[The anti-arrhythmia properties of thymogen]. / Antiaritmicheskie svoistva timogena.

The antiarrhythmic and antifibrillary effects of thymogen were determined by using 6 models of arrhythmias induced by aconitine, calcium chloride, strophanthin, low-sodium, reperfusion, and epinephrine. The dose-response curve was examined. The mechanism of thymogen's action was also studied.

[The effect of a number of pharmacological preparations on Na-H metabolic activity and on the passive permeability for protons of the sarcolemma of the isolated heart]. / Vliianie riada farmakologicheskikh preparatov na aktivnost' Na--H-obmena i passivnuiu pronitsaemost' sarkolemmy izolirobvannogo serdtsa dlia protonov.

The influence of the local anesthetics hydrocortisone hemisuccinate and peptide drugs (thymogen and dalargin) on Na-H exchange activity and passive proton permeability of the sarcolemma was studied in experiments on isolated rat hearts. It was established that neither local anesthetics or hydrocortisone hemisuccinate, nor peptide drugs affected Na-H exchange activity. Lidocaine (5 mM), procaine (5 mM), hydrocortisone hemisuccinate (500-750 mg/l) inhibited sarcolemmal passive proton permeability by 40-70%. Aetaphone in the micromolar range attenuated the role of these effects in the antiarrhythmic action of local anesthetics and aetaphone.

[The effect of dalargin on the course of experimental cardiac arrhythmias]. / Vliianie dalargina na techenie éksperimental'nykh aritmii serdtsa.

Five models of arrhythmias (aconitine-, calcium chloride- and low-sodium-induced models on rats, coronary artery ligation and reperfusion in dogs) were used to study the antiarrhythmic and antifibrillatory effects. The latters were not inferior to those shown by the well-known antiarrhythmics. The mechanisms of the action of dalargin are discussed in the paper.