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Pediatr Nephrol ; 29(1): 67-74, 2014 Jan.
Article in English | MEDLINE | ID: mdl-23852271

ABSTRACT

BACKGROUND: It has been suggested that C1q and immunoglobulin M (IgM) nephropathy are variants of minimal change nephrotic syndrome (MCNS). Many researchers believe that these two conditions signify a worse prognosis for children with MCNS in comparison with immunofluorescence (IF)-negative MCNS. The aim of our study was to determine the prognostic significance of C1q nephropathy and IgM nephropathy in children with MCNS. METHODS: Fifty-five children with MCNS who had been biopsied over the course of 24 years at our institution were retrospectively categorized into three groups on the basis of IF microscopy findings: IF-negative MCNS (29/55 patients), MCNS with IgM nephropathy (19/55 patients), and MCNS with C1q nephropathy (7/55 patients). Clinical characteristics at disease presentation, clinical course, and renal outcome were compared between groups during the median follow-up period of 16.9 years (minimum 1.0, maximum 31.1 years). RESULTS: No statistically significant differences in clinical characteristics at disease presentation, clinical course, and renal outcome were found. Children with IgM nephropathy, C1q nephropathy, and IF-negative MCNS were clinically indistinguishable. CONCLUSIONS: We concluded that C1q or IgM nephropathy variants do not seem to signify a worse prognosis in children with MCNS in comparison with IF-negative MCNS.


Subject(s)
Complement C1q/metabolism , Immunoglobulin M/metabolism , Nephrosis, Lipoid/metabolism , Adolescent , Child , Child, Preschool , Female , Fluorescent Antibody Technique , Humans , Immunosuppressive Agents/therapeutic use , Infant , Male , Nephrosis, Lipoid/drug therapy , Nephrosis, Lipoid/pathology , Retrospective Studies
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