ABSTRACT
The content of serum IgG, IgM and IgG was studied in rabbits at varying times of oral sensitization of animals before and after administration of the resolving dose of food protein. The content of IgG was found to be reduced on the 19th-21st day of sensitization. Meanwhile the content of IgA increased on the 24th day of oral sensitization. Administration of the resolving dose of protein on the 19th day of sensitization was followed by the reduction of IgG content. A reverse correlation was revealed between the changes in the content of IgG and the degree of food anaphylaxis in rabbits.
Subject(s)
Anaphylaxis/blood , Food Hypersensitivity/blood , Immunoglobulins/analysis , Animals , Immunoglobulin E/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , RabbitsABSTRACT
The dogs fed protein deficient diet (0.7 g/kg body weight) demonstrated reduced functional activity of T lymphocytes. Particularly, this diet exerted an adverse effect on adequacy of the proliferative response of mononuclear cells in culture in vitro as well as on cytotoxicity of lymphocytes with respect to target cells.
Subject(s)
Dietary Proteins/administration & dosage , Hypersensitivity, Delayed/immunology , T-Lymphocytes/immunology , Animals , Cytotoxicity, Immunologic , Dogs , Freund's Adjuvant/administration & dosage , Immunity, Cellular , Immunization , Lymphocyte Activation , Protein Deficiency/immunologyABSTRACT
The state of an elevated delayed sensitivity was produced in dogs through intramuscular introduction of the human blood serum. Later on lymphocytes were isolated from the peripheral blood of the animals which were then tested by using a blast-transformation reaction and with reference to the lymphocite cytotoxicity. The ration containing an excess amount of protein was found to lower the activity of the lymphoid sensitized cells in the delayed type allergy during the said reactions.
