, all patients of group 2 remained free of relapse, metastases being registered in 2 (6.2%) cases. In group 1, relapse was observed in 1 case, whereas metastasis--in 7 (11.5%). The study failed to establish drug-induced tumor pathomorphosis in 12.5% in group 2 and 73.8% in group 1. The procedure did not interfere with surgery, nor was it followed by an increased postoperative complication rate.
Subject(s)
Breast Neoplasms/therapy , Diathermy , Adult , Aged , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Combined Modality Therapy , Female , Humans , Mastectomy , Middle Aged , Preoperative CareABSTRACT
An ultrastructural study of breast cancer cells from 102 female patients after combined therapy with preoperative radiation therapy was conducted. The ultrastructural method made it possible to supplement results obtained by means of the histological method of assessment of tumor radiation pathomorphosis, and in some cases it was even more informative and permitted a comparative assessment of various methods of preoperative radiation therapy using intensively concentrated and large dose fractionation followed by immediate operation.
Subject(s)
Breast Neoplasms/radiotherapy , Adult , Aged , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Combined Modality Therapy , Female , Humans , Hyperthermia, Induced , Microscopy, Electron , Middle Aged , Preoperative Care , Radiotherapy DosageABSTRACT
The authors described a method of two-stage UHF-hyperthermia combined with single irradiation of the breast prior to operation. At the 1st stage the temperature was 39 degrees C, duration of exposure 30 min directly before irradiation, irradiation at a dose of 13 Gy. The 2nd stage followed 2 h after irradiation, the temperature was 42 degrees C, duration 90 min. The above therapy did not deteriorate the conditions of surgical intervention, nor did it complicate a postoperative course. Local and general reactions were of transient nature. No recurrences were noted after 1 year of follow-up. A study of tumor pathomorphosis showed injuries of I degree in 30.8%, II degree in 46.2%, III degree in 5.6%, in single irradiation in 18, 8.4 and 2.8%, respectively.
