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1.
Allergy ; 62(9): 1064-70, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17686109

ABSTRACT

INTRODUCTION: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines provide a stepwise treatment to rhinitis, which classifies the disease according to its duration and severity. OBJECTIVES: The aim of the study was to verify whether these variables influence drug prescriptions for rhinitis and asthma. METHODS: A multi-centre cross-sectional pharmaco-epidemiological survey was carried out on 1,610 allergic rhinitis patients and the relationship between the clinical features of rhinitis and drug therapy for rhinitis and asthma was evaluated. RESULTS: A total of 1,321 adult patients were enrolled. Mild intermittent rhinitis was diagnosed in 7.7%of the patients, moderate/severe intermittent in 17.1%, mild persistent in 11.6%, and moderate/severe persistent in 63.6%. A high level of rhinitis-asthma comorbidity (616/1,321 = 46.6%) was found. The majority of patients [1,060 (80.24%)] were treated. Significant associations between the severity of rhinitis and the presence of therapy (P = 0.008), the use of oral antihistamines (P < 0.001), topical nasal steroids (P = 0.020) and systemic steroids (P = 0.005) were found. A weak association was found between the features of rhinitis and the therapy for asthma, and vice versa the comorbidity with asthma increases the prescription of inhalant (P < 0.001) and oral steroids (P = 0.015) to treat rhinitis. CONCLUSION: The severity of rhinitis influences patient request for rhinitis therapy and the type of medication more than the duration. These features of rhinitis seem to poorly influence asthma therapy. As the ARIA classification is able to reveal a relevant impairment notwithstanding therapy, its role in treated patients merits further study.


Subject(s)
Asthma/classification , Asthma/drug therapy , Rhinitis, Allergic, Perennial/classification , Rhinitis, Allergic, Perennial/drug therapy , Rhinitis, Allergic, Seasonal/classification , Rhinitis, Allergic, Seasonal/drug therapy , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Allergic Agents/therapeutic use , Anti-Asthmatic Agents/therapeutic use , Asthma/diagnosis , Asthma/epidemiology , Female , Humans , Italy/epidemiology , Male , Middle Aged , Practice Guidelines as Topic , Rhinitis, Allergic, Perennial/diagnosis , Rhinitis, Allergic, Perennial/epidemiology , Rhinitis, Allergic, Seasonal/diagnosis , Rhinitis, Allergic, Seasonal/epidemiology , Severity of Illness Index
2.
Clin Exp Allergy ; 37(6): 954-60, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17517110

ABSTRACT

BACKGROUND: Allergic rhinitis and asthma comorbidity is supported by both the similar underlying pathogenesis and immunologic mechanisms. The aim of this study was to verify whether the characteristics of rhinitis classified according to the new Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines correlate with the prevalence of asthma. METHODS: From 1 March to 30 June 2002, a multi-centre cross-sectional study was conducted by 154 allergists chosen from throughout Italy. Duration, severity of rhinitis (according to the ARIA classification) and the type of allergic sensitizations were compared with the prevalence of asthma. RESULTS: One thousand three hundred and twenty-one consecutive rhinitis-allergic patients aged 18 years or older were enrolled for the study. The majority of patients, 1060 (80.24%), were on medication at the time of their specialist visit. Mild intermittent rhinitis was diagnosed in 7.7% of patients, moderate/severe intermittent in 17.1%, mild persistent in 11.6%, and moderate/severe persistent in 63.6%. The prevalence of asthma was 48% in patients with mild intermittent rhinitis, 49.6% in moderate-severe intermittent rhinitis, 36.6% in mild persistent rhinitis and 47.5% in moderate severe persistent patients. No correlation between the ARIA categories of rhinitis and the prevalence of asthma was found. A multivariate analysis, after adjustment for age, sex, type of sensitization, level of severity and duration of rhinitis classified according to the ARIA guidelines, demonstrated that age, over 41 years [risk ratio (RR) 1.260, 95% confidence interval (CI) 1.072-1.482] and especially over 51 years (RR 1.460, 95% CI 1.237-1.723), sensitization to indoor allergens (mite and cat), (RR 1.203, 95% CI 1.060-1.366), and polysensitization (RR 1.178, 95% CI 1.004-1.383) are significant risk factors for asthma. CONCLUSION: In allergic rhinitis (AR) patients referred to a specialist, the features of AR as defined by the ARIA classification are not able to predict the presence of asthma, therefore all such patients should be assessed for asthma.


Subject(s)
Asthma/epidemiology , Rhinitis, Allergic, Seasonal/epidemiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Allergens/immunology , Asthma/classification , Asthma/diagnosis , Asthma/immunology , Comorbidity , Cross-Sectional Studies , Female , Guidelines as Topic , Humans , Italy/epidemiology , Male , Middle Aged , Multivariate Analysis , Predictive Value of Tests , Prevalence , Rhinitis, Allergic, Seasonal/classification , Rhinitis, Allergic, Seasonal/diagnosis , Rhinitis, Allergic, Seasonal/immunology , Risk Factors , Sex Factors , Trauma Severity Indices
3.
Monaldi Arch Chest Dis ; 63(1): 6-12, 2005 Mar.
Article in English | MEDLINE | ID: mdl-16035558

ABSTRACT

BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) underlines that spirometry is the gold standard as the most reproducible, standardised, and objective way of measuring airflow limitation in the diagnosis and assessment of Chronic Obstructive Pulmonary Disease (COPD). However, studies undertaken in different countries have suggested a widespread underuse of spirometry by general practitioners to establish the diagnosis of COPD. Precise estimates of the prevalence of physician-diagnosed COPD in Italy are not currently available. In collaboration with the Italian Academy of General practitioners (SIMG) we have investigated the degree of use of spirometry to establish the diagnosis of COPD in Italy. METHODS: A standardised questionnaire has been self-administered to a sample of 2425 Italian general practitioners (representing 5% of all the Italian doctors involved in general practice). They have been chosen to cover each of the Italian counties. RESULTS: The prevalence of physician-diagnosed COPD was found to be approximately 4%. However, 30% of general practitioners do not use spirometry to establish the diagnosis of COPD. The main reasons given for the failure to use spirometry are (i) that spirometry is not necessary for the diagnosis of COPD or (ii) there are logistical limitations to the access of the patients to lung function laboratories. CONCLUSIONS: This data suggests that contrary to GOLD Guidelines, in Italy, as with other countries, spirometry is not always used in the diagnosis of COPD. There is a clear necessity for further education initiatives targeted to this group of physicians.


Subject(s)
Physicians, Family , Practice Patterns, Physicians'/statistics & numerical data , Pulmonary Disease, Chronic Obstructive/diagnosis , Spirometry/statistics & numerical data , Diagnosis, Differential , Humans , Italy/epidemiology , Prevalence , Pulmonary Disease, Chronic Obstructive/epidemiology , Surveys and Questionnaires
4.
Clin Exp Allergy ; 33(10): 1349-54, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14519139

ABSTRACT

BACKGROUND: The aim of our study was to assess the prevalence of rhinitis, sneezing, runny or blocked nose apart from colds in a pre-school children population and to evaluate the risk factors and relationship with allergic diseases and sensitization. METHODS: Eighteen nursery schools were randomly selected. The International Study of Asthma and Allergies in Childhood (ISAAC) written questionnaire (WQ) was distributed and filled by parents of pre-school children (3-5 years). The allergic sensitization to common aeroallergens and foods was evaluated by skin prick test (SPT). chi2 tests were used to compare proportions between rhinitic and non-rhinitic children. RESULTS: One thousand four hundred and two (92%) valuable questionnaires were returned. Prevalence of rhinitis in the last 12 months was 16.8%. Rhinitic children compared to non-rhinitic children presented a significant increase of diagnosed asthma (20.8% vs. 6.2%, P<0.001), lifetime wheezing (43.2% vs. 21.6%, P<0.001), wheezing in the last 12 months (25.0% vs. 9.4%, P<0.001), atopic dermatitis (22.9% vs. 13.9%, P<0.001) and allergic sensitization (29.9% vs. 13.7%, P<0.001). Sensitization to grass pollen and house dust mites were significant risk factors for rhinitis (P<0.01). A family history of atopy, having pets at home, male gender and greater age were significant risk factors for rhinitis, but not smoking exposure, sharing a bedroom or breastfeeding. CONCLUSIONS: In pre-school children rhinitis has a strong association with wheezing symptoms, asthma and atopic dermatitis. Allergic sensitization is a risk factor for rhinitis and should be evaluated even in pre-school children.


Subject(s)
Hypersensitivity/epidemiology , Rhinitis/epidemiology , Age Factors , Allergens/adverse effects , Asthma/epidemiology , Child, Preschool , Comorbidity , Dermatitis, Atopic/epidemiology , Female , Humans , Italy/epidemiology , Logistic Models , Male , Prevalence , Risk Factors , Seasons , Sex Factors
5.
Pharmacoeconomics ; 18(1): 63-72, 2000 Jul.
Article in English | MEDLINE | ID: mdl-11010605

ABSTRACT

OBJECTIVE: To investigate the psychometric performance and clinical validity of the 36-Item Short Form (SF-36) health survey when completed by asymptomatic HIV-positive Italian patients and to compare their health profile with a representative sample of 2031 Italian citizens (the Italian norm). PATIENTS AND METHODS: This was an observational, multicentre, cross-sectional survey. Microbiologists throughout Italy recruited asymptomatic HIV-positive individuals who were aged at least 18 years and aware of their infection. Investigators collected demographic, social, clinical and treatment data. Patients, classified into 2 clinical categories (A1 and A2) according to explicit pre-defined criteria, completed the SF-36 health survey in the context of a medical visit. RESULTS: Between April and July 1996, 46 microbiologists recruited 214 patients (201 evaluable). No inconsistent responses were observed in 96% of the sample. The usually recommended psychometric standards were satisfied, and the internal consistency reliability indices were always greater than 0.70. Weak to moderate associations were found between SF-36 health survey scores and physicians' estimates of patients' physical performance, while no significant associations were found with CD4+ counts. On average, HIV-positive patients reported lower scores than the Italian norm, and patients in category A2 showed lower scores than patients in A1. These differences were more relevant in scales describing role limitations, general health perception, and psychological well-being. CONCLUSION: Our study showed that the SF-36 health survey maintained its psychometric properties in a sample of Italian asymptomatic HIV-positive patients and produced data that showed its validity and robustness in such a setting.


Subject(s)
HIV Infections/psychology , Quality of Life , Adolescent , Adult , Cross-Sectional Studies , Female , Health Surveys , Humans , Italy , Male , Middle Aged , Psychometrics
6.
Eur Neurol ; 43(2): 102-6, 2000.
Article in English | MEDLINE | ID: mdl-10686468

ABSTRACT

This multicentre, observational, cross-sectional study was conducted to determine migraine prevalence in a sample of population presenting to their GPs. The study covered all the patients who visited the GPs practice, for any reason, on 5 consecutive days of 2 different weeks. A total of 71,588 patients were interviewed by 902 GPs. The prevalence of migraine in this sample was 11.6%.


Subject(s)
Family Practice , Migraine Disorders/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Humans , Italy/epidemiology , Male , Middle Aged , Migraine Disorders/physiopathology , Prevalence
7.
J Infect ; 38(2): 116-20, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10342652

ABSTRACT

OBJECTIVES: To estimate the rate of Herpes zoster and its complications in Italy. METHODS: this is an observational, retrospective study carried out by Dermatologists, Geriatric Doctors and General Practitioners. Details on demography, clinical and therapeutic aspects were reported on record forms. The rate of Herpes zoster was only calculated for patients aged 15 years or more, attending General Practitioners because this was the only group where the number of patients at risk was known. The hypothesis that the rate of complications depends on sex, age and number of affected dermatomes was explored through univariate (Chi-square tests) and multivariate (logistic regression) analysis. RESULTS: the number of cases of Herpes zoster examined by General Practitioners was 4.1 persons aged 15 years or more/1000/year. Usually, only one dermatome was affected, most frequently the thoracic one. Overall the rate of complications was 26.1% The rate of complications is significantly higher (P = 0.001) in patients with two or more affected dermatomes, it is positively correlated to age while difference by sex is not significant (P = 0.297). Practically all patients received treatment for their disease. CONCLUSIONS: this is the first epidemiological study on Herpes zoster that has been conducted in Italy. It indicates that annually there are about 200 000 people aged 15 years and over suffering from Herpes zoster in Italy, with a considerable number of cases of post herpetic neuralgia.


Subject(s)
Herpes Zoster/epidemiology , Herpesvirus 3, Human/pathogenicity , Adult , Age Factors , Aged , Confidence Intervals , Dermatology , Employment , Family Practice , Female , Geriatrics , Herpes Zoster/complications , Humans , Italy/epidemiology , Male , Medical Records , Middle Aged , Multivariate Analysis , Regression Analysis , Retrospective Studies , Sex Factors
8.
Hepatogastroenterology ; 41(1): 54-7, 1994 Feb.
Article in English | MEDLINE | ID: mdl-8175117

ABSTRACT

Twenty-six Italian Centers participated in the present study, the aim of which was to compare, in a double blind manner, the effectiveness of ranitidine 150 mg b.i.d. and ranitidine 300 mg b.i.d. in duodenal ulcer patients, who were considered likely to be slow-responders on the basis of clinical and anamnestic criteria. The results of this study show no statistically significant differences in healing rates between the two groups of patients treated with the different doses of ranitidine. After 4 weeks of treatment, healing rates were 73.3% for ranitidine 150 mg b.i.d. (131 patients) and 76.1% for ranitidine 300 mg b.i.d. (134) patients). After 8 weeks of treatment, cumulative healing rates were 91.5% and 93.9%, respectively. There were no differences in the relief of symptoms. The percentage of ulcers healed after four weeks of treatment with ranitidine 150 mg b.i.d. was lower than generally reported (1, 2), probably reflecting the strict selection criteria. However, at least in this population, the higher dose, with its increased inhibition of gastric acid secretion, failed to offer any significant advantage. Other factors, not dealt with in this study, might help identify the slow-responder and the non-responder, as also those who would benefit from an increased dose.


Subject(s)
Duodenal Ulcer/drug therapy , Ranitidine/therapeutic use , Double-Blind Method , Duodenal Ulcer/pathology , Female , Humans , Male , Middle Aged
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