ABSTRACT
The results of cytogenetic and FISH analysis performed in 26 cases of Dupuytren contracture are reported. Clonal or sporadic chromosome changes were found in 18 cases (69%). Clonal changes consisted of: +2, +16, -10, -Y, add(1)(p23), del(2)(q21), t(3;16)(p21;q24), add (3)(p24), del(18)(q21), t(Y;14)(p12;q24), +mar. The results differ from those obtained in normal palmar fascia used as control, in which -Y and +Y were the only clonal changes found in 2 of 11 analyzed cases (18%). No clonal trisomy 8 was found. FISH analysis performed in 11 cases (centromeric probe specific for chromosome 8) failed to show the presence of a cell population with +8. Clonal and sporadic structural changes were different from case to case and no clustering breakpoint was observed. The significance of the chromosome instability leading to clonal and sporadic chromosome changes not specific to Dupuytren contracture are discussed.
Subject(s)
Chromosomes, Human, Pair 8 , Dupuytren Contracture/genetics , Trisomy , Aged , Aged, 80 and over , Centromere/genetics , Humans , Interphase/genetics , Karyotyping , Male , Middle Aged , Y ChromosomeABSTRACT
From 1987 to 1994, 24 patients underwent resection for pancreatic cancer; they represented 24% of all patients observed in that period. Surgical procedures were a pancreatoduodenectomy (PD) in 20 cases, a distal pancreatectomy in 4 cases, a palliative intervention in 61 cases, an exploratory laparotomy in 13 cases and a video laparoscopy in 2 cases. Adjuvant treatments were given in addition to resection in 20 patients. In the 20 patients undergoing PD, mortality was 20% and morbidity 20%. There was no mortality and no morbidity in distal pancreatectomy. The 1-year survival in pancreatoduodenectomy was 50% and 0% for distal pancreatectomy. Pancreatic resection, radical and palliative, whenever technically possible, represents the treatment of choice for pancreatic cancer.
Subject(s)
Pancreatic Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Female , Humans , Laparoscopy , Male , Middle Aged , Palliative Care , Pancreatectomy , Pancreatic Neoplasms/mortality , Pancreaticoduodenectomy , Quality of Life , Retrospective StudiesSubject(s)
Cholangiography/methods , Cholestasis/diagnostic imaging , Aged , Cholangiography/adverse effects , Female , Humans , Male , Middle AgedSubject(s)
Breast Diseases/pathology , Phlebitis/pathology , Adult , Breast/blood supply , Female , Humans , MammographySubject(s)
Cholestasis/therapy , Drainage/methods , Aged , Catheterization , Drainage/instrumentation , Female , Humans , MaleABSTRACT
3450 women were examined in the Breast Cancer Clinic of the 2nd General Surgery Division of the Mantova Hospitals between November 1979 and November 1982. Cancer was found in 105 cases (3.04%). The variety of conditions observed and the tests used to discover whether they were benign or malignant are described.
Subject(s)
Breast Neoplasms/pathology , Breast/pathology , Adult , Aged , Female , Fibrocystic Breast Disease/pathology , Humans , Mastitis/pathology , Middle Aged , Outpatient Clinics, Hospital , PregnancyABSTRACT
The correction of the dumping syndrome is based on three surgical techniques: narrowing of the gastrojejunal for gastroduodenal) anastomosis, interposition of an intestinal loop between the gastric stump and the duodenum, or conversion of Billroth II to Billroth I. The authors report the results obtained in a series of 22 cases.
