Subject(s)
Amyloidosis/mortality , Kidney Diseases/mortality , Actuarial Analysis , Adult , Age Factors , Amyloidosis/etiology , Disease Susceptibility , Female , Humans , Kidney Diseases/etiology , Male , Prognosis , Sex Factors , Survival Rate , USSR/epidemiologySubject(s)
Amyloidosis/complications , Cardiomyopathies/etiology , Familial Mediterranean Fever/complications , Kidney Diseases/complications , Amyloidosis/diagnosis , Cardiomyopathies/diagnosis , Echocardiography , Electrocardiography , Familial Mediterranean Fever/diagnosis , Female , Heart/diagnostic imaging , Humans , Kidney Diseases/diagnosis , Kidney Failure, Chronic/complications , Kidney Failure, Chronic/diagnosis , Male , Nephrotic Syndrome/complications , Nephrotic Syndrome/diagnosis , Proteinuria/complications , Proteinuria/diagnosis , Radionuclide Imaging , Technetium Tc 99m PyrophosphateSubject(s)
Amyloidosis/drug therapy , Kidney Diseases/drug therapy , Amyloidosis/etiology , Amyloidosis/mortality , Colchicine/therapeutic use , Dimethyl Sulfoxide/therapeutic use , Drug Evaluation , Humans , Kidney Diseases/etiology , Kidney Diseases/mortality , Serum Amyloid A Protein/analysis , Unithiol/therapeutic useSubject(s)
Amyloidosis/drug therapy , Arthritis, Rheumatoid/drug therapy , Colchicine/therapeutic use , Adult , Amyloidosis/etiology , Arthritis, Rheumatoid/complications , Drug Evaluation , Female , Humans , Kidney Diseases/drug therapy , Kidney Diseases/etiology , Male , Middle Aged , Rectal Diseases/drug therapy , Rectal Diseases/etiology , Serum Amyloid A Protein , Spondylitis, Ankylosing/complications , Spondylitis, Ankylosing/drug therapyABSTRACT
The authors studied 34 patients with periodic disease. In its thoracal course the development of pericarditis was proved in 1/3 of the patients.
Subject(s)
Familial Mediterranean Fever/diagnosis , Pericarditis/diagnosis , Adolescent , Adult , Diagnosis, Differential , Echocardiography , Familial Mediterranean Fever/classification , Female , Humans , Male , Pericarditis/classificationSubject(s)
Internal Medicine , Tuberculosis, Pulmonary/diagnosis , Adolescent , Adult , Collagen Diseases/diagnosis , Diagnosis, Differential , Diagnostic Errors , Female , Fever/diagnosis , Humans , MaleABSTRACT
The authors provide the clinico-morphologic evidence for amyloid resorption in patients with periodic disease and amyloidosis under the effect of colchicine.
Subject(s)
Amyloidosis/drug therapy , Colchicine/therapeutic use , Familial Mediterranean Fever/drug therapy , Intestinal Mucosa/pathology , Rectum/pathology , Adolescent , Adult , Amyloidosis/complications , Amyloidosis/pathology , Biopsy , Familial Mediterranean Fever/complications , Familial Mediterranean Fever/pathology , Female , Humans , MaleSubject(s)
Amyloidosis/classification , APUD Cells/metabolism , Aged , Amyloid/metabolism , Amyloidosis/complications , Amyloidosis/diagnosis , Amyloidosis/genetics , Amyloidosis/metabolism , Brain Diseases/etiology , Brain Diseases/metabolism , Cardiovascular Diseases/etiology , Cardiovascular Diseases/metabolism , Diagnosis, Differential , Humans , Male , Myocardium/metabolism , Nervous System Diseases/etiology , Nervous System Diseases/metabolism , Prostatic Diseases/etiology , Prostatic Diseases/metabolismSubject(s)
Amyloid/metabolism , Amyloidosis/classification , Serum Amyloid A Protein/metabolism , Amyloid/analysis , Amyloidosis/etiology , Amyloidosis/metabolism , Animals , Humans , Liver/metabolism , Macrophage Activation , Molecular Weight , Serum Amyloid A Protein/analysis , Serum Amyloid P-Component/metabolismABSTRACT
The findings at 1625 autopsies performed by the authors in 45-99-year-olds and literature data have been analysed in relation to clinical and morphological manifestations of senile cardiac amyloidosis (SCA). It occurred in 2.4% of autopsies and accounted for about a half of senile amyloidosis cases recorded by the authors. IAA and SSA are two separate forms of SCA heterogeneous group in which IAA has incidence rate 3 times that of SSA. IAA is a local SCA form, SSA--systemic form (though isolated ventricular affections are possible). The mean age and sex-specific incidence rate differed: 72.3 and 78.2 years for IAA and SSA, respectively; for women IAA incidence is 3.5 times and SSA 2 times that for males. SCA forms presented various amyloidosis degrees, location, spread, as well as amyloid proteins specificity detectable by relevant direct and indirect methods. Differences in clinico-morphological appearance and death causes for IAA and SSA contributed to differential diagnosis between these forms as well as between SSA and PA.
Subject(s)
Amyloidosis/pathology , Cardiomyopathies/pathology , Aged , Aged, 80 and over , Amyloid/metabolism , Amyloidosis/diagnosis , Cardiomyopathies/diagnosis , Diagnosis, Differential , Female , Heart Atria/metabolism , Heart Atria/pathology , Humans , Lung/pathology , Male , Middle Aged , Myocardium/metabolism , Myocardium/pathology , Organ SizeABSTRACT
Acetylation phenotype distribution (activity of N-acetyltransferase enzyme) was studied in 29 patients with periodical disease (PD), 73 healthy persons (Armenians), and 20 patients (also Armenians) suffering from epithelial coccygeal cysts. The results obtained indicated the prevalence of slow acetylation phenotype (67%) in the entire Armenian population. PD was characterized by slow acetylation type (28 of 29 patients had slow acetylation with a high frequency of very slow inactivators). The other hereditary pathology, also specific for Armenians (epithelial coccygeal cysts), was characterized by another type of acetylation--a rapid one. The role of slow acetylation as a genetic marker of PD was discussed.
Subject(s)
Acetyltransferases/metabolism , Familial Mediterranean Fever/genetics , Acetylation , Armenia , Ethnicity , Familial Mediterranean Fever/metabolism , Genetic Markers , Humans , PhenotypeSubject(s)
Heart Neoplasms , Mesothelioma , Pericardium , Adult , Female , Humans , Male , Middle AgedABSTRACT
The paper is concerned with an analysis of a course of periodic disease (PD) without and with amyloidosis using also a method of the determination of survival rates in 437 patients followed up for 20 yrs. A course of PD without amyloidosis was benign and did not affect the patients' survival. In the development of amyloidosis the prognosis was unfavorable and determined by a degree of generalization of amyloidosis.
Subject(s)
Amyloidosis/complications , Familial Mediterranean Fever/complications , Adolescent , Adult , Age Factors , Child , Familial Mediterranean Fever/mortality , Female , Follow-Up Studies , Humans , Male , Middle Aged , PrognosisABSTRACT
The paper is concerned with the results of a study of the phagocytic activity of mouse peritoneal macrophages during induction of casein amyloidosis and neutrophils of patients with hereditary amyloidosis and amyloidosis caused by colchicine. The authors discuss the role of phagocytosis in amyloidogenesis.
Subject(s)
Amyloidosis/physiopathology , Phagocytosis , Amyloid/metabolism , Amyloidosis/chemically induced , Amyloidosis/genetics , Animals , Macrophages/physiology , Mice , Mice, Inbred BALB C , Neutrophils/physiologyABSTRACT
The incidence of arterial hypertension (AH) in patients with renal amyloidosis varied with its stage. Thus, AH was encountered in 13% of cases with renal amyloidosis at the proteinuric stage, 15% of those at the nephrotic stage, and 53% of those at the azotemic stage. One determinant of AH at the first two of these stages appears to have been damage to the antihypertensive system of the renal medulla, while the increased rate of AH at the azotemic stage was found to be associated with sodium retention in the body. AH in renal amyloidosis is an unfavorable prognostic factor, for it is conducive to amyloid shrinkage of the kidneys and to chronic renal failure.