Two Infants with Presumed Congenital Zika Syndrome, Brownsville, Texas, USA, 2016-2017.

Since 2007, Zika virus has spread through the Pacific Islands and the Americas. Beginning in 2016, women in Brownsville, Texas, USA, were identified as possibly being exposed to Zika virus during pregnancy. We identified 18 pregnant women during 2016-2017 who had supportive serologic or molecular test results indicating Zika virus or flavivirus infection. Two infants were evaluated for congenital Zika syndrome after identification of prenatal microcephaly. Despite standard of care testing of mothers and neonates, comparative results were unreliable for mothers and infants, which highlights the need for clinical and epidemiologic evidence for an accurate diagnosis. A high index of suspicion for congenital Zika syndrome for at-risk populations is useful because of current limitations of testing.

Is cerclage height associated with the incidence of preterm birth in women with a history-indicated cerclage?

This study was performed to determine if cerclage height is associated with spontaneous preterm birth in patients with a history-indicated cerclage. We performed a retrospective cohort study of women with a history-indicated cerclage. Functional cervical length and the cerclage height (distance from cerclage to the external cervical os) were obtained. The cohort was grouped into thirds, based on cerclage height percentile. Our primary outcome was spontaneous preterm birth <35 weeks. There were 21 women in group 1 (cerclage height <10 mm), 53 in group 2 (cerclage height 10 to 19 mm), and 31 in group 3 (cerclage height ≥20 mm). The rates of spontaneous preterm birth <35 weeks were similar between each group: 24, 17, and 10%, respectively ( P = 0.38). Cerclage height is not associated with a reduction in spontaneous preterm birth for women with a history-indicated cerclage. The association between longer cerclage height and decrease in preterm birth was nonsignificant possibly due to the small sample size.

Interval to spontaneous delivery after elective removal of cerclage.

OBJECTIVE: The purpose of this study was to estimate the time interval between elective cerclage removal and spontaneous delivery. METHODS: Singleton pregnancies with McDonald cerclage were evaluated for the interval between elective cerclage removal (36-37 weeks) and spontaneous delivery. We also compared spontaneous delivery within 48 hours after cerclage removal between women with ultrasound-indicated vs history-indicated cerclage. RESULTS: We identified 141 women with elective cerclage removal. The mean interval between removal and delivery was 14 days. Only 11% of women delivered within 48 hours. Women with ultrasound-indicated cerclage were more likely to deliver within 48 hours, compared with women with history-indicated cerclage (odds ratio, 5.14; 95% confidence interval, 1.10-24.05). CONCLUSION: The mean interval between elective cerclage removal and spontaneous delivery is 14 days. Women with cerclage who achieved 36-37 weeks should be counseled that their chance of spontaneous delivery within 48 hours after elective cerclage removal is only 11%.

Factors predictive for failure to perform postpartum tubal ligations following vaginal delivery.

OBJECTIVE: To identify patients requesting postpartum sterilization and compare those who underwent the procedure with those who did not. STUDY DESIGN: A retrospective study of requested postpartum tubal ligations was completed. Demographics and clinical characteristics were analyzed. We analyzed whether the failure to obtain postpartum sterilization resulted in an interval laparoscopic tubal ligation or future pregnancy. RESULTS: A total of 135 women requested sterilization, but only 56% received the desired procedure. Time of delivery (OR 2.23, CI 1.08-4.58), body mass index (OR 2.38, CI 1.10-5.16) and gravidity (OR 0.80, CI 0.65-0.97) were significant variables that were different between the 2 groups. Of the women who left the hospital postpartum without a sterilization procedure, 44% received an interval laparoscopic tubal ligation and 18% later became pregnant. CONCLUSION: Postpartum tubal ligations are often not performed despite patient request. Additional measures should be undertaken to ensure that patient requests for postpartum tubal ligation are implemented.

Is cerclage height associated with the incidence of preterm birth in women with an ultrasound-indicated cerclage?

OBJECTIVE: Our aim was to determine whether there was a cerclage height threshold associated with spontaneous preterm birth in patients with an ultrasound-indicated cerclage. STUDY DESIGN: We performed a retrospective cohort study of women with an ultrasound-indicated cerclage. Functional cervical length and the cerclage height (distance from cerclage to the external cervical os) were obtained. Our cohort was grouped into thirds, based on cerclage height percentile. Our primary outcome was spontaneous preterm birth less than 35 weeks. RESULTS: There were 20 women in group 1 (< 18 mm), 25 in group 2 (13-17 mm), and 25 in group 3 (> or = 18 mm). Women with cerclage height 18 mm or greater had a lower incidence of spontaneous preterm birth less than 35 weeks (4%) when compared with those with a cerclage height less than 18 mm (33%) (relative risk, 0.69; 95% confidence interval, 0.55-0.86). CONCLUSION: Cerclage height of 18 mm or greater is associated with a reduction in spontaneous preterm birth for women with an ultrasound-indicated cerclage.

Fetal fibronectin testing for reducing the risk of preterm birth.

BACKGROUND: Fetal fibronectin (FFN) is an extracellular matrix glycoprotein localized at the maternal-fetal interface of the amniotic membranes, between chorion and decidua, where it is concentrated in this area between decidua and trophoblast. In normal conditions, FFN is found at very low levels in cervico-vaginal secretions. Levels greater than or equal to 50 ng/mL at or after 22 weeks have been associated with an increased risk of spontaneous preterm birth. In fact, FFN is one of the best predictors of preterm birth in all populations studied so far, and can help selecting which women are at significant risk for preterm birth. OBJECTIVES: To assess the effectiveness of management based on knowledge of FFN testing results for preventing preterm birth. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (January 2008), MEDLINE (1966 to December 2007) and all references in identified articles. SELECTION CRITERIA: Randomized controlled trials of pregnant women between the gestational ages of 22 and 34 weeks screened with FFN for risk of preterm birth. Studies included are based exclusively on knowledge of FFN results versus no such knowledge, and we have excluded studies including women with only positive or only negative FFN results. DATA COLLECTION AND ANALYSIS: All four authors assessed studies for inclusion and quality and extracted data. MAIN RESULTS: We identified 13 trials, of which five were eligible for inclusion. The five included studies randomized 474 women, of which 235 were randomized to knowledge and 249 to no knowledge of FFN.Preterm birth less than 37 weeks was significantly decreased with management based on knowledge of FFN results (15.6%) versus controls without such knowledge (28.6%; risk ratio 0.54; 95% confidence interval 0.34 to 0.87). All other outcomes for which there were available data (preterm birth at less than 34, 32, or 28 weeks; gestational age at delivery; birthweight less than 2500 grams; perinatal death; maternal hospitalization; tocolysis; steroids for fetal lung maturity; and time to evaluate) were similar in the two groups. No other maternal or neonatal outcome was available for meaningful analysis. AUTHORS' CONCLUSIONS: Although FFN is commonly used in labor and delivery units to help in the management of women with symptoms of preterm labor, currently there is not sufficient evidence to recommend its use. Since this review found an association between knowledge of FFN results and a lower incidence of preterm birth before 37 weeks, further research should be encouraged.

Indomethacin administration at the time of ultrasound-indicated cerclage: is there an association with a reduction in spontaneous preterm birth?

OBJECTIVE: The purpose of this study was to estimate the effect of indomethacin on the prevention of preterm birth (PTB) in women with an ultrasound-indicated cerclage. STUDY DESIGN: We performed a retrospective cohort study from 1995-2006. Asymptomatic women with a cerclage for a short cervical length (CL), which was defined as <25 mm, between 14-23 weeks 6 days of gestation were included. Women who received indomethacin therapy at the time of ultrasound-indicated cerclage for a short CL were compared with those women who did not. Our primary outcome was spontaneous PTB at <35 weeks of gestation. RESULTS: Fifty-one women received indomethacin, and 50 women did not. There were no differences between groups regarding previous PTB, gestational age, or CL at time of cerclage. The rate of spontaneous PTB at <35 weeks of gestation was similar between those who received indomethacin (20/51 [39%]) and those who did not (17/50 [34%]; relative risk, 1.15 [95% CI 0.69-1.93]). In our post hoc power analysis, 190 patients would have been needed to detect a 50% reduction in the rate of PTB. CONCLUSION: Administration of indomethacin around the time of ultrasound-indicated cerclage was not associated with a decrease in spontaneous PTB.

Large foetal sacrococcygeal teratoma complicated by preterm premature rupture of membranes and maternal preeclampsia

A 22-year-old patient, having 29 weeks’ gestation, was referred to Thomas Jefferson University Hospital (Philadelphia, Pennsylvania) after presenting generalized oedema and high blood pressure. The patient was known to carry a foetus with a sacrococcygeal mass and polyhydramnios. A mirror syndrome affecting the mother and cardiac failure in the foetus was initially suspected. Despite some findings indicating poor prognosis for this foetus (i.e. diagnosis in the second trimester, a large rapid growing mass, polyhydramnios, maternal hypertensive disorder and preterm delivery), the neonatal outcome was good and early corrective surgery was performed on the second day of life.

Does knowledge of cervical length and fetal fibronectin affect management of women with threatened preterm labor? A randomized trial.

OBJECTIVE: The purpose of this study was to estimate the effect of sonographic cervical length (CL) and fetal fibronectin (FFN) on length of evaluation and outcomes in women with preterm labor (PTL). STUDY DESIGN: Women with threatened PTL were randomized to either a knowledge group (results of CL and FFN available and used according to study protocol), or a standard group (blinded to CL and FFN). Primary outcome was length of evaluation in triage. RESULTS: One hundred women were randomized. There was no significant difference between groups in length of evaluation, but in women with CL > or = 30 mm, the mean time for evaluation was significantly shorter in the knowledge group (1:58 h +/- 0:50 vs 2:53 h +/- 0:50, P = .004). Incidence of spontaneous preterm birth (SPTB) in the knowledge group was significantly reduced (13.0 vs 36.2%, P = .01). CONCLUSION: The knowledge of CL and FFN was associated with reduction in length of evaluation in women with CL > or = 30 mm and in incidence of SPTB in all women with PTL.

Fetuses with congenital heart disease demonstrate signs of decreased cerebral impedance.

OBJECTIVE: The purpose of this study was to determine whether fetuses with a congenital heart defect demonstrate changes in cerebrovascular impedance. STUDY DESIGN: Fetal echocardiograms from January 2001 to May 2005 were reviewed. Cases had sonographically diagnosed congenital heart defects; control subjects were gestational age-matched fetuses with normal echocardiograms. The pulsatility index in the middle cerebral artery was used to measure impedance to cerebral blood flow. Abnormal middle cerebral artery pulsatility index was defined as less than the 5th percentile. Cases were subgrouped into mixing versus nonmixing lesions. RESULTS: Of 142 total fetuses, there were significantly more abnormal middle cerebral artery pulsatility indices in the cases (5/71) than in the control subjects (0/71; P = .023); all abnormal middle cerebral artery pulsatility indices occurred in the fetuses with admixing cardiac lesions. CONCLUSION: Fetuses with congenital heart defect are significantly more likely to have decreased cerebrovascular impedance. This may represent a marker of cerebral hypoxemia that is due to intracardiac mixing of oxygenated and deoxygenated blood. Theoretically, this hypoxemia may contribute to the cause of abnormal neurologic development in these infants.