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Vet J ; 190(2): e43-e47, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21596598

ABSTRACT

Molecular analysis, serology and immunophenotyping for T lymphocytes and their subsets, B lymphocytes and monocytes were performed on dogs naturally infected with Leishmania infantum. Animals were categorised as asymptomatic dogs I (AD-I), with negative serology and positive molecular results, and asymptomatic dogs II (AD-II), with positive serology and positive molecular results, and these were compared to symptomatic dogs (SD) and control dogs (CD). AD-I exhibited immunophenotypic features similar to those of CD, including isotype profiles and concentrations of monocytes. Similar biomarkers were found in AD-II and SD, such as, higher levels of immunoglobulins IgG, IgG2, IgM and IgA and higher concentrations of eosinophils. High frequencies of T lymphocytes and CD4(+) T cells were observed in both AD-I and AD-II compared to SD, whereas CD8(+) T cells were higher only in AD-II compared with SD. Analysis of B lymphocytes revealed an increased frequency of this cell type only in AD-II animals compared with SD. Asymptomatic dogs appear to have a dichotomous infection spectrum that can influence the humoral and cellular immunological status during canine visceral leishmaniasis.


Subject(s)
Asymptomatic Infections , Dog Diseases/immunology , Immunity, Cellular , Immunity, Humoral , Leishmania infantum/immunology , Leishmaniasis, Visceral/veterinary , Animals , Antibodies, Protozoan/blood , B-Lymphocytes/metabolism , Biomarkers/blood , CD4-CD8 Ratio/veterinary , Case-Control Studies , Disease Resistance , Dog Diseases/parasitology , Dogs , Enzyme-Linked Immunosorbent Assay/veterinary , Eosinophils/metabolism , Flow Cytometry/veterinary , Immunoglobulins/blood , Leishmaniasis, Visceral/immunology , Monocytes/metabolism , T-Lymphocyte Subsets/metabolism , T-Lymphocytes/metabolism
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