ABSTRACT
Introduction: Patients with severe allergic asthma (SAA) are at risk of severe exacerbations. Omalizumab is recommended as an add-on treatment for patients with uncontrolled SAA, despite high-dose inhaled corticosteroids and long acting ß2-agonist combination therapy (standard therapy).RELIEF was a prospective, open label, multicenter study conducted to assess the real-life effectiveness of omalizumab co-administered with standard therapy in patients with SAA for 24 months. Methods: A total of 347 patients aged ≥ 6 years with SAA were enrolled, 285 of whom (8 pediatrics and 277 adolescents and adults) completed this 24-month study. Compared with the 12 months prior to baseline, the mean number of exacerbations was reduced in the overall population at any time interval during the study. Proportion of patients with no exacerbations increased to 77.7% at 24 months from 32.6% at 12 months prior to baseline. A reduction in healthcare resource utilization was also observed. The mean number of specialist visits reduced from baseline (5.8 visits) to 2.4 visits at Month 24. Results: The mean asthma control test score was >19 at every time-point during the study. The rate of Global Evaluation of Treatment Effectiveness (GETE) for asthma response significantly increased at Months 18 and 24 (P <0.05) compared to baseline. Pulmonary function remained relatively stable for the overall study population. There were no new or unexpected safety findings in the study. Conclusion: RELIEF study showed that add-on therapy with omalizumab is effective in reducing exacerbations, healthcare utilization, and improving GETE score in patients with SAA uncontrolled by standard therapy.
ABSTRACT
BACKGROUND: Gut-associated lymphoid tissue (GALT) is mainly formed by the gut mucosa and associated lymphatic structures that under normal conditions induces hyporesponsiveness, a phenomenon termed oral tolerance. However, the potential brakeup of oral tolerance could otherwise lead to disorders such as food allergy. OBJECTIVE: The aim of the study is to characterise the histopathological and immunohistochemical modifications in intestinal gut mucosa in an animal model of food allergy. METHODS: New Zealand rabbits were subcutaneously sensitized twice with ovalbumin (OVA), on day 30 after first sensitization, animals were oral challenged with the same antigen. Lymphatic cell population and accessory cells from gut mucosa were studied by conventional histology, histochemistry and immunohistochemistry. RESULTS: An important increase in number of eosinophils were observed in sensitized and challenged group as well as CD25+cells increase in sensitized animals without challenge. CONCLUSIONS: Data obtained demonstrated that subcutaneous sensitization and challenge with OVA induced generation of specific IgE antibodies and an anaphylactic inflammatory response. This pattern induced quantitative modifications in studied cells and structural changes in mucosa like oedema at intestinal villi in sensitized and challenged rabbits in this animal model of food allergy.
Subject(s)
Food Hypersensitivity , Immunoglobulin E , Allergens/immunology , Animals , Disease Models, Animal , Food Hypersensitivity/immunology , Immunoglobulin E/immunology , OvalbuminABSTRACT
Aged population needs competent physicians. This communication studies geriatric medical teaching, intention of first and fourth year students for specializing in Geriatrics and their opinion about its relevance and curricular setting. Curricula from 10 public and 16 private medical schools were analyzed. Students coursing the first (105) and the fourth year (54) completed an ad hoc opinion poll. 98% of the sample never received training in Geriatrics 2% of first year and none of fourth year students revealed intentions in specializing in Geriatrics. 77% of first year and 91% of fourth year students considered Geriatrics as an important specialization whilst 12% and 4% of those students evaluated it as poorly important. 11% and 5% of them did not know what Geriatrics was. 33% of first year and 18% of fourth year students considered Geriatrics as a postgraduate activity whilst 67% and 82%, an undergraduate one (39% and 36% as a particular subject matter and 61% and 64 % included in different ones). The relevance given by medical students to Geriatrics and their interest to be trained on it during their undergraduate stage is shown.
Subject(s)
Curriculum , Education, Medical, Graduate , Geriatrics/education , Aged , Aging , Humans , Schools, MedicalABSTRACT
Los gerontes necesitan médicos competentes en fisiología y patologías del anciano. Objetivo: relevar la enseñanza de Geriatría, intención de los alumnos de 10 y 40 año de especializarse en Geriatría y opinión sobre importancia y momento en que deberían desarrollarse sus contenidos. Se analizaron los currículos de 10 Facultades de Medicina Estatales y 16 Privadas. En Medicina 98% de los alumnos no reciben enseñanza de Geriatría. Se encuestaron 105 alumnos de 10 y 54 de 40 año sobre intención de especializarse en Geriatría, su importancia y si sus contenidos deberían incluirse en postgrado o en grado, como asignatura o incluidos en las distintas asignaturas. En 10 año el 2% optó por Geriatría. Ningún alumno de 40 año se especializará en Geriatría. En 10 año, 77% la consideran importante, 12% poco importante y 11 % no sabe. En 40 año 91% la considera importante, 4% poco importante y 5% no sabe. En 10 año: 33% consideran que debe incluirse en postgrado, 67% en grado, 39% como asignatura y 61 % incluidos en asignaturas. En 40 año: 18 % la ubican en el postgrado y 82% en grado, 36% como asignatura y 64% incluida en asignaturas. Los resultados muestran la alta valoración de los alumnos por la Geriatría y su interés por capacitarse durante el grado.(AU)
Aged population needs competent physicians. This communication studies geriatric medical teaching, intention of first and fourth year students for specializing in Geriatrics and their opinion about its relevance and curricular setting. Curricula from 10 public and 16 private medical schools were analyzed. Students coursing the first (105) and the fourth year (54) completed an ad hoc opinion polI. 98% of the sample never received training in Geriatrics 2% of first year and none of fourth year students revealed intentions in specializing in Geriatrics 77% of first year and 91 % of fourth year students considered Geriatrics as an important specialization whilst 12% and 4 % of those students evaluated it as poorly important. 11 % and 5 % of them did not know what Geriatrics was. 33% of first year and 18% of fourth year students considered Geriatrics as a...(AU)
Subject(s)
Humans , Aged , Geriatrics/education , Education, Medical, Graduate , Curriculum , Schools, Medical , AgingABSTRACT
Los gerontes necesitan médicos competentes en fisiología y patologías del anciano. Objetivo: relevar la enseñanza de Geriatría, intención de los alumnos de 10 y 40 año de especializarse en Geriatría y opinión sobre importancia y momento en que deberían desarrollarse sus contenidos. Se analizaron los currículos de 10 Facultades de Medicina Estatales y 16 Privadas. En Medicina 98% de los alumnos no reciben enseñanza de Geriatría. Se encuestaron 105 alumnos de 10 y 54 de 40 año sobre intención de especializarse en Geriatría, su importancia y si sus contenidos deberían incluirse en postgrado o en grado, como asignatura o incluidos en las distintas asignaturas. En 10 año el 2% optó por Geriatría. Ningún alumno de 40 año se especializará en Geriatría. En 10 año, 77% la consideran importante, 12% poco importante y 11 % no sabe. En 40 año 91% la considera importante, 4% poco importante y 5% no sabe. En 10 año: 33% consideran que debe incluirse en postgrado, 67% en grado, 39% como asignatura y 61 % incluidos en asignaturas. En 40 año: 18 % la ubican en el postgrado y 82% en grado, 36% como asignatura y 64% incluida en asignaturas. Los resultados muestran la alta valoración de los alumnos por la Geriatría y su interés por capacitarse durante el grado.
Aged population needs competent physicians. This communication studies geriatric medical teaching, intention of first and fourth year students for specializing in Geriatrics and their opinion about its relevance and curricular setting. Curricula from 10 public and 16 private medical schools were analyzed. Students coursing the first (105) and the fourth year (54) completed an ad hoc opinion polI. 98% of the sample never received training in Geriatrics 2% of first year and none of fourth year students revealed intentions in specializing in Geriatrics 77% of first year and 91 % of fourth year students considered Geriatrics as an important specialization whilst 12% and 4 % of those students evaluated it as poorly important. 11 % and 5 % of them did not know what Geriatrics was. 33% of first year and 18% of fourth year students considered Geriatrics as a...
Subject(s)
Humans , Aged , Curriculum , Education, Medical, Graduate , Geriatrics/education , Aging , Schools, MedicalABSTRACT
UNLABELLED: MEMORY: ability to record, file, classify and later recover of information., essential in processing information and learning, in analogy with a computer. FORGETFULNESS: failure to transfer information from short term memory to long term memory or to recover information from the latter. AIM: to study forgetfulness in contents of Histology in students one and half year after regular course. To evaluate level of re-utilization of contents in second and third year courses. Students with high performance in 2002 (n=26) were evaluated with 20 cytology and histology questions and 20 questions related to organs. 20 multiple choice and 20 brief filled answers were used, expressing the level of usefulness of the contents in Physiology and Physicochemistry, and in the first quarter of Pathology, Microbiology and Pharmacology. The performance of 2002 course was compared with the current test, results of cytology and histology questions versus organs ones and multiple choice answers versus brief filled answers. The loss was in the order of 50% in the recovery of contents (37.07 +/- 1,76 = 92,6% vs. 18,52 +/- 4,33 = 46,3%) without difference between cytology and histology versus organs neither among multiple choice answers versus brief filled answers. The highest usefulness in the contents refers to Pathology (69%) and Physiology (50%) and the lesser to PhysicoChemistry.(7%) We estimate that forgetfulness in our students would have been even higher without the employment of active techniques of learning.
Subject(s)
Curriculum , Histology/education , Mental Recall , Students, Medical/psychology , Humans , Time FactorsABSTRACT
Rabbit MAC-1 receptor, homologue to human CD11b is present in macrophages. The aim of the study was to determine quantitative and distributive modifications of CD11b-positive cells that participate in immune response at rectal mucosa, in an animal model of mucosal immunity. New Zealand rabbits were divided into three groups. G1: control; G2: ovalbumin (OVA) sensitized; G3: OVA-senstitized and rectal challenged. Animals were subcutaneously sensitized twice with 70 microg OVA and 30 ml aluminium hydroxide in 2 ml saline solution. Rectal challenge was developed with a solution of 50 mg OVA in 5 ml saline solution. Sensitized groups (G2 and G3) showed a positive PCA (Passive Cutaneous Anaphylaxis) at 1/160 fold dilutions. In G3 we observed a patchy mucosal edema, lymphangiectasis and eosinophil leucocyte infiltration. Cells were counted as the number of cells per high power field. G1: 9.64 (SE 0.22); G2: 18.10 (SE 0.09) and G3: 23.60 (SE 0.29). (G2 vs G1 p < 0.001; G3 vs G1 p < 0.001; G3 vs G2 p < 0.001). We conclude that there is a close relationship between the food antigen OVA penetration (after challenge) and the increase of CD11b positive cells in rectal mucosa. This fact could be due to the cellular influx to the inflammatory site by the action of chemotactic factors released after challenge.
Subject(s)
CD11b Antigen/immunology , Food Hypersensitivity/immunology , Macrophage-1 Antigen/immunology , Ovalbumin/immunology , Rectum/cytology , Animals , Cell Count , Disease Models, Animal , Immunity, Mucosal/immunology , Immunization , Immunoglobulin E/immunology , Male , Mucous Membrane/cytology , Mucous Membrane/immunology , Rabbits , Rectum/immunologyABSTRACT
El receptor MAC-1 de conejo, homólogo al CD11b humano, es una proteína presente en los macrófagos. El objetivo del presente trabajo es establecer las modificaciones cuantitativas y distributivas de células CD11bpositivas participantes en la respuesta inmune a nivel de la mucosa rectal, en un modelo animal de inmunidad mucosa. Se estudiaron conejos neocelandeses divididos en tres grupos: G1:control, G2:sensibilizado con ovoalbúmina (OVA) y G3:sensibilizado y desafiado por vía rectal con OVA. Los conejos de los grupos 2 y 3 fueron sensibilizados por vía subcutánea en dos oportunidades, con 2 ml de una suspensión de 70 µg de OVA en 30 mg de hidróxido de aluminio/ml. El desafío rectal se realizó con una solución de 50 mg OVA en 5 ml de solución salina. La prueba de anafilaxia cutánea pasiva (PCA) fue positiva en G2 y G3 a una dilución de 1/160. En el grupo sensibilizado y desafiado se observó edema mucoso parcheado, imágenes de linfangiectasias e infiltración de eosinófilos. Las células se contaron como número de células por campo de mayor ...
Subject(s)
Animals , Male , Rabbits , /immunology , Food Hypersensitivity/immunology , Macrophage-1 Antigen/immunology , Ovalbumin/immunology , Rectum/cytology , Cell Count , Disease Models, Animal , Immunization , Immunoglobulin E/immunology , Mucous Membrane/cytology , Mucous Membrane/immunology , Rectum/immunologyABSTRACT
El receptor MAC-1 de conejo, homólogo al CD11b humano, es una proteína presente en los macrófagos. El objetivo del presente trabajo es establecer las modificaciones cuantitativas y distributivas de células CD11bpositivas participantes en la respuesta inmune a nivel de la mucosa rectal, en un modelo animal de inmunidad mucosa. Se estudiaron conejos neocelandeses divididos en tres grupos: G1:control, G2:sensibilizado con ovoalbúmina (OVA) y G3:sensibilizado y desafiado por vía rectal con OVA. Los conejos de los grupos 2 y 3 fueron sensibilizados por vía subcutánea en dos oportunidades, con 2 ml de una suspensión de 70 Ag de OVA en 30 mg de hidróxido de aluminio/ml. El desafío rectal se realizó con una solución de 50 mg OVA en 5 ml de solución salina. La prueba de anafilaxia cutánea pasiva (PCA) fue positiva en G2 y G3 a una dilución de 1/160. En el grupo sensibilizado y desafiado se observó edema mucoso parcheado, imágenes de linfangiectasias e infiltración de eosinófilos. Las células se contaron como número de células por campo de mayor ...(AU)
Subject(s)
Animals , Male , Rabbits , CD11b Antigen/immunology , Rectum/cytology , Food Hypersensitivity/immunology , Ovalbumin/immunology , Macrophage-1 Antigen/immunology , Rectum/immunology , Mucous Membrane/cytology , Mucous Membrane/immunology , Immunoglobulin E/immunology , Disease Models, Animal , Cell Count , ImmunizationABSTRACT
Rabbit MAC-1 receptor, homologue to human CD11b is present in macrophages. The aim of the study was to determine quantitative and distributive modifications of CD11b-positive cells that participate in immune response at rectal mucosa, in an animal model of mucosal immunity. New Zealand rabbits were divided into three groups. G1: control; G2: ovalbumin (OVA) sensitized; G3: OVA-senstitized and rectal challenged. Animals were subcutaneously sensitized twice with 70 microg OVA and 30 ml aluminium hydroxide in 2 ml saline solution. Rectal challenge was developed with a solution of 50 mg OVA in 5 ml saline solution. Sensitized groups (G2 and G3) showed a positive PCA (Passive Cutaneous Anaphylaxis) at 1/160 fold dilutions. In G3 we observed a patchy mucosal edema, lymphangiectasis and eosinophil leucocyte infiltration. Cells were counted as the number of cells per high power field. G1: 9.64 (SE 0.22); G2: 18.10 (SE 0.09) and G3: 23.60 (SE 0.29). (G2 vs G1 p < 0.001; G3 vs G1 p < 0.001; G3 vs G2 p < 0.001). We conclude that there is a close relationship between the food antigen OVA penetration (after challenge) and the increase of CD11b positive cells in rectal mucosa. This fact could be due to the cellular influx to the inflammatory site by the action of chemotactic factors released after challenge.
ABSTRACT
MEMORY: ability to record, file, classify and later recover of information., essential in processing information and learning, in analogy with a computer. FORGETFULNESS: failure to transfer information from short term memory to long term memory or to recover information from the latter. AIM: to study forgetfulness in contents of Histology in students one and half year after regular course. To evaluate level of re-utilization of contents in second and third year courses. Students with high performance in 2002 (n=26) were evaluated with 20 cytology and histology questions and 20 questions related to organs. 20 multiple choice and 20 brief filled answers were used, expressing the level of usefulness of the contents in Physiology and Physicochemistry, and in the first quarter of Pathology, Microbiology and Pharmacology. The performance of 2002 course was compared with the current test, results of cytology and histology questions versus organs ones and multiple choice answers versus brief filled answers. The loss was in the order of 50
in the recovery of contents (37.07 +/- 1,76 = 92,6
vs. 18,52 +/- 4,33 = 46,3
) without difference between cytology and histology versus organs neither among multiple choice answers versus brief filled answers. The highest usefulness in the contents refers to Pathology (69
) and Physiology (50
) and the lesser to PhysicoChemistry.(7
) We estimate that forgetfulness in our students would have been even higher without the employment of active techniques of learning.
ABSTRACT
Antigenic macromolecules present in food can induce inflammatory allergic reaction in sensitized persons. The aim of the present work is the development of an animal model to detect food antigens based on hypersensitivity reaction after food ingestion. New Zealand rabbits were divided in 5 groups. Group 1 (GI): control. G2: Ovalbumin (OVA) sensitized. G3: sensitized and orally challenged with OVA. G4: OVA sensitized and phosphate buffer solution challenged (PBS). G5: sensitized and challenged with OVA. Samples from cecum were stained with Alcian Blue pH < 1 for mast cells and with silver method for enteroendocrine cells (EEC). Other samples were immunostained with anti CD5 and CD25 monoclonal antibodies. Specific IgE levels were detected by PCA. Histopathology of G5 showed patchy edema, lymphangiectasia and eosinophilic infiltration. Results were expressed as cells per HPF (high power field); Mast cells in G1: 1.33; G2: 12.80 and G5: 10.20. Enteroendocrine cells in surface epithelium: G1: 1.6; G2: 6.0; G5: 4.2 and in deep epithelium: G1: 3.0; G2: 12.0 and G5: 7.3. Lymphocytes CD5+ in G1: 24.21: G2: 22.12 and G5: 23.97 and CD25+ in G1: 12.10: G2: 14.30 and G5: 21.68. Group 3 were similar to G1 and G4 to G2. We observed: mast cells increased in number probably due to OVA induced response. EEC showed an increase in sensitized animals because of higher expression of cytoplasmatic granules or differentiation from stem cells. Decrease in EEC number in challenged groups was likely to be based on vesicles release. Total T cells showed no significant differences among groups. CD 25+ cells were higher in sensitized and challenged animals. We concluded that rabbit model of sensitization and oral challenge is valid to study ingested food antigens and potential digestive pathologic reactions.
Subject(s)
Antigens/isolation & purification , Disease Models, Animal , Food Hypersensitivity/immunology , Animals , Antibodies, Monoclonal , Cecum/immunology , Cell Count , Enteroendocrine Cells , Immunoglobulin E/analysis , Mast Cells , Rabbits , T-LymphocytesABSTRACT
Antigenic macromolecules present in food can induce inflammatory allergic reaction in sensitized persons. The aim of the present work is the development of an animal model to detect food antigens based on hypersensitivity reaction after food ingestion. New Zealand rabbits were divided in 5 groups. Group 1 (GI): control. G2: Ovalbumin (OVA) sensitized. G3: sensitized and orally challenged with OVA. G4: OVA sensitized and phosphate buffer solution challenged (PBS). G5: sensitized and challenged with OVA. Samples from cecum were stained with Alcian Blue pH < 1 for mast cells and with silver method for enteroendocrine cells (EEC). Other samples were immunostained with anti CD5 and CD25 monoclonal antibodies. Specific IgE levels were detected by PCA. Histopathology of G5 showed patchy edema, lymphangiectasia and eosinophilic infiltration. Results were expressed as cells per HPF (high power field); Mast cells in G1: 1.33; G2: 12.80 and G5: 10.20. Enteroendocrine cells in surface epithelium: G1: 1.6; G2: 6.0; G5: 4.2 and in deep epithelium: G1: 3.0; G2: 12.0 and G5: 7.3. Lymphocytes CD5+ in G1: 24.21: G2: 22.12 and G5: 23.97 and CD25+ in G1: 12.10: G2: 14.30 and G5: 21.68. Group 3 were similar to G1 and G4 to G2. We observed: mast cells increased in number probably due to OVA induced response. EEC showed an increase in sensitized animals because of higher expression of cytoplasmatic granules or differentiation from stem cells. Decrease in EEC number in challenged groups was likely to be based on vesicles release. Total T cells showed no significant differences among groups. CD 25+ cells were higher in sensitized and challenged animals. We concluded that rabbit model of sensitization and oral challenge is valid to study ingested food antigens and potential digestive pathologic reactions.
Subject(s)
Animals , Rabbits , Antigens/isolation & purification , Disease Models, Animal , Food Hypersensitivity , Antibodies, Monoclonal , Cecum , Cell Count , Enteroendocrine Cells , Immunoglobulin E , Mast Cells , T-LymphocytesSubject(s)
Humans , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/therapeutic use , Administration, Inhalation , Beclomethasone/pharmacology , Beclomethasone/administration & dosage , Steroids, Fluorinated/pharmacology , Steroids, Fluorinated/administration & dosage , Budesonide/pharmacology , Budesonide/administration & dosage , Triamcinolone/pharmacology , Triamcinolone/administration & dosage , Receptors, Steroid/drug effects , Glucocorticoids/pharmacology , Glucocorticoids/administration & dosage , Drug EvaluationABSTRACT
Antecedentes: el asma bronquial (AB) es una enfermedad de alta frecuencia de presentación en la ciudad de Rosario. Sin embargo, poco se conoce acerca de su prevalencia dentro de la comunidad aborigen Toba que reside en esta ciudad, producto de migraciones internas realizadas principalmente en los últimos años. Objetivo: estimar la prevalencia de AB en esta comunidad que posee características endogámicas. Material y método: se realizaron 604 encuestas utilizando un cuestionario de "Salud Respiratoria", a personas de la etnia Toba que habitan en un sector de la zona oeste de la ciudad, seleccionando los hogares a encuestar, en forma aleatoria con muestreo sistemático. La muestra fue dividida en 4 grupos etarios: 1-5 años (n = 117); 6-12 años (n = 156); 13-18 años (n = 83) y 19-50 años (n = 248). El 52 por ciento eran de sexo femenino. Resultados: se observan en la siguiente tabla (los datos corresponden a los últimos 12 meses y estan expresados en porcentajes):... El 6,9 por ciento del total de los encuestados refirió antecedentes familiares de atopia y sólo el 5,2 por ciento se encuentra recibiendo tratamiento para el asma. Conclusiones: la prevalencia de AB hallada en la comunidad Toba de la ciudad de Rosario fue inferior a la encontrada por otros autores en los niños y adolescentes de la población general. En el grupo de mayores de 18 años ésta fue superior a la de la comunidad no Toba (AU)
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Adolescent , Adult , Middle Aged , Asthma/epidemiology , Argentina , Oceanians , Indians, South American , Cross-Sectional Studies , Morbidity SurveysABSTRACT
Antecedentes: el asma bronquial (AB) es una enfermedad de alta frecuencia de presentación en la ciudad de Rosario. Sin embargo, poco se conoce acerca de su prevalencia dentro de la comunidad aborigen Toba que reside en esta ciudad, producto de migraciones internas realizadas principalmente en los últimos años. Objetivo: estimar la prevalencia de AB en esta comunidad que posee características endogámicas. Material y método: se realizaron 604 encuestas utilizando un cuestionario de "Salud Respiratoria", a personas de la etnia Toba que habitan en un sector de la zona oeste de la ciudad, seleccionando los hogares a encuestar, en forma aleatoria con muestreo sistemático. La muestra fue dividida en 4 grupos etarios: 1-5 años (n = 117); 6-12 años (n = 156); 13-18 años (n = 83) y 19-50 años (n = 248). El 52 por ciento eran de sexo femenino. Resultados: se observan en la siguiente tabla (los datos corresponden a los últimos 12 meses y estan expresados en porcentajes):... El 6,9 por ciento del total de los encuestados refirió antecedentes familiares de atopia y sólo el 5,2 por ciento se encuentra recibiendo tratamiento para el asma. Conclusiones: la prevalencia de AB hallada en la comunidad Toba de la ciudad de Rosario fue inferior a la encontrada por otros autores en los niños y adolescentes de la población general. En el grupo de mayores de 18 años ésta fue superior a la de la comunidad no Toba
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Adolescent , Adult , Middle Aged , Asthma/epidemiology , Argentina , Cross-Sectional Studies , Indians, South American , Morbidity Surveys , Native Hawaiian or Other Pacific IslanderABSTRACT
Se estudió la prevalencia del Asma Bronquial en la población escolar de la ciudad de Rosario, además de las variaciones entre sexos, edad de comienzo de los síntomas, estacionalidad, frecuencia en la asistencia a salas de emergencia, internaciones, asociación con otras patologías alérgicas, antecedentes familiares, asociación con padres fumadores, y la influencia en el rendimiento escolar y deportivo. El estudio fue realizado mediante el empleo de un cuestionario confeccionado para que respondieran los padres. Fueron encuestados 347 niños de ambos sexos de primero, cuarto y séptimo grado de escuelas de Rosario, con un promedio de edad de 9.5 años, hallándose una prevalencia del asma bronquial del 15.56% para todo el grupo, siendo mayores los valores (48.14%) entre los niños de 6 y 7 años con un promedio leve del sexo masculino (55.55%). La edad más frecuente de comienzo de los síntomas osciló entre los 1 y 4 años (48.14%). El 66.66% de los encuestados asmáticos presentaron historia familiar de alergia, advirtiéndose, además, una importante relación entre niños asmáticos y padres fumadores
Subject(s)
Humans , Male , Female , Asthma/epidemiology , Morbidity Surveys , Argentina , Asthma/complications , Cross-Sectional Studies , UnderachievementABSTRACT
Se estudió la prevalencia del Asma Bronquial en la población escolar de la ciudad de Rosario, además de las variaciones entre sexos, edad de comienzo de los síntomas, estacionalidad, frecuencia en la asistencia a salas de emergencia, internaciones, asociación con otras patologías alérgicas, antecedentes familiares, asociación con padres fumadores, y la influencia en el rendimiento escolar y deportivo. El estudio fue realizado mediante el empleo de un cuestionario confeccionado para que respondieran los padres. Fueron encuestados 347 niños de ambos sexos de primero, cuarto y séptimo grado de escuelas de Rosario, con un promedio de edad de 9.5 años, hallándose una prevalencia del asma bronquial del 15.56% para todo el grupo, siendo mayores los valores (48.14%) entre los niños de 6 y 7 años con un promedio leve del sexo masculino (55.55%). La edad más frecuente de comienzo de los síntomas osciló entre los 1 y 4 años (48.14%). El 66.66% de los encuestados asmáticos presentaron historia familiar de alergia, advirtiéndose, además, una importante relación entre niños asmáticos y padres fumadores
