Salud percibida y rendimiento académico en adolescentes de escuelas públicas de la ciudad de Córdoba / Perceived health and academic performance among adolescents from public schools in the city of Córdoba

Introducción. El desempeno en la escuela podría estar vinculado a la salud en la adolescencia, y los logros educativos en esta edad pueden influir en la vida futura. El objetivo fue estudiar la asociación entre el rendimiento académico y la salud percibida en adolescentes, teniendo en cuenta las características sociodemográficas de sus familias. Población y métodos. Estudio piloto transversal en una muestra de adolescentes asistentes al ciclo básico de tres escuelas secundarias públicas de la ciudad de Córdoba, Argentina. El rendimiento académico se computó como el promedio de las calificaciones en todas las asignaturas y se consideró suficiente cuando fue igual a 6 puntos o mayor. La salud percibida se valoró con el cuestionario KIDSCREEN-52, que produce puntuaciones en diez dimensiones. Además, se recogió la edad, el sexo, el nivel de escolaridad materna, el nivel socioeconómico y la composición de la familia. Se realizaron análisis univariados, bivariados y modelos multivariados de regresión logística. Resultados. Participaron 554 adolescentes, 52% de los cuales eran mujeres. El rendimiento académico insuficiente (27,6%) fue más frecuente en los adolescentes que manifestaron peor relación con los padres (OR 2,68; IC 95%: 1,225,85) y mejor relación con amigos (OR 0,46; IC 95%: 0,26-0,82). Hubo diferencias al estratificar por nivel socioeconómico: en el nivel alto, el rendimiento insuficiente fue más frecuente en adolescentes conpercepción de menor autonomía y, en el nivel medio-bajo, en adolescentes con peor percepción del entorno escolar. Conclusión. El rendimiento académico se asoció a dimensiones psicosociales de la salud, como sus relaciones familiares, con amigos, autonomía y entorno escolar.

Introduction. During adolescence, school performance may be related to health, and academic achievements at this age can have an impact on the future. Our objective was to assess the relationship between academic performance and perceived health among adolescents, considering sociodemographic characteristics of their families. Population and Methods. Cross-sectional pilot study conducted in a sample of adolescents attending common basic courses of three public secondary schools in the city of Córdoba (Argentina). Academic performance was calculated as the average grade in all subjects; performance was considered satisfactory if equal to or higher than 6. Perceived health was assessed using the KIDSCREEN-52 questionnaire, which scores ten dimensions. In addition, age, sex, maternal education level, socioeconomic level and household composition were also recorded. Univariate and bivariate analyses and multivariate logistic regression models were conducted. Results. Five hundred fifty-four adolescents participated, 52% of them were girls. Unsatisfactory academic performance (27.6%) was more common among adolescents who evidenced a worse relationship with parents (OR: 2.68, 95% CI: 1.22-5.85) and a better relationship with peers (OR: 0.46, 95% CI: 0.26-0.82). Stratification by socioeconomic level showed differences: among those with a high socioeconomic level, an unsatisfactory performance was more common among adolescents who perceived themselves as having a low autonomy, while it was more common among those who perceived a worse school environment in the middle-low socioeconomic level. Conclusion. Academic performance was associated with psychosocial dimensions of health, such as relationship with family members, peers, autonomy and school environment.

[Perceived health and academic performance among adolescents from public schools in the city of Córdoba]. / Salud percibida y rendimiento académico en adolescentes de escuelas públicas de la ciudad de Córdoba.

INTRODUCTION: During adolescence, school performance may be related to health, and academic achievements at this age can have an impact on the future. Our objective was to assess the relationship between academic performance and perceived health among adolescents, considering sociodemographic characteristics of their families. POPULATION AND METHODS: Cross-sectional pilot study conducted in a sample of adolescents attending common basic courses of three public secondary schools in the city of Córdoba (Argentina). Academic performance was calculated as the average grade in all subjects; performance was considered satisfactory if equal to or higher than 6. Perceived health was assessed using the KIDSCREEN-52 questionnaire, which scores ten dimensions. In addition, age, sex, maternal education level, socioeconomic level and household composition were also recorded. Univariate and bivariate analyses and multivariate logistic regression models were conducted. RESULTS: Five hundred fifty-four adolescents participated, 52% of them were girls. Unsatisfactory academic performance (27.6%) was more common among adolescents who evidenced a worse relationship with parents (OR: 2.68, 95% CI: 1.22-5.85) and a better relationship with peers (OR: 0.46, 95% CI: 0.26-0.82). Stratification by socioeconomic level showed differences: among those with a high socioeconomic level, an unsatisfactory performance was more common among adolescents who perceived themselves as having a low autonomy, while it was more common among those who perceived a worse school environment in the middle-low socioeconomic level. CONCLUSION: Academic performance was associated with psychosocial dimensions of health, such as relationship with family members, peers, autonomy and school environment.

Introducción. El desempeño en la escuela podría estar vinculado a la salud en la adolescencia, y los logros educativos en esta edad pueden influir en la vida futura. El objetivo fue estudiar la asociación entre el rendimiento académico y la salud percibida en adolescentes, teniendo en cuenta las características sociodemográficas de sus familias. Población y métodos. Estudio piloto transversal en una muestra de adolescentes asistentes al ciclo básico de tres escuelas secundarias públicas de la ciudad de Córdoba, Argentina. El rendimiento académico se computó como el promedio de las calificaciones en todas las asignaturas y se consideró suficiente cuando fue igual a 6 puntos o mayor. La salud percibida se valoró con el cuestionario KIDSCREEN-52, que produce puntuaciones en diez dimensiones. Además, se recogió la edad, el sexo, el nivel de escolaridad materna, el nivel socioeconómico y la composición de la familia. Se realizaron análisis univariados, bivariados y modelos multivariados de regresión logística. Resultados. Participaron 554 adolescentes, 52% de los cuales eran mujeres. El rendimiento académico insuficiente (27,6%) fue más frecuente en los adolescentes que manifestaron peor relación con los padres (OR 2,68; IC 95%: 1,22- 5,85) y mejor relación con amigos (OR 0,46; IC 95%: 0,26-0,82). Hubo diferencias al estratificar por nivel socioeconómico: en el nivel alto, el rendimiento insuficiente fue más frecuente en adolescentes con percepción de menor autonomía y, en el nivel medio-bajo, en adolescentes con peor percepción del entorno escolar. Conclusión. El rendimiento académico se asoció a dimensiones psicosociales de la salud, como sus relaciones familiares, con amigos, autonomía y entorno escolar.

Enantioselective synthesis of all-carbon quaternary stereogenic centers via copper-catalyzed asymmetric allylic alkylation of (Z)-allyl bromides with organolithium reagents.

A copper/phosphoramidite catalyzed asymmetric allylic alkylation of Z trisubstituted allyl bromides with organolithium reagents is reported. The reaction affords all-carbon quaternary stereogenic centers in high yields and very good regio- and enantioselectivity. This systematic study illustrates the crucial role of the olefin geometry of the allyl substrate on the outcome of the reaction and provides a viable alternative to access these important structural motifs.

Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors.

N-(2-Oxo-3-oxetanyl)carbamic acid esters have recently been reported to be noncompetitive inhibitors of the N-acylethanolamine acid amidase (NAAA) potentially useful for the treatment of pain and inflammation. In the present study, we further explored the structure-activity relationships of the carbamic acid ester side chain of 2-methyl-4-oxo-3-oxetanylcarbamic acid ester derivatives. Additional favorable features in the design of potent NAAA inhibitors have been found together with the identification of a single digit nanomolar inhibitor. In addition, we devised a 3D QSAR using the atomic property field method. The model turned out to be able to account for the structural variability and was prospectively validated by designing, synthesizing, and testing novel inhibitors. The fairly good agreement between predictions and experimental potency values points to this 3D QSAR model as the first example of quantitative structure-activity relationships in the field of NAAA inhibitors.

Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors.

N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that preferentially hydrolyzes saturated or monounsaturated fatty acid ethanolamides (FAEs), such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), which are endogenous agonists of nuclear peroxisome proliferator-activated receptor-α (PPAR-α). Compounds that feature an α-amino-ß-lactone ring have been identified as potent and selective NAAA inhibitors and have been shown to exert marked anti-inflammatory effects that are mediated through FAE-dependent activation of PPAR-α. We synthesized and tested a series of racemic, diastereomerically pure ß-substituted α-amino-ß-lactones, as either carbamate or amide derivatives, investigating the structure-activity and structure-stability relationships (SAR and SSR) following changes in ß-substituent size, relative stereochemistry at the α- and ß-positions, and α-amino functionality. Substituted carbamate derivatives emerged as more active and stable than amide analogues, with the cis configuration being generally preferred for stability. Increased steric bulk at the ß-position negatively affected NAAA inhibitory potency, while improving both chemical and plasma stability.

Validez del peso y la talla declarados en adolescentes escolarizados de la ciudad de Córdoba / Validity of self-reported weight and height by high school students in the city of Cordoba city

Objetivo: Examinar la validez del peso y la estaturadeclarados respecto de su medición directa, para eldiagnóstico de sobrepeso y obesidad en adolescentesescolarizados de la ciudad de Córdoba.Métodos: Se realizó un estudio piloto transversal con552 adolescentes de 1° a 3° año de tres escuelas secundarias.El peso y la talla se recolectaron mediante un cuestionarioautoadministrado y fueron medidos directamente porpersonal entrenado. Se calcularon diferencias de promediode peso, talla e índice de masa corporal (IMC=kg/cm2) ysensibilidad-especificidad y coeficiente de concordancia (k)para las categorías de diagnóstico.Resultados: El peso declarado promedio fue subestimadorespecto del medido; no así la talla. El IMC declarado resultósubestimado en -0,85 kg/cm2 en mujeres y -0,26 kg/cm2 envarones. La sensibilidad-especificidad fue 61%-89% paradetectar sobrepeso y 80%-98% para diagnosticar obesidad.Conclusión: El peso y la talla autoinformados produjeronsubestimación de la prevalencia de sobrepeso pero no deobesidad.(AU)

Objective: To examine the validity of self-reported weight and height versus their directmeasurement for the diagnosis of overweight and obesity in adolescent students in thecity of Cordoba.Methods: A cross-sectional pilot study was carried out with 552 adolescents attending1st to 3rd year at three high schools. Weight and height were collected through a selfadministeredquestionnaire and were measured directly by trained staff. We calculatedaverage differences for weight, height and body mass index (BMI = kg/cm2), and sensitivityspecificityand concordance coefficient (k) were analyzed for overweight and obesitydiagnosis.Results: Average self-reported weight was underestimated compared to measuredweight, but not self-reported height. Declared BMI was underestimated -0.85 kg/cm2in women and -0.26 kg/cm2 in men. The sensitivity-specificity was 61%-89% to detectoverweight, and 80%-98% to diagnose obesity.Conclusion: The self-reported weight and height underestimated the prevalence ofoverweight but not of obesity.(AU)

Validez del peso y la talla declarados en adolescentes escolarizados de la ciudad de Córdoba / Validity of self-reported weight and height by high school students in the city of Cordoba city

Objetivo: Examinar la validez del peso y la estaturadeclarados respecto de su medición directa, para eldiagnóstico de sobrepeso y obesidad en adolescentesescolarizados de la ciudad de Córdoba.Métodos: Se realizó un estudio piloto transversal con552 adolescentes de 1° a 3° año de tres escuelas secundarias.El peso y la talla se recolectaron mediante un cuestionarioautoadministrado y fueron medidos directamente porpersonal entrenado. Se calcularon diferencias de promediode peso, talla e índice de masa corporal (IMC=kg/cm2) ysensibilidad-especificidad y coeficiente de concordancia (k)para las categorías de diagnóstico.Resultados: El peso declarado promedio fue subestimadorespecto del medido; no así la talla. El IMC declarado resultósubestimado en -0,85 kg/cm2 en mujeres y -0,26 kg/cm2 envarones. La sensibilidad-especificidad fue 61%-89% paradetectar sobrepeso y 80%-98% para diagnosticar obesidad.Conclusión: El peso y la talla autoinformados produjeronsubestimación de la prevalencia de sobrepeso pero no deobesidad.

Objective: To examine the validity of self-reported weight and height versus their directmeasurement for the diagnosis of overweight and obesity in adolescent students in thecity of Cordoba.Methods: A cross-sectional pilot study was carried out with 552 adolescents attending1st to 3rd year at three high schools. Weight and height were collected through a selfadministeredquestionnaire and were measured directly by trained staff. We calculatedaverage differences for weight, height and body mass index (BMI = kg/cm2), and sensitivityspecificityand concordance coefficient (k) were analyzed for overweight and obesitydiagnosis.Results: Average self-reported weight was underestimated compared to measuredweight, but not self-reported height. Declared BMI was underestimated -0.85 kg/cm2in women and -0.26 kg/cm2 in men. The sensitivity-specificity was 61%-89% to detectoverweight, and 80%-98% to diagnose obesity.Conclusion: The self-reported weight and height underestimated the prevalence ofoverweight but not of obesity.

Sobrepeso y obesidad en adolescentes escolarizados de la ciudad de Córdoba, Argentina, en 2010 / Overweight and obesity in adolescents receiving school education in the city of Córdoba, Argentina in 2010

INTRODUCCION: La obesidad infanto-juvenil constituye un problema de salud pública. Es necesario lograr una mirada integral de esta situación para prevenir sus consecuencias.OBJETIVO: Analizar la situación de adolescentes con sobrepeso y obesidad en comparación con aquellos sin exceso de peso, considerando la percepción de la imagen corporal, el consumo de alimentos y el tiempo libre. Identificar las motivaciones, las barreras y los sentimientos de autoestima y autoeficacia que pueden explicar hábitos asociados al exceso de peso.METODOS: Se realizó un estudio transversal cuanti-cualitativo en adolescentes de escuelas secundarias de Córdoba. Se aplicó un cuestionario autoadministrado y se tomaron medidas antropométricas. El índice de masa corporal fue clasificado según el criterio de la International Obesity Task Force. Se organizaron grupos focales. El estudio incluyó análisis bivariado en los datos cuantitativos y análisis de contenido de los cualitativos.RESULTADOS: La prevalencia fue de 9,1% en obesidad y de 24,5% en sobrepeso (n = 552) y resultó mayor en varones (p < 0,001). No se comprobó asociación con consumo de alimentos ni con actividades sedentarias. El 83% de los obesos no percibió su imagen corporal como la real (p < 0,001). Los adolescentes manifestaron motivaciones y explicaron barreras para realizar actividad física y una alimentación saludable.CONCLUSIONES: La alimentación rica en calorías y el sedentarismo son frecuentes. Las actividades preventivas deben tener en cuenta las preferencias, las barreras y los límites a la autoeficacia que manifiestan los adolescentes.

INTRODUCTION: Obesity is a public health problem in childhood and adolescence. Its prevention requires a comprehensive view of the current situation.OBJECTIVE: The present study intentd so analyze the situation of adolescents with overweight and obesity compared with those without weight excess, considering perception of body image, food consumption and leisure time. It also intends to identify the motivations, barriers and feelings of self-efficacy with tend to overweight of adolescents.METHODS: A quantitative and qualitative cross-sectional study was conducted among adolescents attending public secondary schools in Córdoba. In included a self-administered questionnaire and anthropometric measurements. The body mass index was classified according to the International Obesity Task Force criteria. There were also focus groups as well as a bivariate analysis of quantitative data and content analysis of qualitative data.RESULTS: The prevalence was 9.1% for obesity and 24.5% for overweight (n = 552). It was higher in males (p < 0.001), and was associated neither with food consumption nor with sedentary activities. 83% of obese people did not perceibe their body image as real (p < 0.001). Adolescents also showed motivation and several barriers to physical activity and healthy eating.CONCLUSIONS: Hypercaloric diet and sedentary habits are frequent. Preventive activities must take into account the preferences, barriers and limits to self-efficacy shown by adolescents.

Sobrepeso y obesidad en adolescentes escolarizados de la ciudad de Córdoba, Argentina, en 2010 / Overweight and obesity in adolescents receiving school education in the city of Córdoba, Argentina in 2010

INTRODUCCION: La obesidad infanto-juvenil constituye un problema de salud pública. Es necesario lograr una mirada integral de esta situación para prevenir sus consecuencias.OBJETIVO: Analizar la situación de adolescentes con sobrepeso y obesidad en comparación con aquellos sin exceso de peso, considerando la percepción de la imagen corporal, el consumo de alimentos y el tiempo libre. Identificar las motivaciones, las barreras y los sentimientos de autoestima y autoeficacia que pueden explicar hábitos asociados al exceso de peso.METODOS: Se realizó un estudio transversal cuanti-cualitativo en adolescentes de escuelas secundarias de Córdoba. Se aplicó un cuestionario autoadministrado y se tomaron medidas antropométricas. El índice de masa corporal fue clasificado según el criterio de la International Obesity Task Force. Se organizaron grupos focales. El estudio incluyó análisis bivariado en los datos cuantitativos y análisis de contenido de los cualitativos.RESULTADOS: La prevalencia fue de 9,1% en obesidad y de 24,5% en sobrepeso (n = 552) y resultó mayor en varones (p < 0,001). No se comprobó asociación con consumo de alimentos ni con actividades sedentarias. El 83% de los obesos no percibió su imagen corporal como la real (p < 0,001). Los adolescentes manifestaron motivaciones y explicaron barreras para realizar actividad física y una alimentación saludable.CONCLUSIONES: La alimentación rica en calorías y el sedentarismo son frecuentes. Las actividades preventivas deben tener en cuenta las preferencias, las barreras y los límites a la autoeficacia que manifiestan los adolescentes.

INTRODUCTION: Obesity is a public health problem in childhood and adolescence. Its prevention requires a comprehensive view of the current situation.OBJECTIVE: The present study intentd so analyze the situation of adolescents with overweight and obesity compared with those without weight excess, considering perception of body image, food consumption and leisure time. It also intends to identify the motivations, barriers and feelings of self-efficacy with tend to overweight of adolescents.METHODS: A quantitative and qualitative cross-sectional study was conducted among adolescents attending public secondary schools in Córdoba. In included a self-administered questionnaire and anthropometric measurements. The body mass index was classified according to the International Obesity Task Force criteria. There were also focus groups as well as a bivariate analysis of quantitative data and content analysis of qualitative data.RESULTS: The prevalence was 9.1% for obesity and 24.5% for overweight (n = 552). It was higher in males (p < 0.001), and was associated neither with food consumption nor with sedentary activities. 83% of obese people did not perceibe their body image as real (p < 0.001). Adolescents also showed motivation and several barriers to physical activity and healthy eating.CONCLUSIONS: Hypercaloric diet and sedentary habits are frequent. Preventive activities must take into account the preferences, barriers and limits to self-efficacy shown by adolescents.

Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach.

We report on the use of a diversity oriented synthesis (DOS) approach that resulted in the generation of a set of libraries of compounds presenting novel structural cores. These chemical cores have been employed to design potential antagonists of the antiapoptotic protein Bcl-x(L) through reiterated steps of molecular docking calculations followed by experimental verification of binding. Our data suggest that the DOS approach is suitable to generate novel scaffolds, which can be employed to target protein-protein interactions.