ABSTRACT
Inflammation developed after sewing of silk ligature into the rat and rabbit gingiva (parodonitis) was accompanied by increase in lysozyme content in gingiva tissue and in blood serum. Exogenous egg lysozyme, administered into normal animal gingiva tissue by means of ultrasound treatment (880 kHz, impulse regimen, 0.2 w/cm2), penetrated through the epithelial mucosal membrane layer, but did not accumulate in the membrane. However, lysozyme administered into the inflammation-injured gingiva tissue by ultrasound was accumulated in the tissue and arrested the inflammation and restored the impaired parodontium within shorter periods.
Subject(s)
Gingiva/enzymology , Muramidase/metabolism , Periodontitis/enzymology , Animals , Gingivitis/enzymology , Muramidase/blood , Rabbits , RatsABSTRACT
Periodontitis was simulated in rabbits and rats by suturing a ligature to the gingiva. A follow-up of periodontitis development has revealed the characteristic local (edema, formation of pouches, teeth mobility) and systemic (leukocytosis, moderate hypercalcemia, elevated blood alkaline phosphatase activity, increased blood and gingival lysozyme levels) reactions.
Subject(s)
Periodontitis/etiology , Animals , Disease Models, Animal , Gingiva/pathology , Gingival Pocket/blood , Gingival Pocket/etiology , Gingival Pocket/pathology , Periodontitis/blood , Periodontitis/pathology , Rabbits , Rats , Time FactorsABSTRACT
The study was conducted on 27 Californian breed rabbits and 55 albino mongrel rats. Periodontitis was reproduced in the animals by the ligature method, with the development of clinico-radiological signs characteristic of the disease and similar to those in humans. Correcting therapy of experimental periodontitis by means of lysozymy ultraphonophoresis contributed to the arrest of inflammation in the periodontal tissues, restoration of the calcium content and alkaline phosphatase activity in the blood serum of the animals, and increase of local and general unspecific resistance of the organism.
