ABSTRACT
Although bacterial vaginosis is the most common and benign vaginal infection worldwide, some cases of severe acute infections have been described in the literature. We report the case of a 57-year-old French female who developed a life-threatening postoperative peritonitis after a total hysterectomy with adnexectomy in the context of the removal of leiomyosarcoma. The microbiological analysis of the peritoneal fluid identified Gardnerella vaginalis and Atobopium vaginae. The final diagnosis was a septic shock induced by an early onset peritonitis caused by Gardnerella vaginalis and Atobopium vaginae. The normal flora of the genital area could lead to a serious life threatening postoperative infection and should always be in the differential diagnosis.
ABSTRACT
BACKGROUND: Mutations in the angiogenin gene, ANG, have been associated recently with familial and sporadic forms of amyotrophic lateral sclerosis (ALS). However, the cellular and molecular mechanisms that link ANG, a multidomain protein, to ALS are still unknown. OBJECTIVE: To assess the frequency of ANG gene mutations in 855 French patients with sporadic ALS. DESIGN: We analyzed by direct sequencing the full coding region of the ANG gene in a cohort of French patients with sporadic ALS. The clinical characteristics of patients carrying ANG mutations are detailed. SETTING: French ALS Study Group. Patients A total of 855 patients with sporadic ALS. MAIN OUTCOME MEASURES: Results of genetic analyses. RESULTS: We observed a previously identified mutation (pI46V) in 2 patients with ALS without a known family link and found a novel mutation (pR121H) in 1 patient who developed ALS with rapid progression. We did not observe an association between patients with ALS and the rs11701 polymorphism, as previously reported in certain ALS populations of other ethnic origins. CONCLUSION: Overall, our findings support the implication of ANG gene mutations as a rare but widespread cause of ALS.
