Subject(s)
Glycerol , Thalassemia/diagnosis , Adolescent , Carrier State , Child , Child, Preschool , Female , Hemolysis/drug effects , Humans , MaleSubject(s)
Intestines/drug effects , Muscle, Smooth/drug effects , Phosphocreatine/pharmacology , Uterus/drug effects , Animals , Female , Mice , Rabbits , RatsABSTRACT
In the dog, rat and chick, phosphocreatine-Na has not caused, from an experimental point of view, significative modifications of the cardiovascular- and respiratory-apparatus, of the reactivity of the cardio-regulator centers, of the baroreceptorial carotid-sinus and glomus reactivity, of the gangliar-, muscarinic-, histaminergic-, dopaminergic-, beta-adrenergic- and serotoninergic- vasomotor reactivity; only the vasomotor reactivity of a constrictive-type induced by epinephrine, nor-epinephrine, occlusion of the two common carotid arteries, hypertension and by BaCl2 is moderately reduced. It is interesting to note that the hypotensive response evoked by adenosine was augmented.
Subject(s)
Cardiovascular System/drug effects , Phosphocreatine/pharmacology , Respiratory System/drug effects , Animals , Blood Pressure/drug effects , Chickens , Dogs , Electrocardiography , Heart Rate/drug effects , Pulmonary Circulation/drug effects , RatsABSTRACT
An experimental assessment was made of the analgesic, anti-inflammatory and platelet anticlumping activity of ketoprophene lysine, and its effect on body temperature and prostaglandin synthesis. The drug's pharmacodynamics was very similar to that of ketoprophene and its gastric tolerance was better. It was also well tolerated by the dog joint surfaces and cardiovascular apparatus when given i.m. or i.v., even at doses higher than those advised for man, or when infiltrated in ketoreceptor areas.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal , Ketoprofen/pharmacology , Lysine/analogs & derivatives , Phenylpropionates/pharmacology , Platelet Aggregation/drug effects , Prostaglandins/biosynthesis , Animals , Body Temperature/drug effects , Dogs , Female , Ketoprofen/analogs & derivatives , Lysine/pharmacology , Male , Malondialdehyde/metabolism , Mice , Rabbits , RatsABSTRACT
Experimental research has shown that pirenzepina possesses interesting inhibiting properties with respect to gastric secretion and the formation of experimentally induced gastric ulcers.
Subject(s)
Benzodiazepinones/pharmacology , Gastric Mucosa/metabolism , Piperazines/pharmacology , Stomach Ulcer/chemically induced , Animals , Atropine/pharmacology , Cardiovascular System/drug effects , Dogs , Dose-Response Relationship, Drug , Female , Gastric Mucosa/drug effects , Kinetics , Male , Mice , Muscle Contraction/drug effects , Pirenzepine , RatsABSTRACT
The A. by a series of experimental works have shown that an association of total bacteria antigens (SPRE) administered in the rabbit vai intramuscular route or by inhalation is able to cause the appearance of serum specific antibodies and to have a significant protective action.
Subject(s)
Antigens, Bacterial/therapeutic use , Immunization/methods , Administration, Intranasal , Animals , Antigens, Bacterial/administration & dosage , Escherichia coli Infections/prevention & control , Female , Injections, Intramuscular , Male , Pseudomonas Infections/prevention & control , Rabbits , Staphylococcal Infections/prevention & control , Streptococcal Infections/prevention & controlSubject(s)
Antiemetics/therapeutic use , Gastric Emptying/drug effects , Metoclopramide/analogs & derivatives , Stomach Ulcer/prevention & control , Vomiting/drug therapy , Animals , Central Nervous System/drug effects , Dogs , Female , Male , Metoclopramide/therapeutic use , Mice , Motor Activity/drug effects , RatsSubject(s)
Fatty Alcohols/pharmacology , Hypolipidemic Agents , Animals , Bile/drug effects , Bile/metabolism , Cholesterol/metabolism , Female , Hyperlipidemias/drug therapy , Male , Mice , Rabbits , RatsABSTRACT
It was shown experimentally that mexilithene possesses anti-arrhythmic activity with slight depression of sino-carotid baroreceptorial and glomo-carotid and gangliar chemoreceptorial activity and catecholamine uptake. Hypotensive and bradycardizing effects were only noted when high per kg doses were used. The drug did not display vascular alpha- and beta-adrenolytic, anti-muscarinic and anti-histaminic activity.
