Subject(s)
Abdominal Pain/etiology , Superior Mesenteric Artery Syndrome/complications , Adolescent , Humans , Male , RecurrenceABSTRACT
Celiac disease (CD) is a known cause of short stature and sometimes, this is its only symptom. The aim of this work was to determine the incidence of CD in children with short stature. We studied 178 infants with short stature and with no gastrointestinal symptoms. Serum IgA antigliadin antibodies were determined in all of them. We found a pathological titer in ten of these patients. Peroral intestinal biopsy was performed on these children, with nine showing no alterations and only one having subtotal villus atrophy that was compatible with CD. Therefore, the incidence of CD in this population is about 0.56%, which is much lower than the incidence shown by other authors.
Subject(s)
Body Height , Celiac Disease/physiopathology , Gliadin/immunology , Adolescent , Antibodies/immunology , Celiac Disease/immunology , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
Celiac disease (CD) is a permanent gluten-sensitive enteropathy appearing in individuals genetcally predisposed. Its incidence varies according to the authors, but is situated about 1/1.500 alive newborn infants (ANI). Recently, a decreased in the incidence of the disease as well as a delay in the onset of symptoms have been reported in several countries. The incidence of the disease in Spain is unknown so we have studied it in our population. In the period 1976-1987, 117 patients were suspected to have CD in the different centers performing intestinal biopsies in Vizcaya. Diagnosis was confirmed in 87 cases, thus implying an incidence of 1/2.151 ANI. Age onset has been stable along the years, and most cases continue to be diagnosed during the first 2 years of life.
Subject(s)
Celiac Disease/epidemiology , Biopsy , Celiac Disease/genetics , Celiac Disease/pathology , Child , Child, Preschool , Humans , Infant , Infant, Newborn , Intestinal Mucosa/pathology , Spain/epidemiologyABSTRACT
Celiac disease (CD) is one of the most malabsorption syndromes in Pediatrics, its diagnosis being based on peroral intestinal biopsy. During the period 1974-1988 we have studied 178 patients with the suspected diagnosis of CD: diagnosis was confirmed in 117 whereas 22 are still under study. Mean age of the patients was 22.5 +/- 22.7 months, diagnosis being made during the first year of life in 32.6% of cases. Most cases had a classic clinical onset, although over the last year symptoms seen to be less apparent. Several patients presented with atypical forms. Also, associated diseases are observed in several cases. CD is often presented nowadays with few or atypical symptoms of difficult diagnosis and in this context the use of immunologic markers may be specially helpful.
Subject(s)
Celiac Disease/diagnosis , Celiac Disease/genetics , Celiac Disease/immunology , Child, Preschool , Diagnosis, Differential , Humans , Infant , Intestinal Absorption , Malabsorption Syndromes/diagnosis , PhenotypeABSTRACT
IgG serum levels were measured in 25 patients with cystic fibrosis aged 1 to 19 years and in 4 additional patients deceased over the last 4 years. Levels were correlated with a number of parameters. Twelve patients (group A) had raised IgG levels, and 17 (group B) normal or low levels. Age between groups did not differ. Patients in group A had lower Shwachman score (p less than 0.001), worse Chrispin and Norman radiologic score (p less than 0.05), lower weight (p less than 0.001) and height (p less than 0.05) and lower FVC (p less than 0.05), and FEV1 (p less than 0.01). Raised levels were associated with increased number of serum precipitins against Pseudomonas aeruginosa but not against Staphylococcus aureus. Raised IgG levels might be secondary to heavier bronchial infection, but there is growing evidence that immunologic response in cystic fibrosis may worsen the course of the disease.
Subject(s)
Cystic Fibrosis/blood , Immunoglobulin G/analysis , Adolescent , Body Weight , Child , Child, Preschool , Cystic Fibrosis/complications , Cystic Fibrosis/immunology , Cystic Fibrosis/physiopathology , Forced Expiratory Volume , Humans , Infant , Prognosis , Prospective Studies , Pseudomonas Infections/etiology , Staphylococcal Infections/etiology , Vital CapacitySubject(s)
Breast Feeding , Infant Food , Infant Nutritional Physiological Phenomena , Age Factors , Humans , InfantABSTRACT
Eight cases of acute gastroenteritis, two caused by enteropathogenic "E. coli", with secondary cow's milk protein intolerance were studied. Diagnosis was established clinically and by means of intestinal biopsy, before and after a milk challenge. The role of acute gastroenteritis as a trigger of cow's milk protein intolerance and other factors contributing to the appearance of that complication are discussed. The mechanisms leading to intractable diarrhoea in a situation of prolonged gastroenteritis are also commented.
Subject(s)
Gastroenteritis/complications , Lactose Intolerance/etiology , Milk Proteins/metabolism , Diagnosis, Differential , Escherichia coli/isolation & purification , Escherichia coli Infections/complications , Female , Gastroenteritis/microbiology , Humans , Infant , Infant, Newborn , Infant, Newborn, Diseases/microbiology , MaleABSTRACT
Authors present a prospective study upon 193 cases of acute gastroenteritis in infants 1 to 24 months of age, giving special attention to clinical evolution of the disease without any use of therapy of either antibiotics or other antidiarrheal agents. Data on epidemiology and etiology of this series are similar to those previously reported by other authors. Mean duration of diarrhea was 2,5 days, whereas mean hospital stay was 7,5 days. The number of cases of prolonged diarrhea was 13, from which six were cases of lactose intolerance, six were cases of cow's milk protein intolerance and one was a case of intractable diarrhea. The little use fulness of antibiotics in the treatment of acute diarrhea is commented and also a discussion is made of the different factors involved in the onset of the complications above mentioned.
