ABSTRACT
Adrenal myelolipoma (AML) is a rare benign tumor composed of mature adipose and hematopoietic tissue. Most of these patients are asymptomatic and the tumors are non-secreting. We present a case with a large functional adrenal myelolipoma, wherein the patient was hypertensive and biochemistry revealed increase in 24 hours urinary Vanillylmandelic Acid (VMA), a metabolite of catecholamine. The mass was removed surgically and diagnosed as adrenal myelolipoma on histopathological examination. Both his blood pressure and urinary VMA returned to normal following surgery, which suggested that the mass was functioning and was secreting catecholamine. To the best of our knowledge, a catecholamine secreting adrenal myelolipoma has been reported in the literature only once previously. The association of hypertension and adrenal myelolipoma may not be entirely coincidental, as it may be associated with secreting catecholamine, as seen in our case. We also review the literature on functioning adrenal myelolipoma.
Subject(s)
Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/pathology , Catecholamines/metabolism , Myelolipoma/diagnosis , Myelolipoma/pathology , Adrenal Gland Neoplasms/surgery , Histocytochemistry , Humans , Hypertension/etiology , Male , Microscopy , Middle Aged , Myelolipoma/surgery , Vanilmandelic Acid/urineABSTRACT
Xeroderma pigmentosum is an uncommon skin disorder associated with increased incidence of skin tumours and, less often, internal malignancies. Wilms' tumour is a common paediatric tumour, observed rarely in adults. Here we report the rare association of Xeroderma pigmentosum with adult Wilms' tumour in two Libyan females. To the best of our knowledge, this association has not been reported so far in the literature.
Subject(s)
Kidney Neoplasms/complications , Skin Diseases/complications , Wilms Tumor/complications , Xeroderma Pigmentosum/complications , Adolescent , Family Health , Female , Humans , Pedigree , Skin Diseases/genetics , Xeroderma Pigmentosum/geneticsABSTRACT
The ovary is a common site of both primary and secondary tumours. It may be the seat of simultaneous presence of more than one tumour. Often a combination of a malignant tumour is seen within the ovary harbouring a benign tumour. Simultaneous presence of two malignant tumours is rare. Here we describe a 43 year old woman presenting with a simultaneous metastatic adenocarcinoma (primary in colon) along with a papillary serous cystadenocarcinoma of the ovary.
Subject(s)
Adenocarcinoma/secondary , Colonic Neoplasms/pathology , Cystadenocarcinoma, Serous/pathology , Neoplasms, Multiple Primary/pathology , Ovarian Neoplasms/secondary , Adenocarcinoma/pathology , Adenocarcinoma/surgery , Adult , Colonic Neoplasms/surgery , Cystadenocarcinoma, Serous/surgery , Female , Humans , Neoplasms, Multiple Primary/surgery , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgeryABSTRACT
From the time the first case of bronchial cleft carcinoma was reported over a century ago, very few cases have been reported which prove to be a cancer of primary branchial origin, while many metastatic cystic squamous cell carcinomas in the neck have been wrongly categorized as branchial carcinoma. Here, we describe a case of primary branchiogenic carcinoma in a 53 year old Libyan female showing a transformation of a benign epithelium into a malignant type. We further report that this transformation is perhaps brought about by an irregular radiotherapy to the head and neck region.
Subject(s)
Branchioma/etiology , Head and Neck Neoplasms/etiology , Neoplasms, Radiation-Induced , Branchioma/pathology , Female , Head and Neck Neoplasms/pathology , Humans , Middle Aged , Neoplasms, Radiation-Induced/pathologyABSTRACT
In this study the frequency of primary bone tumours in the eastern part of Libya during a period of 10 years (1981 to 1990) is analysed. During this period 165 histologically proved primary bone tumours were seen. Out of these 165 tumours 40 were malignant and 125 were benign. Males were more frequently affected by the primary bone tumours. The second decade was the most common age of incidence for both benign and malignant tumours. The femur was the most common site. Comparison with similar studies from selected parts of the world indicated that the frequency of primary malignant bone tumours in Eastern Libya appears to be low.
