Potential of auxiliary strobe lights on train locomotives to improve level crossing safety.

Inattentiveness of road users on approach to passive railway crossings represents a major threat to level crossing safety. An auxiliary strobe light system installed on trains in addition to existing headlights may help address this issue by providing an ergonomic way of attracting human attention to the level crossing and to the train. The objective of this paper was to investigate the ergonomics and safety potential of auxiliary strobe light systems. A system was implemented on a real railway vehicle and in the virtual environment of a driving simulator. Acceptance of the system, including its usefulness and perceived benefits and drawbacks, as well as its objective effectiveness, were evaluated using questionnaires, behavioural measures, and eye tracking. The safety potential of the system was evaluated with respect to fatal level crossing accidents. The auxiliary strobe lights were preferred over normal lights and were rated as useful, reducing driving speeds, increasing visual scanning at level crossings, and thus aiding detection of a train. The system has the potential to prevent 6-30% of level crossing accidents in Europe. The results suggest that it might be worthwhile to test auxiliary strobe lights in a larger scale real-world experiment. Especially on railway lines with a high number of passive level crossings, this system can be expected to increase safety by supporting timely detection by road users and preventing accidents caused by inattentiveness.

Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats.

Treatment of brain cancer, glioma, can cause cognitive impairment as a side-effect, possibly because it disrupts the integrity of the hippocampus, a structure vital for normal memory. Radiotherapy is commonly used to treat glioma, but the effects of irradiation on the brain are still poorly understood, and other biological effects have not been extensively studied. Here, we exposed healthy adult male rats to moderate-dose irradiation of the head. We found no effect of irradiation on systemic inflammation, weight gain or gut microbiota diversity, although it increased the abundance of Bacteroidaceae family, namely Bacteroides genus in the gut microbiota. Irradiation had no effect on long-term potentiation in the CA3-CA1 synapse or endogenous hippocampal electrophysiology, but it did reduce adult hippocampal neurogenesis and impaired short-term spatial recognition memory. However, no overall cognitive impairment was observed. To summarize, our results suggest that in adult male rats head irradiation does not compromise health or cognition overall even though the number of new, adult-born hippocampal neurons is decreased. Thus, the sole effects of head irradiation on the body, brain and cognition might be less harmful than previously thought, and the cognitive decline experienced by cancer patients might originate from physiological and mental effects of the disease itself. Therefore, to increase the translational value of animal studies, the effects of irradiation should be studied together with cancer, in older animals, using varying irradiation protocols and doses.